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Drug Metabolism & Disposition

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Table of Contents

April 01, 2001; Volume 29,Issue 4

Articles

  • You have access
    Cellular Distribution and Handling of Liver-Targeting Preparations in Human Livers Studied by a Liver Lobe Perfusion
    Barbro N. Melgert, Peter Olinga, Betty Weert, Maarten J. H. Slooff, Dirk K. F. Meijer, Klaas Poelstra and Geny M. M. Groothuis
    Drug Metabolism and Disposition April 2001, 29 (4) 361-367;
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    Substrate Inhibition Kinetics for Cytochrome P450-Catalyzed Reactions
    Yuh Lin, Ping Lu, Cuyue Tang, Qin Mei, Grit Sandig, A. David Rodrigues, Thomas H. Rushmore and Magang Shou
    Drug Metabolism and Disposition April 2001, 29 (4) 368-374;
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    S-Naproxen-β-1-O-acyl Glucuronide Degradation Kinetic Studies by Stopped-Flow High-Performance Liquid Chromatography-1H NMR and High-Performance Liquid Chromatography-UV
    Rasmus W. Mortensen, Olivia Corcoran, Claus Cornett, Ulla G. Sidelmann, John C. Lindon, Jeremy K. Nicholson and Steen Honoré Hansen
    Drug Metabolism and Disposition April 2001, 29 (4) 375-380;
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    Metabolism of Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) by Human Liver Microsomes: Characterization of Metabolic Pathways and of Cytochrome P450 Isoforms Involved
    Min-Sun Baek, Ji-Yeon Kim, Seung-Woon Myung, Yong Hyeon Yim, Jin-Hyun Jeong and Dong-Hyun Kim
    Drug Metabolism and Disposition April 2001, 29 (4) 381-388;
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    Mechanism-Based Inhibition of Human Cytochrome P450 1A1 by Rhapontigenin
    Young Jin Chun, Shi Yong Ryu, Tae Cheon Jeong and Mie Young Kim
    Drug Metabolism and Disposition April 2001, 29 (4) 389-393;
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    Carrier-Mediated Hepatobiliary Transport of a Novel Antifolate,N-[4-[(2,4-Diamminopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-Homoglutamic Acid, in Rats
    Yong-Hae Han, Yukio Kato, Yuka Watanabe, Kimio Terao, Yoshinori Asoh and Yuichi Sugiyama
    Drug Metabolism and Disposition April 2001, 29 (4) 394-400;
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    Methemoglobin Oxidation of N-Acetylbenzidine to Form a Sulfinamide
    Terry V. Zenser, Vijaya M. Lakshmi, Fong Fu Hsu and Bernard B. Davis
    Drug Metabolism and Disposition April 2001, 29 (4) 401-406;
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    In Vitro Glucuronidation of the Cyclin-Dependent Kinase Inhibitor Flavopiridol by Rat and Human Liver Microsomes: Involvement of UDP-Glucuronosyltransferases 1A1 and 1A9
    Birgit Hagenauer, Alexandra Salamon, Therese Thalhammer, Olaf Kunert, Ernst Haslinger, Paul Klingler, Adrian M. Senderowicz, Edward A. Sausville and Walter Jäger
    Drug Metabolism and Disposition April 2001, 29 (4) 407-414;
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    Pharmacokinetics and Metabolism of Nateglinide in Humans
    Margaret L. Weaver, Barbara A. Orwig, Lolita C. Rodriguez, Elizabeth D. Graham, Jefferson A. Chin, Michael J. Shapiro, James F. McLeod and James B. Mangold
    Drug Metabolism and Disposition April 2001, 29 (4) 415-421;
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    A Preclinical Pharmacokinetic Study of the Bioreductive Drug AQ4N
    P. M. Loadman, D. J. Swaine, M. C. Bibby, K. J. Welham and L. H. Patterson
    Drug Metabolism and Disposition April 2001, 29 (4) 422-426;
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    Decreases in Phenytoin Hydroxylation Activities Catalyzed by Liver Microsomal Cytochrome P450 Enzymes in Phenytoin-Treated Rats
    Hiroshi Yamazaki, Tomoko Komatsu, Kei Takemoto, Mayuko Saeki, Yoshinori Minami, Yasuro Kawaguchi, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 2001, 29 (4) 427-434;
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    The Disposition of Gemifloxacin, a New Fluoroquinolone Antibiotic, in Rats and Dogs
    J. V. Ramji, N. E. Austin, G. W. Boyle, M. H. Chalker, G. Duncan, A. J. Fairless, F. J. Hollis, D. F. McDonnell, T. J. Musick and P. C. Shardlow
    Drug Metabolism and Disposition April 2001, 29 (4) 435-442;
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    Prediction of Midazolam—cyp3a Inhibitors Interaction in the Human Liver from in Vivo/in Vitro Absorption, Distribution, and Metabolism Data
    Katsuhiro Yamano, Koujirou Yamamoto, Masataka Katashima, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Hisakazu Ohtani, Yasufumi Sawada and Tatsuji Iga
    Drug Metabolism and Disposition April 2001, 29 (4) 443-452;
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    Uptake of Teicoplanin by Isolated Rat Hepatocytes: Comparison with in Vivo Hepatic Distribution
    Raquel F. Reinoso, Brian A. Telfer, Beverley S. Brennan and Malcolm Rowland
    Drug Metabolism and Disposition April 2001, 29 (4) 453-459;
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    Flunitrazepam Metabolism by Cytochrome P450s 2C19 and 3A4
    Tansel Kilicarslan, Robert L. Haining, Allan E. Rettie, Usanda Busto, Rachel F. Tyndale and Edward M. Sellers
    Drug Metabolism and Disposition April 2001, 29 (4) 460-465;
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    Preface
    Werner Kalow Commemorative Issue
    Aspet/aacc Conference
    New Directions in Pharmacogenetics and Ecogenetics
    Genetic Defenses Against Environmental Impacts
    Responses to Infections, Foods, and Environmental Toxicants
    Wendell W. Weber and Robert L. Smith
    Drug Metabolism and Disposition April 2001, 29 (4) 467;
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    Pharmacogenetics in Perspective
    Werner Kalow
    Drug Metabolism and Disposition April 2001, 29 (4) 468-470;
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    From Bcg/Lsh/Ity to Nramp1: Three Decades of Search and Research
    Ellen Buschman and Emil Skamene
    Drug Metabolism and Disposition April 2001, 29 (4) 471-473;
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    The Sole Gateway to Endotoxin Response: How Lps Was Identified as Tlr4, and Its Role in Innate Immunity
    Bruce Beutler and Alexander Poltorak
    Drug Metabolism and Disposition April 2001, 29 (4) 474-478;
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    Genetics of Susceptibility to Infectious Diseases: Tuberculosis and Leprosy as Examples
    Sandrine Marquet and Erwin Schurr
    Drug Metabolism and Disposition April 2001, 29 (4) 479-483;
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    Genetics of Parasitic Infections
    Alain. J. Dessein, Christophe Chevillard, Sandrine Marquet, Sandrine Henri, Dominique Hillaire and Helia Dessein
    Drug Metabolism and Disposition April 2001, 29 (4) 484-488;
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    Pharmacogenetics of Alcohol Response and Alcoholism: The Interplay of Genes and Environmental Factors in Thresholds for Alcoholism
    Marta Radel and David Goldman
    Drug Metabolism and Disposition April 2001, 29 (4) 489-494;
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    Genetics of Iron Storage and Hemochromatosis
    Ernest Beutler, Vincent Felitti, Terri Gelbart and Ngoc Ho
    Drug Metabolism and Disposition April 2001, 29 (4) 495-499;
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    Molecular Genetics of Salt-Sensitivity and Hypertension
    Friedrich C. Luft
    Drug Metabolism and Disposition April 2001, 29 (4) 500-504;
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    Pharmacogenetics of the Vitamin D Receptor and Osteoporosis
    John A. Eisman
    Drug Metabolism and Disposition April 2001, 29 (4) 505-512;
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    Intolerance to Lactose and Other Dietary Sugars
    Dallas M. Swallow, Mark Poulter and Edward J. Hollox
    Drug Metabolism and Disposition April 2001, 29 (4) 513-516;
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    Trimethylaminuria: The Fish Malodor Syndrome
    S. C. Mitchell and R. L. Smith
    Drug Metabolism and Disposition April 2001, 29 (4) 517-521;
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    Interactions between Dietary Chemicals and Human Sulfotransferases—Molecular Mechanisms and Clinical Significance
    Michael W. H. Coughtrie and Laura E. Johnston
    Drug Metabolism and Disposition April 2001, 29 (4) 522-528;
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    Food-Derived Heterocyclic Amine Mutagens: Variable Metabolism and Significance to Humans
    Nigel J. Gooderham, Stephen Murray, Anthony M. Lynch, Masoud Yadollahi-Farsani, Kaicun Zhao, Alan R. Boobis and Donald S. Davies
    Drug Metabolism and Disposition April 2001, 29 (4) 529-534;
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    Genetic Taste Markers and Food Preferences
    Adam Drewnowski, Susan Ahlstrom Henderson and Anne Barratt-Fornell
    Drug Metabolism and Disposition April 2001, 29 (4) 535-538;
  • You have access
    Food Idiosyncrasies: Beetroot and Asparagus
    S. C. Mitchell
    Drug Metabolism and Disposition April 2001, 29 (4) 539-543;
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    Identification of Novel Glutathione Transferases and Polymorphic Variants by Expressed Sequence Tag Database Analysis
    P. G. Board, G. Chelvanayagam, L. S. Jermiin, N. Tetlow, H.-F. Tzeng, M. W. Anders and A. C. Blackburn
    Drug Metabolism and Disposition April 2001, 29 (4) 544-547;
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    Variable CYP2A6-Mediated Nicotine Metabolism Alters Smoking Behavior and Risk
    Rachel F. Tyndale and Edward M. Sellers
    Drug Metabolism and Disposition April 2001, 29 (4) 548-552;
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    Epithelial Sodium Channels and Hypertension
    Yan Ru Su and Anil G. Menon
    Drug Metabolism and Disposition April 2001, 29 (4) 553-556;
  • You have access
    Genetic Variation in β-Adrenergic Receptors and Their Relationship to Susceptibility for Asthma and Therapeutic Response
    Robert P. Erickson and Penelope E. Graves
    Drug Metabolism and Disposition April 2001, 29 (4) 557-561;
  • You have access
    ADH2 and CYP2E1 Genetic Polymorphisms: Risk Factors for Alcohol-Related Birth Defects
    D. Gail McCarver
    Drug Metabolism and Disposition April 2001, 29 (4) 562-565;
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    Serum Paraoxonase (PON1) Isozymes: The Quantitative Analysis of Isozymes Affecting Individual Sensitivity to Environmental Chemicals
    B. N. La Du, S. Billecke, C. Hsu, R. W. Haley and C. A. Broomfield
    Drug Metabolism and Disposition April 2001, 29 (4) 566-569;
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    Implications of Polymorphic Cytochrome P450-Dependent Drug Metabolism for Drug Development
    Magnus Ingelman-Sundberg
    Drug Metabolism and Disposition April 2001, 29 (4) 570-573;
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    Genotype and Severity of Long QT Syndrome
    Jeffrey A. Towbin, Zhiqing Wang and Hua Li
    Drug Metabolism and Disposition April 2001, 29 (4) 574-579;
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    Moving Toward Genetic Profiling in Patient Care: The Scope and Rationale of Pharmacogenetic/Ecogenetic Investigation
    G. Alvan, L. Bertilsson, M.-L. Dahl, M. Ingelman-Sundberg and F. Sjöqvist
    Drug Metabolism and Disposition April 2001, 29 (4) 580-585;
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    Utilization of New Technologies in Drug Trials and Discovery
    Maureen T. Cronin, Mylan Pho, Debjani Dutta, Felix Frueh, Leslie Schwarcz and Thomas Brennan
    Drug Metabolism and Disposition April 2001, 29 (4) 586-590;
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    Pharmacogenetic Application in Drug Development and Clinical Trials
    Michael M. Shi, Michael R. Bleavins and Felix A. de la Iglesia
    Drug Metabolism and Disposition April 2001, 29 (4) 591-595;
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    Pharmacogenetics of Anticancer Agents: Lessons from Amonafide and Irinotecan
    Federico Innocenti, Lalitha Iyer and Mark J. Ratain
    Drug Metabolism and Disposition April 2001, 29 (4) 596-600;
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    Thiopurine Pharmacogenetics: Clinical and Molecular Studies of Thiopurine Methyltransferase
    Richard Weinshilboum
    Drug Metabolism and Disposition April 2001, 29 (4) 601-605;
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    Interethnic Variability in Human Drug Responses
    D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq and A. Mobarek
    Drug Metabolism and Disposition April 2001, 29 (4) 606-610;
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    Prospects for Pharmacogenetics and Ecogenetics in the New Millennium
    Gilbert S. Omenn
    Drug Metabolism and Disposition April 2001, 29 (4) 611-614;

Erratum

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    Correction to “Human 3′-Phosphoadenosine 5′-Phosphosulfate Synthetase: Radiochemical Enzymatic Assay, Biochemical Properties, and Hepatic Variation”
    Drug Metabolism and Disposition April 2001, 29 (4) 466;
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Drug Metabolism and Disposition: 29 (4)
Drug Metabolism and Disposition
Vol. 29, Issue 4
1 Apr 2001
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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