Table of Contents

Articles

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  Cellular Distribution and Handling of Liver-Targeting Preparations in Human Livers Studied by a Liver Lobe Perfusion

  Barbro N. Melgert, Peter Olinga, Betty Weert, Maarten J. H. Slooff, Dirk K. F. Meijer, Klaas Poelstra and Geny M. M. Groothuis

  Drug Metabolism and Disposition April 2001, 29 (4) 361-367;
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  Substrate Inhibition Kinetics for Cytochrome P450-Catalyzed Reactions

  Yuh Lin, Ping Lu, Cuyue Tang, Qin Mei, Grit Sandig, A. David Rodrigues, Thomas H. Rushmore and Magang Shou

  Drug Metabolism and Disposition April 2001, 29 (4) 368-374;
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  S-Naproxen-β-1-O-acyl Glucuronide Degradation Kinetic Studies by Stopped-Flow High-Performance Liquid Chromatography-¹H NMR and High-Performance Liquid Chromatography-UV

  Rasmus W. Mortensen, Olivia Corcoran, Claus Cornett, Ulla G. Sidelmann, John C. Lindon, Jeremy K. Nicholson and Steen Honoré Hansen

  Drug Metabolism and Disposition April 2001, 29 (4) 375-380;
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  Metabolism of Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate (DDB) by Human Liver Microsomes: Characterization of Metabolic Pathways and of Cytochrome P450 Isoforms Involved

  Min-Sun Baek, Ji-Yeon Kim, Seung-Woon Myung, Yong Hyeon Yim, Jin-Hyun Jeong and Dong-Hyun Kim

  Drug Metabolism and Disposition April 2001, 29 (4) 381-388;
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  Mechanism-Based Inhibition of Human Cytochrome P450 1A1 by Rhapontigenin

  Young Jin Chun, Shi Yong Ryu, Tae Cheon Jeong and Mie Young Kim

  Drug Metabolism and Disposition April 2001, 29 (4) 389-393;
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  Carrier-Mediated Hepatobiliary Transport of a Novel Antifolate,N-[4-[(2,4-Diamminopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-Homoglutamic Acid, in Rats

  Yong-Hae Han, Yukio Kato, Yuka Watanabe, Kimio Terao, Yoshinori Asoh and Yuichi Sugiyama

  Drug Metabolism and Disposition April 2001, 29 (4) 394-400;
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  Methemoglobin Oxidation of N-Acetylbenzidine to Form a Sulfinamide

  Terry V. Zenser, Vijaya M. Lakshmi, Fong Fu Hsu and Bernard B. Davis

  Drug Metabolism and Disposition April 2001, 29 (4) 401-406;
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  In Vitro Glucuronidation of the Cyclin-Dependent Kinase Inhibitor Flavopiridol by Rat and Human Liver Microsomes: Involvement of UDP-Glucuronosyltransferases 1A1 and 1A9

  Birgit Hagenauer, Alexandra Salamon, Therese Thalhammer, Olaf Kunert, Ernst Haslinger, Paul Klingler, Adrian M. Senderowicz, Edward A. Sausville and Walter Jäger

  Drug Metabolism and Disposition April 2001, 29 (4) 407-414;
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  Pharmacokinetics and Metabolism of Nateglinide in Humans

  Margaret L. Weaver, Barbara A. Orwig, Lolita C. Rodriguez, Elizabeth D. Graham, Jefferson A. Chin, Michael J. Shapiro, James F. McLeod and James B. Mangold

  Drug Metabolism and Disposition April 2001, 29 (4) 415-421;
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  A Preclinical Pharmacokinetic Study of the Bioreductive Drug AQ4N

  P. M. Loadman, D. J. Swaine, M. C. Bibby, K. J. Welham and L. H. Patterson

  Drug Metabolism and Disposition April 2001, 29 (4) 422-426;
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  Decreases in Phenytoin Hydroxylation Activities Catalyzed by Liver Microsomal Cytochrome P450 Enzymes in Phenytoin-Treated Rats

  Hiroshi Yamazaki, Tomoko Komatsu, Kei Takemoto, Mayuko Saeki, Yoshinori Minami, Yasuro Kawaguchi, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition April 2001, 29 (4) 427-434;
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  The Disposition of Gemifloxacin, a New Fluoroquinolone Antibiotic, in Rats and Dogs

  J. V. Ramji, N. E. Austin, G. W. Boyle, M. H. Chalker, G. Duncan, A. J. Fairless, F. J. Hollis, D. F. McDonnell, T. J. Musick and P. C. Shardlow

  Drug Metabolism and Disposition April 2001, 29 (4) 435-442;
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  Prediction of Midazolam—cyp3a Inhibitors Interaction in the Human Liver from in Vivo/in Vitro Absorption, Distribution, and Metabolism Data

  Katsuhiro Yamano, Koujirou Yamamoto, Masataka Katashima, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Hisakazu Ohtani, Yasufumi Sawada and Tatsuji Iga

  Drug Metabolism and Disposition April 2001, 29 (4) 443-452;
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  Uptake of Teicoplanin by Isolated Rat Hepatocytes: Comparison with in Vivo Hepatic Distribution

  Raquel F. Reinoso, Brian A. Telfer, Beverley S. Brennan and Malcolm Rowland

  Drug Metabolism and Disposition April 2001, 29 (4) 453-459;
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  Flunitrazepam Metabolism by Cytochrome P450s 2C19 and 3A4

  Tansel Kilicarslan, Robert L. Haining, Allan E. Rettie, Usanda Busto, Rachel F. Tyndale and Edward M. Sellers

  Drug Metabolism and Disposition April 2001, 29 (4) 460-465;
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  Preface
  Werner Kalow Commemorative Issue
  Aspet/aacc Conference
  New Directions in Pharmacogenetics and Ecogenetics
  Genetic Defenses Against Environmental Impacts
  Responses to Infections, Foods, and Environmental Toxicants

  Wendell W. Weber and Robert L. Smith

  Drug Metabolism and Disposition April 2001, 29 (4) 467;
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  Pharmacogenetics in Perspective

  Werner Kalow

  Drug Metabolism and Disposition April 2001, 29 (4) 468-470;
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  From Bcg/Lsh/Ity to Nramp1: Three Decades of Search and Research

  Ellen Buschman and Emil Skamene

  Drug Metabolism and Disposition April 2001, 29 (4) 471-473;
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  The Sole Gateway to Endotoxin Response: How Lps Was Identified as Tlr4, and Its Role in Innate Immunity

  Bruce Beutler and Alexander Poltorak

  Drug Metabolism and Disposition April 2001, 29 (4) 474-478;
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  Genetics of Susceptibility to Infectious Diseases: Tuberculosis and Leprosy as Examples

  Sandrine Marquet and Erwin Schurr

  Drug Metabolism and Disposition April 2001, 29 (4) 479-483;
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  Genetics of Parasitic Infections

  Alain. J. Dessein, Christophe Chevillard, Sandrine Marquet, Sandrine Henri, Dominique Hillaire and Helia Dessein

  Drug Metabolism and Disposition April 2001, 29 (4) 484-488;
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  Pharmacogenetics of Alcohol Response and Alcoholism: The Interplay of Genes and Environmental Factors in Thresholds for Alcoholism

  Marta Radel and David Goldman

  Drug Metabolism and Disposition April 2001, 29 (4) 489-494;
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  Genetics of Iron Storage and Hemochromatosis

  Ernest Beutler, Vincent Felitti, Terri Gelbart and Ngoc Ho

  Drug Metabolism and Disposition April 2001, 29 (4) 495-499;
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  Molecular Genetics of Salt-Sensitivity and Hypertension

  Friedrich C. Luft

  Drug Metabolism and Disposition April 2001, 29 (4) 500-504;
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  Pharmacogenetics of the Vitamin D Receptor and Osteoporosis

  John A. Eisman

  Drug Metabolism and Disposition April 2001, 29 (4) 505-512;
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  Intolerance to Lactose and Other Dietary Sugars

  Dallas M. Swallow, Mark Poulter and Edward J. Hollox

  Drug Metabolism and Disposition April 2001, 29 (4) 513-516;
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  Trimethylaminuria: The Fish Malodor Syndrome

  S. C. Mitchell and R. L. Smith

  Drug Metabolism and Disposition April 2001, 29 (4) 517-521;
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  Interactions between Dietary Chemicals and Human Sulfotransferases—Molecular Mechanisms and Clinical Significance

  Michael W. H. Coughtrie and Laura E. Johnston

  Drug Metabolism and Disposition April 2001, 29 (4) 522-528;
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  Food-Derived Heterocyclic Amine Mutagens: Variable Metabolism and Significance to Humans

  Nigel J. Gooderham, Stephen Murray, Anthony M. Lynch, Masoud Yadollahi-Farsani, Kaicun Zhao, Alan R. Boobis and Donald S. Davies

  Drug Metabolism and Disposition April 2001, 29 (4) 529-534;
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  Genetic Taste Markers and Food Preferences

  Adam Drewnowski, Susan Ahlstrom Henderson and Anne Barratt-Fornell

  Drug Metabolism and Disposition April 2001, 29 (4) 535-538;
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  Food Idiosyncrasies: Beetroot and Asparagus

  S. C. Mitchell

  Drug Metabolism and Disposition April 2001, 29 (4) 539-543;
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  Identification of Novel Glutathione Transferases and Polymorphic Variants by Expressed Sequence Tag Database Analysis

  P. G. Board, G. Chelvanayagam, L. S. Jermiin, N. Tetlow, H.-F. Tzeng, M. W. Anders and A. C. Blackburn

  Drug Metabolism and Disposition April 2001, 29 (4) 544-547;
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  Variable CYP2A6-Mediated Nicotine Metabolism Alters Smoking Behavior and Risk

  Rachel F. Tyndale and Edward M. Sellers

  Drug Metabolism and Disposition April 2001, 29 (4) 548-552;
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  Epithelial Sodium Channels and Hypertension

  Yan Ru Su and Anil G. Menon

  Drug Metabolism and Disposition April 2001, 29 (4) 553-556;
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  Genetic Variation in β-Adrenergic Receptors and Their Relationship to Susceptibility for Asthma and Therapeutic Response

  Robert P. Erickson and Penelope E. Graves

  Drug Metabolism and Disposition April 2001, 29 (4) 557-561;
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  ADH2 and CYP2E1 Genetic Polymorphisms: Risk Factors for Alcohol-Related Birth Defects

  D. Gail McCarver

  Drug Metabolism and Disposition April 2001, 29 (4) 562-565;
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  Serum Paraoxonase (PON1) Isozymes: The Quantitative Analysis of Isozymes Affecting Individual Sensitivity to Environmental Chemicals

  B. N. La Du, S. Billecke, C. Hsu, R. W. Haley and C. A. Broomfield

  Drug Metabolism and Disposition April 2001, 29 (4) 566-569;
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  Implications of Polymorphic Cytochrome P450-Dependent Drug Metabolism for Drug Development

  Magnus Ingelman-Sundberg

  Drug Metabolism and Disposition April 2001, 29 (4) 570-573;
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  Genotype and Severity of Long QT Syndrome

  Jeffrey A. Towbin, Zhiqing Wang and Hua Li

  Drug Metabolism and Disposition April 2001, 29 (4) 574-579;
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  Moving Toward Genetic Profiling in Patient Care: The Scope and Rationale of Pharmacogenetic/Ecogenetic Investigation

  G. Alvan, L. Bertilsson, M.-L. Dahl, M. Ingelman-Sundberg and F. Sjöqvist

  Drug Metabolism and Disposition April 2001, 29 (4) 580-585;
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  Utilization of New Technologies in Drug Trials and Discovery

  Maureen T. Cronin, Mylan Pho, Debjani Dutta, Felix Frueh, Leslie Schwarcz and Thomas Brennan

  Drug Metabolism and Disposition April 2001, 29 (4) 586-590;
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  Pharmacogenetic Application in Drug Development and Clinical Trials

  Michael M. Shi, Michael R. Bleavins and Felix A. de la Iglesia

  Drug Metabolism and Disposition April 2001, 29 (4) 591-595;
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  Pharmacogenetics of Anticancer Agents: Lessons from Amonafide and Irinotecan

  Federico Innocenti, Lalitha Iyer and Mark J. Ratain

  Drug Metabolism and Disposition April 2001, 29 (4) 596-600;
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  Thiopurine Pharmacogenetics: Clinical and Molecular Studies of Thiopurine Methyltransferase

  Richard Weinshilboum

  Drug Metabolism and Disposition April 2001, 29 (4) 601-605;
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  Interethnic Variability in Human Drug Responses

  D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq and A. Mobarek

  Drug Metabolism and Disposition April 2001, 29 (4) 606-610;
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  Prospects for Pharmacogenetics and Ecogenetics in the New Millennium

  Gilbert S. Omenn

  Drug Metabolism and Disposition April 2001, 29 (4) 611-614;