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Research ArticleArticle

Trimethylaminuria: The Fish Malodor Syndrome

S. C. Mitchell and R. L. Smith
Drug Metabolism and Disposition April 2001, 29 (4) 517-521;
S. C. Mitchell
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R. L. Smith
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Abstract

The fish malodor syndrome (also known as the fish odor syndrome and trimethylaminuria) is a metabolic disorder characterized by the presence of abnormal amounts of the dietary-derived tertiary amine, trimethylamine, in the urine, sweat, expired air, and other bodily secretions. Trimethylamine itself has the powerful aroma of rotting fish, and this confers upon the sufferer a highly objectionable body odor, which can be destructive to the personal, social, and work life of the affected individual. In recent years, much progress has been made at all levels—clinical, epidemiological, biochemical, and genetic—in our understanding of this unfortunate condition. The present article summarizes this progress, draws attention to the different types of fish malodor syndrome, and highlights the current needs in the treatment of such patients.

Footnotes

  • Send reprint requests to: Dr. R. L. Smith, Section of Molecular Toxicology, Division of Biomedical Sciences, Imperial College School of Medicine, Sir Alexander Fleming Bldg., South Kensington, London SW7 2AZ, England. E-mail: smith{at}dircon.co.uk

  • Abbreviation used is::
    FMO
    flavin monooxygenase
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 29 (4)
Drug Metabolism and Disposition
Vol. 29, Issue 4
1 Apr 2001
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Research ArticleArticle

Trimethylaminuria: The Fish Malodor Syndrome

S. C. Mitchell and R. L. Smith
Drug Metabolism and Disposition April 1, 2001, 29 (4) 517-521;

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Research ArticleArticle

Trimethylaminuria: The Fish Malodor Syndrome

S. C. Mitchell and R. L. Smith
Drug Metabolism and Disposition April 1, 2001, 29 (4) 517-521;
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  • Article
    • Abstract
    • Milestones in the History of the Disorder
    • The First Clinical Reports
    • Recognition of the “Tainted Egg Syndrome” in Chickens
    • The Search for a Human Genetic Polymorphism of TrimethylamineN-Oxidation
    • Biochemical Features of Fish Malodor Syndrome
    • Incidence of Fish Malodor Syndrome
    • Types of Fish Malodor Syndrome
    • Clinical Aspects of the Fish Malodor Syndrome
    • Diagnosis
    • Treatment
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