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Research ArticleArticle

Interethnic Variability in Human Drug Responses

D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq and A. Mobarek
Drug Metabolism and Disposition April 2001, 29 (4) 606-610;
D. A. P. Evans
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H. L. McLeod
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S. Pritchard
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M. Tariq
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A. Mobarek
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Abstract

The scientific study of interethnic differences in responses to drugs has been extant for 80 years. Many of these differences have been described at the phenotypic level, and some have been explained by genetic factors. However, it is frequently difficult to disentangle accurately the hereditary and environmental influences in phenotypic comparisons. This is where the recent developments in knowledge of the genes responsible for drug receptors are starting to make a big impact. The beta 2 adrenoceptor is described; it has three genetic polymorphisms. The different genotypes influence responses to agonists such as albuterol (Salbutamol). New gene frequency data including those for Saudi Arabians, Indians, and Africans are shown. The expanding body of knowledge about genetic (and interethnic) variability in drug receptors is likely to be important in clinical medicine.

Footnotes

  • Send reprint requests to: Emeritus Professor David A. Price Evans, M.D., D.Sc., Ph.D., FRCP, C123 Riyadh, Armed Forces Hospital, P.O. Box 7897, Riyadh 11159, Kingdom of Saudi Arabia. E-mail:dapevans{at}kfshhub.kshrc.edu.sa

  • The collection of blood samples from various ethnic groups was funded by the Research and Ethical committee of the Riyadh Armed Forces Hospital (Chairman Dr. Saleh M. Al Deeb M.D., FRCP Glasgow, FRCP Edinburgh).

  • Abbreviations used are::
    AR
    adrenoceptor
    5′LC
    5′-leader cistron
    FEV1
    forced expiratory volume in 1 s
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 29 (4)
Drug Metabolism and Disposition
Vol. 29, Issue 4
1 Apr 2001
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Research ArticleArticle

Interethnic Variability in Human Drug Responses

D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq and A. Mobarek
Drug Metabolism and Disposition April 1, 2001, 29 (4) 606-610;

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Research ArticleArticle

Interethnic Variability in Human Drug Responses

D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq and A. Mobarek
Drug Metabolism and Disposition April 1, 2001, 29 (4) 606-610;
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  • Article
    • Abstract
    • Phenotypic Interethnic Comparisons
    • The Elucidatory Power of Genetic Polymorphisms
    • The Challenge of Receptors
    • The β2-Adrenergic Receptor
    • The β2-Adrenoceptor Polymorphisms in Different Ethnic Groups
    • Therapeutic Expectations
    • Genetic Factors Influencing β2-Adrenoceptor Function in Human Airways
    • Influence of β2 Adrenergic Receptor Polymorphisms in Nonpulmonary Conditions
    • Other Genetic Polymorphisms in Drug Receptors that may be of Clinical Interest
    • A Voyage of Exploration
    • “The Great Ocean of Truth”
    • Acknowledgments
    • Footnotes
    • References
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