Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Review ArticleMINIREVIEW

Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors

R. N. Hines, Z. Luo, T. Cresteil, X. Ding, R. A. Prough, J. L. Fitzpatrick, S. L. Ripp, K. C. Falkner, N.-L. Ge, A. Levine and C. J. Elferink
Drug Metabolism and Disposition May 2001, 29 (5) 623-633;
R. N. Hines
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Z. Luo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Cresteil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
X. Ding
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. A. Prough
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. L. Fitzpatrick
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. L. Ripp
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. C. Falkner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N.-L. Ge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Levine
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. J. Elferink
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

It is widely recognized that xenobiotic-metabolizing enzymes play a fundamental role in the basic processes of carcinogenesis and toxicity on one hand, and chemoprevention and drug efficacy on the other. Realization that different factors can profoundly affect the expression of these enzymes at the genome level has resulted in an enhanced appreciation of the importance these genes play in our modern industrialized age. There continues to be rapid proliferation of studies addressing the molecular regulation of these genes. The discovery of common signal transduction pathways and transcription factors that dictate tissue and developmental-specific expression, as well as variation in expression within a given tissue, suggest that there may be significant interaction among these various regulatory systems. This report is a summary of a symposium that was part of the Structure, Function and Regulation of Cytochromes P450 and Xenobiotic Metabolizing Enzymes satellite meeting of the 2000 joint meeting of the American Society for Biochemistry and Molecular Biology, the American Society for Pharmacology and Experimental Therapeutics, the French Pharmacological Society, and the Pharmacological Society of Canada held in Boston, Massachusetts. This symposium brought together several speakers who addressed specific receptor-mediated signal transduction pathways involved in the regulation of xenobiotic-metabolizing enzymes, as well as other molecular mechanisms whereby endogenous factors are involved in controlling tissue- and developmental-specific expression.

Footnotes

  • Send reprint requests to: Ronald N. Hines, Ph.D., Department of Pediatrics, Birth Defects Research Center, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226-4801. E-mail: rhines{at}mcw.edu

  • ↵1 Current address: Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

  • This work was supported in part by USPHS Grants CA53106 and ES60143 (R.N.H.); DC02640 and ES07462 (X.D.); DK54774 and ES04244 (R.A.P.); ES07800 and ES06639 (C.J.E.); and a University of Louisville School of Medicine grant (K.C.F.).

  • Abbreviations used are::
    P450
    cytochrome P450
    AhR
    aryl hydrocarbon receptor
    bp
    base pair
    bHLH
    basic helix-loop-helix
    C/EBP
    CCAAT/enhancer binding protein
    CDK
    cyclin-dependent kinase
    CKI
    CDK inhibitor
    DHEA
    dehydroepiandrosterone
    EMAS
    electrophoretic mobility shift assay
    FMO
    flavin-containing monooxygenase
    GR
    glucocorticoid receptor
    GRE
    glucocorticoid-responsive element
    HNF
    hepatocyte nuclear factor
    NFI
    nuclear factor I
    NPTA
    nasal-predominant transcriptional activity
    PAS
    Period/Ah receptor nuclear translocator/Single-minded
    PPARα
    peroxisome proliferator-activated receptor alpha
    pRb
    retinoblastoma protein
    PXR
    pregnane X receptor
    t-Bu-DEX
    dexamethasonet-butyl acetate
    TCDD
    2,3,7,8-tetrachlorodibenzo-p-dioxin
    TTF1
    thyroid transcription factor 1
    YY1
    ying yang 1
    • Received December 1, 2000.
    • Accepted February 2, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 29 (5)
Drug Metabolism and Disposition
Vol. 29, Issue 5
1 May 2001
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Review ArticleMINIREVIEW

Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors

R. N. Hines, Z. Luo, T. Cresteil, X. Ding, R. A. Prough, J. L. Fitzpatrick, S. L. Ripp, K. C. Falkner, N.-L. Ge, A. Levine and C. J. Elferink
Drug Metabolism and Disposition May 1, 2001, 29 (5) 623-633;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Review ArticleMINIREVIEW

Molecular Regulation of Genes Encoding Xenobiotic-Metabolizing Enzymes: Mechanisms Involving Endogenous Factors

R. N. Hines, Z. Luo, T. Cresteil, X. Ding, R. A. Prough, J. L. Fitzpatrick, S. L. Ripp, K. C. Falkner, N.-L. Ge, A. Levine and C. J. Elferink
Drug Metabolism and Disposition May 1, 2001, 29 (5) 623-633;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Onset of Cytochrome P450 Protein Expression in the Human Liver during the Perinatal Period (T.C.)
    • Molecular Mechanisms Controlling Flavin-Containing Monooxygenase Tissue-Specific Expression (R.N.H., Z.L., K.M.)
    • Transcriptional Regulation of the CYP1A2,CYP2A, and CYP2G1 Genes in the Olfactory Mucosa (X.D.)
    • Regulation of Drug-Metabolizing Enzymes by Adrenal Steroids (R.A.P., J.L.F., S.L.R., K.C.F.)
    • Ah Receptor and Retinoblastoma Protein Interactions: Implications for Cell Cycle Control (N.-L.G., A.L., C.J.E.)
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Immune Dysregulation in Acute Liver Failure
  • Mechanistic Biomarkers in Acetaminophen Translation
  • History of Canadian content in the pages of DMD
Show more Minireview

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics