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Research ArticleArticle

An Assessment of Human Liver-Derived in Vitro Systems to Predict the in Vivo Metabolism and Clearance of Almokalant

Tommy B. Andersson, Helena Sjöberg, Kurt-Jürgen Hoffmann, Alan R. Boobis, Patricia Watts, Robert J. Edwards, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria J. Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Peter S. Goldfarb, David F. V. Lewis, Laurent Corcos, André Guillouzo, Päivi Taavitsainen and Olavi Pelkonen
Drug Metabolism and Disposition May 2001, 29 (5) 712-720;
Tommy B. Andersson
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Helena Sjöberg
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Kurt-Jürgen Hoffmann
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Alan R. Boobis
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Patricia Watts
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Robert J. Edwards
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Brian G. Lake
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Roger J. Price
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Anthony B. Renwick
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Maria J. Gómez-Lechón
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José V. Castell
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Magnus Ingelman-Sundberg
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Mats Hidestrand
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Peter S. Goldfarb
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David F. V. Lewis
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Laurent Corcos
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André Guillouzo
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Päivi Taavitsainen
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Olavi Pelkonen
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Article Information

vol. 29 no. 5 712-720
PubMed 
11302938

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 19, 2000
  • Accepted January 9, 2001
  • Published online May 1, 2001.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tommy B. Andersson1,
  2. Helena Sjöberg1,
  3. Kurt-Jürgen Hoffmann1,
  4. Alan R. Boobis2,
  5. Patricia Watts2,
  6. Robert J. Edwards2,
  7. Brian G. Lake3,
  8. Roger J. Price3,
  9. Anthony B. Renwick,
  10. Maria J. Gómez-Lechón4,
  11. José V. Castell4,
  12. Magnus Ingelman-Sundberg5,
  13. Mats Hidestrand5,
  14. Peter S. Goldfarb6,
  15. David F. V. Lewis6,
  16. Laurent Corcos7,
  17. André Guillouzo7,
  18. Päivi Taavitsainen8 and
  19. Olavi Pelkonen8
  1. 1Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca Research and Development, Mölndal, Sweden (T.B.A., H.S., K.-J.H.); 2Imperial College School of Medicine, Department of Medicine, Section on Clinical Pharmacology, London, United Kingdom (A.R.B., P.W., R.J.E.); 3TNO BIBRA International Ltd., Carshalton, Surrey, United Kingdom (B.G.L., R.J.P.); 4Unidad Hepatologı́a Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia, Spain (M.J.G.-L., J.V.C.); 5Karolinska Institutet, Institute of Molecular Medicine, Division of Molecular Toxicology, Stockholm, Sweden (M.I.-S., M.H.); 6University of Surrey School of Biological Sciences, Guildford, Surrey, United Kingdom (P.S.G., D.F.V.L.); 7University of Rennes, Faculty of Pharmacy, INSERM U456, Rennes, France (L.C., A.G.); 8University of Oulu, Department of Pharmacology and Toxicology, Oulu, Finland (P.T., O.P.)
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    Drug Metabolism and Disposition: 29 (5)
    Drug Metabolism and Disposition
    Vol. 29, Issue 5
    1 May 2001
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    Research ArticleArticle

    An Assessment of Human Liver-Derived in Vitro Systems to Predict the in Vivo Metabolism and Clearance of Almokalant

    Tommy B. Andersson, Helena Sjöberg, Kurt-Jürgen Hoffmann, Alan R. Boobis, Patricia Watts, Robert J. Edwards, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria J. Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Peter S. Goldfarb, David F. V. Lewis, Laurent Corcos, André Guillouzo, Päivi Taavitsainen and Olavi Pelkonen
    Drug Metabolism and Disposition May 1, 2001, 29 (5) 712-720;

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    Research ArticleArticle

    An Assessment of Human Liver-Derived in Vitro Systems to Predict the in Vivo Metabolism and Clearance of Almokalant

    Tommy B. Andersson, Helena Sjöberg, Kurt-Jürgen Hoffmann, Alan R. Boobis, Patricia Watts, Robert J. Edwards, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria J. Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Peter S. Goldfarb, David F. V. Lewis, Laurent Corcos, André Guillouzo, Päivi Taavitsainen and Olavi Pelkonen
    Drug Metabolism and Disposition May 1, 2001, 29 (5) 712-720;
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