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Drug Metabolism & Disposition

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Table of Contents

September 01, 2001; Volume 29,Issue 9

Short Communication

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    In Vitro Characterization of the Inhibition Profile of Loratadine, Desloratadine, and 3-OH-Desloratadine for Five Human Cytochrome P-450 Enzymes
    Mary E. Barecki, Christopher N. Casciano, William W. Johnson and Robert P. Clement
    Drug Metabolism and Disposition September 2001, 29 (9) 1173-1175;

Articles

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    Metabolic Activation of Polycyclic Aromatic Hydrocarbons and Other Procarcinogens by Cytochromes P450 1A1 and P450 1B1 Allelic Variants and Other Human Cytochromes P450 in Salmonella typhimurium NM2009
    Tsutomu Shimada, Yoshimitsu Oda, Elizabeth M. J. Gillam, F. Peter Guengerich and Kiyoshi Inoue
    Drug Metabolism and Disposition September 2001, 29 (9) 1176-1182;
  • You have access
    Simultaneous Pharmacokinetic Modeling of Cocaine and Its Metabolites, Norcocaine and Benzoylecgonine, after Intravenous and Oral Administration in Rats
    Lei Sun and Chyan E. Lau
    Drug Metabolism and Disposition September 2001, 29 (9) 1183-1189;
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    Mechanism-Based Inactivation of CYP2C11 by Diclofenac
    Yasuhiro Masubuchi, Atsushi Ose and Toshiharu Horie
    Drug Metabolism and Disposition September 2001, 29 (9) 1190-1195;
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    The Use of 3-[2-(N,N-Diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a Specific CYP2D6 Probe in Human Liver Microsomes
    Nathalie Chauret, Barry Dobbs, Rebecca L. Lackman, Kevin Bateman, Deborah A. Nicoll-Griffith, David M. Stresser, Joseph M. Ackermann, Stephanie D. Turner, Vaughn P. Miller and Charles L. Crespi
    Drug Metabolism and Disposition September 2001, 29 (9) 1196-1200;
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    Metabolism of Chlorpyrifos by Human Cytochrome P450 Isoforms and Human, Mouse, and Rat Liver Microsomes
    Jun Tang, Yan Cao, Randy L. Rose, Alan A. Brimfield, Diana Dai, Joyce A. Goldstein and Ernest Hodgson
    Drug Metabolism and Disposition September 2001, 29 (9) 1201-1204;
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    Genetic Polymorphism of Cytochrome P450 3A5 in Chinese
    Fang-Chun Chou, Shwu-Jen Tzeng and Jin-ding Huang
    Drug Metabolism and Disposition September 2001, 29 (9) 1205-1209;
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    Effect of α-Fluorination of Valproic Acid on Valproyl-S-Acyl-CoA Formation in Vivo in Rats
    Mark P. Grillo, Grazia Chiellini, Marco Tonelli and Leslie Z. Benet
    Drug Metabolism and Disposition September 2001, 29 (9) 1210-1215;
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    Metabolism of Vanoxerine, 1-[2-[bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) Piperazine, by Human Cytochrome P450 Enzymes
    Svetlana A. Cherstniakova, Daoqin Bi, Daniel R. Fuller, Jurij Z. Mojsiak, Jerry M. Collins and Louis R. Cantilena
    Drug Metabolism and Disposition September 2001, 29 (9) 1216-1220;
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    Depentylation of the Rat Esophageal Carcinogen, Methyl-n-pentylnitrosamine, by Microsomes from Various Human and Rat Tissues and by Cytochrome P450 2A3
    Sheng Chong Chen, Lin Zhou, Xinxin Ding and Sidney S. Mirvish
    Drug Metabolism and Disposition September 2001, 29 (9) 1221-1228;
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    Induction of Cytochromes P450 1A1 and 1B1 by Emodin in Human Lung Adenocarcinoma Cell Line CL5
    Hui-Wu Wang, Ta-Liang Chen, Pan-Chyr Yang and Tzuu-Huei Ueng
    Drug Metabolism and Disposition September 2001, 29 (9) 1229-1235;
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    Role of Induction of Specific Hepatic Cytochrome P450 Isoforms in Epoxidation of 4-Vinylcyclohexene
    S. M. Fontaine, P. B. Hoyer, J. R. Halpert and I. G. Sipes
    Drug Metabolism and Disposition September 2001, 29 (9) 1236-1242;
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    Cytochrome P450 Induction in Rat Hepatocytes Assessed by Quantitative Real-Time Reverse-Transcription Polymerase Chain Reaction and the RNA Invasive Cleavage Assay
    Michael E. Burczynski, Michael McMillian, James B. Parker, Stewart Bryant, Angelique Leone, Elfrida R. Grant, Jacqueline M. Thorne, Zhong Zhong, Robert A. Zivin and Mark D. Johnson
    Drug Metabolism and Disposition September 2001, 29 (9) 1243-1250;
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In this issue

Drug Metabolism and Disposition: 29 (9)
Drug Metabolism and Disposition
Vol. 29, Issue 9
1 Sep 2001
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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