Abstract
Pretreatment with lead nitrate of rats intoxicated with Cd4 exerted a significant protective effect against several damaging effects of the haloalkane. Liver microsomal lipid peroxidation. one of the earliest phenomena in CCI4 intoxication. was clearly inhibited by pretreating the rats with lead. The heavy metal also ameliorated the polyribosomal disaggregation caused by CCI4. Fatty infiltration in the liver. measured by the triglyceride content in the organ. was less pronounced in CCI4-poisoned rats pretreated with lead than in animals treated with the haloalkane alone. Lipid metabolism was also studied by means of Triton WR 1 339-induced hypertriglyceridemia to examine the state of triglyceride secretion from liver into plasma; the higher level of plasma triglyceride in the lead-pretreated rats further strenghtened the results obtained on the secretion experiments. Finally. CCI4-induced liver necrosis. as measured by serum transaminases and histological examination. was partially prevented by lead. The mechanism by which lead. an inhibitor of the drug-metabolizing enzyme system. interferes with CCL, intoxication. is discussed.
Footnotes
- Received December 17, 1974.
- Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics
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