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Drug Metabolism & Disposition

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Table of Contents

January 01, 2002; Volume 30,Issue 1

Short Communications

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    Desacetyl-Diltiazem Displays Severalfold Higher Affinity to CYP2D6 Compared with CYP3A4
    Espen Molden, Anders Åsberg and Hege Christensen
    Drug Metabolism and Disposition January 2002, 30 (1) 1-3; DOI: https://doi.org/10.1124/dmd.30.1.1
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    Real-Time Quantitative Polymerase Chain Reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA Levels in Caco-2 Cell Lines, Human Duodenal Enterocytes, Normal Colorectal Tissues, and Colorectal Adenocarcinomas
    Tsutomu Nakamura, Toshiyuki Sakaeda, Nobuko Ohmoto, Takao Tamura, Nobuo Aoyama, Toshiro Shirakawa, Takashi Kamigaki, Takeshi Nakamura, Ke Ih Kim, Soo Ryang Kim, Yoshikazu Kuroda, Masafumi Matsuo, Masato Kasuga and Katsuhiko Okumura
    Drug Metabolism and Disposition January 2002, 30 (1) 4-6; DOI: https://doi.org/10.1124/dmd.30.1.4

Articles

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    Computational Models for Cytochrome P450: A Predictive Electronic Model for Aromatic Oxidation and Hydrogen Atom Abstraction
    Jeffrey P. Jones, Michael Mysinger and Kenneth Ray Korzekwa
    Drug Metabolism and Disposition January 2002, 30 (1) 7-12; DOI: https://doi.org/10.1124/dmd.30.1.7
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    The Anti-Influenza Drug Oseltamivir Exhibits Low Potential to Induce Pharmacokinetic Drug Interactions via Renal Secretion—Correlation of in Vivo and in Vitro Studies
    George Hill, Tomas Cihlar, Charles Oo, Edmund S. Ho, Ken Prior, Hugh Wiltshire, Jo Barrett, Baulian Liu and Penny Ward
    Drug Metabolism and Disposition January 2002, 30 (1) 13-19; DOI: https://doi.org/10.1124/dmd.30.1.13
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    Induction of Multidrug Resistance-1 and Cytochrome P450 mRNAs in Human Mononuclear Cells by Rifampin
    Ali Asghar, J. Christopher Gorski, Barbara Haehner-Daniels and Stephen D. Hall
    Drug Metabolism and Disposition January 2002, 30 (1) 20-26; DOI: https://doi.org/10.1124/dmd.30.1.20
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    The Disposition, Metabolism, and Pharmacokinetics of a Selective Metabotropic Glutamate Receptor Agonist in Rats and Dogs
    Jason T. Johnson, Edward L. Mattiuz, Sylvia H. Chay, Jennifer L. Herman, William J. Wheeler, Kelem Kassahun, Steven P. Swanson and Diane L. Phillips
    Drug Metabolism and Disposition January 2002, 30 (1) 27-33; DOI: https://doi.org/10.1124/dmd.30.1.27
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    Identification of Active Flavin-Containing Monooxygenase Isoform 2 in Human Lung and Characterization of Expressed Protein
    Sharon K. Krueger, Sarah R. Martin, Mei-Fei Yueh, Clifford B. Pereira and David E. Williams
    Drug Metabolism and Disposition January 2002, 30 (1) 34-41; DOI: https://doi.org/10.1124/dmd.30.1.34
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    The Role of Cytokines in the Depression of CYP1A Activity Using Cultured Astrocytes as an in Vitro Model of Inflammation in the Central Nervous System
    Tara E. Nicholson and Kenneth W. Renton
    Drug Metabolism and Disposition January 2002, 30 (1) 42-46; DOI: https://doi.org/10.1124/dmd.30.1.42
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    Plasma Pharmacokinetics and Tissue Distribution of aN-Pyrrolo- [1,2-c]Imidazolylphenyl Sulfonamide in Rats
    Mehran F. Moghaddam, Matthew S. Bogdanffy, Alethia Brown, Kim Ford and Lamaat Shalaby
    Drug Metabolism and Disposition January 2002, 30 (1) 47-54; DOI: https://doi.org/10.1124/dmd.30.1.47
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    Studies on the Reactivity of Clofibryl-S-Acyl-CoA Thioester with Glutathione in Vitro
    Mark P. Grillo and Leslie Z. Benet
    Drug Metabolism and Disposition January 2002, 30 (1) 55-62; DOI: https://doi.org/10.1124/dmd.30.1.55
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    Effect of Multiple Dosing of Ketoconazole on Pharmacokinetics of Midazolam, a Cytochrome P-450 3A Substrate in Beagle Dogs
    Masanori Kuroha, Akinori Azumano, Yoji Kuze, Minoru Shimoda and Eiichi Kokue
    Drug Metabolism and Disposition January 2002, 30 (1) 63-68; DOI: https://doi.org/10.1124/dmd.30.1.63
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    Effects of Aldehyde Dehydrogenase-2 Genetic Polymorphisms on Metabolism of Structurally Different Aldehydes in Human Liver
    Rui-Sheng Wang, Tamie Nakajima, Toshihiro Kawamoto and Takeshi Honma
    Drug Metabolism and Disposition January 2002, 30 (1) 69-73; DOI: https://doi.org/10.1124/dmd.30.1.69
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    CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-
    dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O-Demethylation
    Fatih M. Uckun, Jason Thoen, Hao Chen, Elise Sudbeck, Chen Mao, Ravi Malaviya, Xing-Ping Liu and Chun-Lin Chen
    Drug Metabolism and Disposition January 2002, 30 (1) 74-85; DOI: https://doi.org/10.1124/dmd.30.1.74
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    Combined Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Cytochrome P450 2B6 Substrates and Protein Homology Modeling
    Qinmi Wang and James R. Halpert
    Drug Metabolism and Disposition January 2002, 30 (1) 86-95; DOI: https://doi.org/10.1124/dmd.30.1.86

Accelerated Communication

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    A Pharmacophore for Human Pregnane X Receptor Ligands
    Sean Ekins and Jon A. Erickson
    Drug Metabolism and Disposition January 2002, 30 (1) 96-99; DOI: https://doi.org/10.1124/dmd.30.1.96

Letter to the Editor

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    Pig and Minipig Cytochromes P450
    Pavel Anzenbacher, Eva Anzenbacherová, Roman Zuber, Pavel Soucek and F. Peter Guengerich
    Drug Metabolism and Disposition January 2002, 30 (1) 100-102; DOI: https://doi.org/10.1124/dmd.30.1.100
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Drug Metabolism and Disposition: 30 (1)
Drug Metabolism and Disposition
Vol. 30, Issue 1
1 Jan 2002
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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