Table of Contents

Articles

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  Computational Models for Cytochrome P450: A Predictive Electronic Model for Aromatic Oxidation and Hydrogen Atom Abstraction

  Jeffrey P. Jones, Michael Mysinger and Kenneth Ray Korzekwa

  Drug Metabolism and Disposition January 2002, 30 (1) 7-12; DOI: https://doi.org/10.1124/dmd.30.1.7
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  The Anti-Influenza Drug Oseltamivir Exhibits Low Potential to Induce Pharmacokinetic Drug Interactions via Renal Secretion—Correlation of in Vivo and in Vitro Studies

  George Hill, Tomas Cihlar, Charles Oo, Edmund S. Ho, Ken Prior, Hugh Wiltshire, Jo Barrett, Baulian Liu and Penny Ward

  Drug Metabolism and Disposition January 2002, 30 (1) 13-19; DOI: https://doi.org/10.1124/dmd.30.1.13
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  Induction of Multidrug Resistance-1 and Cytochrome P450 mRNAs in Human Mononuclear Cells by Rifampin

  Ali Asghar, J. Christopher Gorski, Barbara Haehner-Daniels and Stephen D. Hall

  Drug Metabolism and Disposition January 2002, 30 (1) 20-26; DOI: https://doi.org/10.1124/dmd.30.1.20
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  The Disposition, Metabolism, and Pharmacokinetics of a Selective Metabotropic Glutamate Receptor Agonist in Rats and Dogs

  Jason T. Johnson, Edward L. Mattiuz, Sylvia H. Chay, Jennifer L. Herman, William J. Wheeler, Kelem Kassahun, Steven P. Swanson and Diane L. Phillips

  Drug Metabolism and Disposition January 2002, 30 (1) 27-33; DOI: https://doi.org/10.1124/dmd.30.1.27
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  Identification of Active Flavin-Containing Monooxygenase Isoform 2 in Human Lung and Characterization of Expressed Protein

  Sharon K. Krueger, Sarah R. Martin, Mei-Fei Yueh, Clifford B. Pereira and David E. Williams

  Drug Metabolism and Disposition January 2002, 30 (1) 34-41; DOI: https://doi.org/10.1124/dmd.30.1.34
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  The Role of Cytokines in the Depression of CYP1A Activity Using Cultured Astrocytes as an in Vitro Model of Inflammation in the Central Nervous System

  Tara E. Nicholson and Kenneth W. Renton

  Drug Metabolism and Disposition January 2002, 30 (1) 42-46; DOI: https://doi.org/10.1124/dmd.30.1.42
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  Plasma Pharmacokinetics and Tissue Distribution of aN-Pyrrolo- [1,2-c]Imidazolylphenyl Sulfonamide in Rats

  Mehran F. Moghaddam, Matthew S. Bogdanffy, Alethia Brown, Kim Ford and Lamaat Shalaby

  Drug Metabolism and Disposition January 2002, 30 (1) 47-54; DOI: https://doi.org/10.1124/dmd.30.1.47
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  Studies on the Reactivity of Clofibryl-S-Acyl-CoA Thioester with Glutathione in Vitro

  Mark P. Grillo and Leslie Z. Benet

  Drug Metabolism and Disposition January 2002, 30 (1) 55-62; DOI: https://doi.org/10.1124/dmd.30.1.55
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  Effect of Multiple Dosing of Ketoconazole on Pharmacokinetics of Midazolam, a Cytochrome P-450 3A Substrate in Beagle Dogs

  Masanori Kuroha, Akinori Azumano, Yoji Kuze, Minoru Shimoda and Eiichi Kokue

  Drug Metabolism and Disposition January 2002, 30 (1) 63-68; DOI: https://doi.org/10.1124/dmd.30.1.63
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  Effects of Aldehyde Dehydrogenase-2 Genetic Polymorphisms on Metabolism of Structurally Different Aldehydes in Human Liver

  Rui-Sheng Wang, Tamie Nakajima, Toshihiro Kawamoto and Takeshi Honma

  Drug Metabolism and Disposition January 2002, 30 (1) 69-73; DOI: https://doi.org/10.1124/dmd.30.1.69
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  CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-
  dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O-Demethylation

  Fatih M. Uckun, Jason Thoen, Hao Chen, Elise Sudbeck, Chen Mao, Ravi Malaviya, Xing-Ping Liu and Chun-Lin Chen

  Drug Metabolism and Disposition January 2002, 30 (1) 74-85; DOI: https://doi.org/10.1124/dmd.30.1.74
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  Combined Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Cytochrome P450 2B6 Substrates and Protein Homology Modeling

  Qinmi Wang and James R. Halpert

  Drug Metabolism and Disposition January 2002, 30 (1) 86-95; DOI: https://doi.org/10.1124/dmd.30.1.86