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Drug Metabolism & Disposition

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Table of Contents

October 01, 2002; Volume 30,Issue 10

MINIREVIEW

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    Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation
    John R. Cashman and Jun Zhang
    Drug Metabolism and Disposition October 2002, 30 (10) 1043-1052; DOI: https://doi.org/10.1124/dmd.30.10.1043
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    Reactive Intermediates and The Dynamics of Glutathione Transferases
    Rosanna Rinaldi, Erik Eliasson, Stellan Swedmark and Ralf Morgenstern
    Drug Metabolism and Disposition October 2002, 30 (10) 1053-1058; DOI: https://doi.org/10.1124/dmd.30.10.1053

Short Communication

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    Effective Dosing Regimen of 1-Aminobenzotriazole for Inhibition of Antipyrine Clearance in Rats, Dogs, and Monkeys
    Suresh K. Balani, Tong Zhu, Tian J. Yang, Zhi Liu, Bing He and Frank W. Lee
    Drug Metabolism and Disposition October 2002, 30 (10) 1059-1062; DOI: https://doi.org/10.1124/dmd.30.10.1059

Articles

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    Metabolic Activation of 4-Hydroxyanisole by Isolated Rat Hepatocytes
    M. Y. Moridani, S. S. Cheon, S. Khan and P. J. O'Brien
    Drug Metabolism and Disposition October 2002, 30 (10) 1063-1069; DOI: https://doi.org/10.1124/dmd.30.10.1063
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    Quaternary Ammonium-Linked Glucuronidation of 1-Substituted Imidazoles by Liver Microsomes: Interspecies Differences and Structure-Metabolism Relationships
    Sarvesh C. Vashishtha, Edward M. Hawes, Denis J. McCann, Omar Ghosheh and Lawrence Hogg
    Drug Metabolism and Disposition October 2002, 30 (10) 1070-1076; DOI: https://doi.org/10.1124/dmd.30.10.1070
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    In Vitro Metabolism ofR(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a Cannabinoid Receptor Agonist
    Qiang Zhang, Peng Ma, Marcus Iszard, Richard B. Cole, Weiqun Wang and Guangdi Wang
    Drug Metabolism and Disposition October 2002, 30 (10) 1077-1086; DOI: https://doi.org/10.1124/dmd.30.10.1077
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    Flavin-Containing Monooxygenase Activity in Hepatocytes and Microsomes: In Vitro Characterization and In Vivo Scaling of Benzydamine Clearance
    Michael B. Fisher, Kwansik Yoon, Marcie L. Vaughn, Timothy J. Strelevitz and Robert S. Foti
    Drug Metabolism and Disposition October 2002, 30 (10) 1087-1093; DOI: https://doi.org/10.1124/dmd.30.10.1087
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    Implication of P450-Metabolite Complex Formation in the Nonlinear Pharmacokinetics and Metabolic Fate of (±)-(1′R*,3R*)-3-Phenyl-1-[(1′,2′,3′,4′-tetrahydro-5′,6′-methylene-dioxy-1′-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in Dogs
    James L. Ferrero, Samuel B. Thomas, Kennan C. Marsh, A. David Rodrigues, John T. Uchic and Alex M. Buko
    Drug Metabolism and Disposition October 2002, 30 (10) 1094-1101; DOI: https://doi.org/10.1124/dmd.30.10.1094
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    Inhibitory Effects of Tricyclic Antidepressants (TCAs) on Human Cytochrome P450 Enzymes in Vitro: Mechanism of Drug Interaction between TCAs and Phenytoin
    Jae-Gook Shin, Ji-Young Park, Min-Jung Kim, Ji-Hong Shon, Young-Ran Yoon, In-June Cha, Sang-Seop Lee, Se-Wook Oh, Sang-Woo Kim and David A. Flockhart
    Drug Metabolism and Disposition October 2002, 30 (10) 1102-1107; DOI: https://doi.org/10.1124/dmd.30.10.1102
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    Interindividual Variability and Tissue-Specificity in the Expression of Cytochrome P450 3A mRNA
    Ina Koch, Regina Weil, Renzo Wolbold, Jürgen Brockmöller, Elisabeth Hustert, Oliver Burk, Andreas Nuessler, Peter Neuhaus, Michel Eichelbaum, Ulrich Zanger and Leszek Wojnowski
    Drug Metabolism and Disposition October 2002, 30 (10) 1108-1114; DOI: https://doi.org/10.1124/dmd.30.10.1108
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    Metabolism and Pharmacokinetics ofN′-Nitrosonornicotine in the Patas Monkey
    Pramod Upadhyaya, Cheryl L. Zimmerman and Stephen S. Hecht
    Drug Metabolism and Disposition October 2002, 30 (10) 1115-1122; DOI: https://doi.org/10.1124/dmd.30.10.1115
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    Cefazolin Administration and 2-Methyl-1,3,4-Thiadiazole-5-Thiol in Human Tissue: Possible Relationship to Hypoprothrombinemia
    Thomas C. Wood, Kenneth L. Johnson, Stephen Naylor and Richard M. Weinshilboum
    Drug Metabolism and Disposition October 2002, 30 (10) 1123-1128; DOI: https://doi.org/10.1124/dmd.30.10.1123
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    Comparison of in Vitro Preparations for Semi-Quantitative Prediction of in Vivo Drug Metabolism
    I. A. M. de Graaf, C. E. van Meijeren, F. Pektaş and H. J. Koster
    Drug Metabolism and Disposition October 2002, 30 (10) 1129-1136; DOI: https://doi.org/10.1124/dmd.30.10.1129
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    Sulfoxides as Urinary Metabolites ofS-Allyl-l-Cysteine in Rats: Evidence for the Involvement of Flavin-Containing Monooxygenases
    Renee J. Krause, Steven C. Glocke and Adnan A. Elfarra
    Drug Metabolism and Disposition October 2002, 30 (10) 1137-1142; DOI: https://doi.org/10.1124/dmd.30.10.1137
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    Diclofenac-Induced Inactivation of CYP3A4 and Its Stimulation by Quinidine
    Yasuhiro Masubuchi, Atsushi Ose and Toshiharu Horie
    Drug Metabolism and Disposition October 2002, 30 (10) 1143-1148; DOI: https://doi.org/10.1124/dmd.30.10.1143
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Drug Metabolism and Disposition: 30 (10)
Drug Metabolism and Disposition
Vol. 30, Issue 10
1 Oct 2002
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  • MINIREVIEW
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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