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Review ArticleMINIREVIEW

Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation

John R. Cashman and Jun Zhang
Drug Metabolism and Disposition October 2002, 30 (10) 1043-1052; DOI: https://doi.org/10.1124/dmd.30.10.1043
John R. Cashman
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Drug Metabolism and Disposition: 30 (10)
Drug Metabolism and Disposition
Vol. 30, Issue 10
1 Oct 2002
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Review ArticleMINIREVIEW

Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation

John R. Cashman and Jun Zhang
Drug Metabolism and Disposition October 1, 2002, 30 (10) 1043-1052; DOI: https://doi.org/10.1124/dmd.30.10.1043

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Review ArticleMINIREVIEW

Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation

John R. Cashman and Jun Zhang
Drug Metabolism and Disposition October 1, 2002, 30 (10) 1043-1052; DOI: https://doi.org/10.1124/dmd.30.10.1043
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  • Article
    • Abstract
    • Hepatic Human FMO
    • Human FMO3 Substrate Specificity
    • Extra Hepatic Human FMO
    • Interindividual Variability of Human FMO3 Functional Activity: In Vitro Considerations
    • Interindividual Variability of Human FMO3 Functional Activity: In Vivo Considerations
    • FMO Gene Organization
    • Biochemical Properties of FMO: Modulation and Regulation
    • Common Polymorphisms of Human FMO3 Genes and Haplotype Analysis in Ethnic Groups
    • Human FMO3 Polymorphism Analysis and Other Considerations
    • An Example of a Human FMO3 Polymorphism Associated with Ethnicity
    • Rare Human FMO3 Mutations
    • Human FMO3 Variants Associated with Transient Trimethylaminuria
    • Conclusions
    • Acknowledgments
    • Note Added in Proof.
    • Footnotes
    • References
    • Footnotes
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