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Quaternary Ammonium-Linked Glucuronidation of 1-Substituted Imidazoles by Liver Microsomes: Interspecies Differences and Structure-Metabolism Relationships

Sarvesh C. Vashishtha, Edward M. Hawes, Denis J. McCann, Omar Ghosheh and Lawrence Hogg
Drug Metabolism and Disposition October 2002, 30 (10) 1070-1076; DOI: https://doi.org/10.1124/dmd.30.10.1070

Article Information

vol. 30 no. 10 1070-1076
DOI 
https://doi.org/10.1124/dmd.30.10.1070
PubMed 
12228182
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 15, 2002
  • Accepted June 19, 2002
  • Published online October 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sarvesh C. Vashishtha1,1,
  2. Edward M. Hawes1,
  3. Denis J. McCann2,3,
  4. Omar Ghosheh1 and
  5. Lawrence Hogg1,2
  1. 1Drug Metabolism and Drug Disposition Group (S.C.V., E.M.H., O.G., L.H.), 2University of Saskatchewan, and PharmaLytics (L.H.), Saskatoon, Saskatchewan, Canada; and 3Drug Disposition and Metabolism Department, AstraZeneca, Wilmington, DE (D.J.M.)
  1. Sarvesh Vashishtha, Wyeth Research, S3223A, 500 Arcola Road, Collegeville, PA 19426-3930. E-mail:vashiss{at}labs.wyeth.com
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Research ArticleArticle

Quaternary Ammonium-Linked Glucuronidation of 1-Substituted Imidazoles by Liver Microsomes: Interspecies Differences and Structure-Metabolism Relationships

Sarvesh C. Vashishtha, Edward M. Hawes, Denis J. McCann, Omar Ghosheh and Lawrence Hogg
Drug Metabolism and Disposition October 1, 2002, 30 (10) 1070-1076; DOI: https://doi.org/10.1124/dmd.30.10.1070
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