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History
- Received August 14, 2001
- Accepted March 26, 2002
- Published online October 1, 2002.
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The American Society for Pharmacology and Experimental Therapeutics
Author Information
- James L. Ferrero1,
- Samuel B. Thomas2,3,
- Kennan C. Marsh,
- A. David Rodrigues4,
- John T. Uchic2 and
- Alex M. Buko5
- 1Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla, California (J.L.F.); 2Department of Drug Metabolism, Abbott Laboratories, Abbott Park, Illinois (J.T.U., S.B.T.); 3Amgen, Thousand Oaks, California (S.B.T.); 4Department of Preclinical Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania (A.D.R.); and 5Department of Analytical Biochemistry, Biogen, Cambridge, Massachusetts (A.M.B.)
- Dr. James Ferrero, Pfizer Global RND, 10724 Science Center Dr., Bldg CB3, San Diego, CA 92121. E-mail: james.ferrero{at}pfizer.com
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Implication of P450-Metabolite Complex Formation in the Nonlinear Pharmacokinetics and Metabolic Fate of (±)-(1′R*,3R*)-3-Phenyl-1-[(1′,2′,3′,4′-tetrahydro-5′,6′-methylene-dioxy-1′-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in Dogs
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