Table of Contents

Articles

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  Liver-Specific Distribution of Rosuvastatin in Rats: Comparison with Pravastatin and Simvastatin

  Ken-ichi Nezasa, Kazutaka Higaki, Tadahiko Matsumura, Kazuhiro Inazawa, Hiroshi Hasegawa, Masayuki Nakano and Masahiro Koike

  Drug Metabolism and Disposition November 2002, 30 (11) 1158-1163; DOI: https://doi.org/10.1124/dmd.30.11.1158
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  Interaction of Ritonavir on Tissue Distribution of a [¹⁴C]L-Valinamide, a Potent Human Immunodeficiency Virus-1 Protease Inhibitor, in Rats Using Quantitative Whole-Body Autoradiography

  Eric G. Solon, Suresh K. Balani, Gang Luo, Tian J. Yang, Paula J. Haines, Lifei Wang, Tonya Demond, Sharon Diamond, David D. Christ, Liang-Shang Gan and Frank W. Lee

  Drug Metabolism and Disposition November 2002, 30 (11) 1164-1169; DOI: https://doi.org/10.1124/dmd.30.11.1164
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  Pathways of Carbamazepine Bioactivation in Vitro I. Characterization of Human Cytochromes P450 Responsible for the Formation of 2- and 3-Hydroxylated Metabolites

  Robin E. Pearce, Gangadhara R. Vakkalagadda and J. Steven Leeder

  Drug Metabolism and Disposition November 2002, 30 (11) 1170-1179; DOI: https://doi.org/10.1124/dmd.30.11.1170
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  Metabolism of Bisphenol A in Primary Cultured Hepatocytes from Mice, Rats, and Humans

  J. J. Pritchett, R. K. Kuester and I. G. Sipes

  Drug Metabolism and Disposition November 2002, 30 (11) 1180-1185; DOI: https://doi.org/10.1124/dmd.30.11.1180
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  Down-Regulation of Alpha Class GlutathioneS-Transferase by Interleukin-1β in Human Intestinal Epithelial Cells (Caco-2) in Culture

  Laura Romero, Marnie A. Higgins, James Gilmore, Kim Boudreau, Ann Maslen, Heather J. Barker and Gordon M. Kirby

  Drug Metabolism and Disposition November 2002, 30 (11) 1186-1193; DOI: https://doi.org/10.1124/dmd.30.11.1186
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  Activation of CYP2C9-Mediated Metabolism by a Series of Dapsone Analogs: Kinetics and Structural Requirements

  J. Matthew Hutzler, Dhanashri Kolwankar, Matthew A. Hummel and Timothy S. Tracy

  Drug Metabolism and Disposition November 2002, 30 (11) 1194-1200; DOI: https://doi.org/10.1124/dmd.30.11.1194
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  Effects of G169R and P34S Substitutions Produced by Mutations ofCYP2D6*14 on the Functional Properties of CYP2D6 Expressed in V79 Cells

  Tomoko Shiraishi, Masakiyo Hosokawa, Kaoru Kobayashi, Hitoshi Tainaka, Yoshiyuki Yamaura, Miwo Taguchi and Kan Chiba

  Drug Metabolism and Disposition November 2002, 30 (11) 1201-1205; DOI: https://doi.org/10.1124/dmd.30.11.1201
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  In Vivo and in Vitro Induction of Cytochrome P450 Enzymes in Beagle Dogs

  Richard A. Graham, April Downey, Dan Mudra, Linda Krueger, Kathy Carroll, Christopher Chengelis, Ajay Madan and Andrew Parkinson

  Drug Metabolism and Disposition November 2002, 30 (11) 1206-1213; DOI: https://doi.org/10.1124/dmd.30.11.1206
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  Mechanism of the Reduced Elimination Clearance of Benzylpenicillin from Cerebrospinal Fluid in Rats with Intracisternal Administration of Lipopolysaccharide

  Hee Han, Sang-Geon Kim, Myung-Gull Lee, Chang-Koo Shim and Suk-Jae Chung

  Drug Metabolism and Disposition November 2002, 30 (11) 1214-1220; DOI: https://doi.org/10.1124/dmd.30.11.1214
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  Metabolism of Capecitabine, an Oral Fluorouracil Prodrug:¹⁹F NMR Studies in Animal Models and Human Urine

  Franck Desmoulin, Véronique Gilard, Myriam Malet-Martino and Robert Martino

  Drug Metabolism and Disposition November 2002, 30 (11) 1221-1229; DOI: https://doi.org/10.1124/dmd.30.11.1221
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  Fenbendazole Pharmacokinetics, Metabolism, and Potentiation in Horses

  Q. A. McKellar, C. Gokbulut, K. Muzandu and H. Benchaoui

  Drug Metabolism and Disposition November 2002, 30 (11) 1230-1239; DOI: https://doi.org/10.1124/dmd.30.11.1230
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  Involvement of CYP2J2 on the Intestinal First-Pass Metabolism of Antihistamine Drug, Astemizole

  Shigeki Matsumoto, Tomoe Hirama, Tsutomu Matsubara, Kiyoshi Nagata and Yasushi Yamazoe

  Drug Metabolism and Disposition November 2002, 30 (11) 1240-1245; DOI: https://doi.org/10.1124/dmd.30.11.1240
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  Contribution of Presystemic Hepatic Extraction to the Low Oral Bioavailability of Green Tea Catechins in Rats

  Yan Cai, Nathan D. Anavy and H-H. Sherry Chow

  Drug Metabolism and Disposition November 2002, 30 (11) 1246-1249; DOI: https://doi.org/10.1124/dmd.30.11.1246
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  Involvement of Multiple UDP-glucuronosyltransferase 1A Isoforms in Glucuronidation of 5-(4′-hydroxyphenyl)-5-phenylhydantoin in Human Liver Microsomes

  Miki Nakajima, Nozomi Sakata, Noriko Ohashi, Toshiyuki Kume and Tsuyoshi Yokoi

  Drug Metabolism and Disposition November 2002, 30 (11) 1250-1256; DOI: https://doi.org/10.1124/dmd.30.11.1250
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  Stereoselective Conjugation of Oxazepam by Human UDP-Glucuronosyltransferases (UGTs): S-Oxazepam Is Glucuronidated by UGT2B15, While R-Oxazepam Is Glucuronidated by UGT2B7 and UGT1A9

  Michael H. Court, Su X. Duan, Chantal Guillemette, Kim Journault, Soundararajan Krishnaswamy, Lisa L. von Moltke and David J. Greenblatt

  Drug Metabolism and Disposition November 2002, 30 (11) 1257-1265; DOI: https://doi.org/10.1124/dmd.30.11.1257
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  Differential Modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1)-Catalyzed Estradiol-3-glucuronidation by the Addition of UGT1A1 Substrates and Other Compounds to Human Liver Microsomes

  J. Andrew Williams, Barbara J. Ring, Varon E. Cantrell, Kristina Campanale, David R. Jones, Stephen D. Hall and Steven A. Wrighton

  Drug Metabolism and Disposition November 2002, 30 (11) 1266-1273; DOI: https://doi.org/10.1124/dmd.30.11.1266
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  Biotransformation of Mirtazapine by Cunninghamella Elegans

  Joanna D. Moody, James P. Freeman, Peter P. Fu and Carl E. Cerniglia

  Drug Metabolism and Disposition November 2002, 30 (11) 1274-1279; DOI: https://doi.org/10.1124/dmd.30.11.1274
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  Effects of Fibrates on Metabolism of Statins in Human Hepatocytes

  Thomayant Prueksaritanont, Cuyue Tang, Yue Qiu, Lillian Mu, Raju Subramanian and Jiunn H. Lin

  Drug Metabolism and Disposition November 2002, 30 (11) 1280-1287; DOI: https://doi.org/10.1124/dmd.30.11.1280
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  Structure and Stereochemistry of the Active Metabolite of Clopidogrel

  Jean-Marie Pereillo, Mohamed Maftouh, Alain Andrieu, Marie-Francoise Uzabiaga, Olivier Fedeli, Pierre Savi, Marc Pascal, Jean-Marc Herbert, Jean-Pierre Maffrand and Claudine Picard

  Drug Metabolism and Disposition November 2002, 30 (11) 1288-1295; DOI: https://doi.org/10.1124/dmd.30.11.1288