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Research ArticleArticle

Stereoselective Conjugation of Oxazepam by Human UDP-Glucuronosyltransferases (UGTs): S-Oxazepam Is Glucuronidated by UGT2B15, While R-Oxazepam Is Glucuronidated by UGT2B7 and UGT1A9

Michael H. Court, Su X. Duan, Chantal Guillemette, Kim Journault, Soundararajan Krishnaswamy, Lisa L. von Moltke and David J. Greenblatt
Drug Metabolism and Disposition November 2002, 30 (11) 1257-1265; DOI: https://doi.org/10.1124/dmd.30.11.1257

Article Information

vol. 30 no. 11 1257-1265
DOI 
https://doi.org/10.1124/dmd.30.11.1257
PubMed 
12386133
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 4, 2002
  • Accepted August 14, 2002
  • Published online November 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Michael H. Court1,
  2. Su X. Duan1,
  3. Chantal Guillemette3,
  4. Kim Journault3,
  5. Soundararajan Krishnaswamy1,
  6. Lisa L. von Moltke2 and
  7. David J. Greenblatt2
  1. 1Comparative and Molecular Pharmacogenetics Laboratory (M.H.C., S.X.D., S.K.) and 2Clinical Pharmacology Laboratory (L.L.v.M., D.J.G.), Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts; and 3Pharmacogenetics Laboratory, Centre Hospitalier de l'Université Laval Research Center, University of Laval, Faculty of Pharmacy, Quebec, Canada (C.G., K.J.)
  1. Michael H. Court, Comparative and Molecular Pharmacogenetics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University, 136 Harrison Avenue, Boston, MA 02111. E-mail: michael.court{at}tufts.edu
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Research ArticleArticle

Stereoselective Conjugation of Oxazepam by Human UDP-Glucuronosyltransferases (UGTs): S-Oxazepam Is Glucuronidated by UGT2B15, While R-Oxazepam Is Glucuronidated by UGT2B7 and UGT1A9

Michael H. Court, Su X. Duan, Chantal Guillemette, Kim Journault, Soundararajan Krishnaswamy, Lisa L. von Moltke and David J. Greenblatt
Drug Metabolism and Disposition November 1, 2002, 30 (11) 1257-1265; DOI: https://doi.org/10.1124/dmd.30.11.1257
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