Table of Contents

Articles

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  Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions

  Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang

  Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311
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  Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes

  G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers

  Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320
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  Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450s): Major Differences in Selective Enantiomer Formation by Various P450 Isoforms

  Yiding Hu and David Kupfer

  Drug Metabolism and Disposition December 2002, 30 (12) 1329-1336; DOI: https://doi.org/10.1124/dmd.30.12.1329
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  Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine

  B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine

  Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337
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  Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5

  Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang

  Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344
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  Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes

  Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen

  Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352
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  Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and ¹H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats

  John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan

  Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357
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  Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1.

  Gladys R. Rios and Thomas R. Tephly

  Drug Metabolism and Disposition December 2002, 30 (12) 1364-1367; DOI: https://doi.org/10.1124/dmd.30.12.1364
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  Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway

  Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson

  Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368
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  Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes

  Larry C. Wienkers and Michael A. Wynalda

  Drug Metabolism and Disposition December 2002, 30 (12) 1372-1377; DOI: https://doi.org/10.1124/dmd.30.12.1372
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  Kinetic Study of the Reaction of Cisplatin with Thiols

  James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid

  Drug Metabolism and Disposition December 2002, 30 (12) 1378-1384; DOI: https://doi.org/10.1124/dmd.30.12.1378
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  Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5′-Flanking Region of theCYP2C11 Gene

  Anahita Bhathena, Chunja Lee and David S. Riddick

  Drug Metabolism and Disposition December 2002, 30 (12) 1385-1392; DOI: https://doi.org/10.1124/dmd.30.12.1385
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  Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats

  Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama

  Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393
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  Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes

  Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines

  Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400
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  Functional Properties of a Rainbow Trout CYP3A27 Expressed by Recombinant Baculovirus in Insect Cells

  Su-Jun Lee and Donald R. Buhler

  Drug Metabolism and Disposition December 2002, 30 (12) 1406-1412; DOI: https://doi.org/10.1124/dmd.30.12.1406
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  Effects of Ethanol Dose and Ethanol Withdrawal on Rat Liver Mitochondrial Glutathione: Implication of Potentiated Acetaminophen Toxicity in Alcoholics

  Ping Zhao and John T. Slattery

  Drug Metabolism and Disposition December 2002, 30 (12) 1413-1417; DOI: https://doi.org/10.1124/dmd.30.12.1413
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  Toxicokinetics and Metabolism ofN-[¹⁴C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process

  Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari

  Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418
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  Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys

  Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith

  Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425
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  Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)

  Patricia E. Schroeder, Jeffrey N. Davidson and Brian B. Hasinoff

  Drug Metabolism and Disposition December 2002, 30 (12) 1431-1435; DOI: https://doi.org/10.1124/dmd.30.12.1431
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  Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat

  Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto

  Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436
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  Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors

  Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt

  Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441
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  Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes

  Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng

  Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446
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  Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration

  Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators

  Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455
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  Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10

  Yuichiro Watanabe, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition December 2002, 30 (12) 1462-1469; DOI: https://doi.org/10.1124/dmd.30.12.1462
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  Comparative Pharmacokinetic and Disposition Studies of [1-¹⁴C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats

  Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes

  Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470
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  Microsomal N-Glucuronidation of Nicotine and Cotinine: Human Hepatic Interindividual, Human Intertissue, and Interspecies Hepatic Variation

  Omar Ghosheh and Edward M. Hawes

  Drug Metabolism and Disposition December 2002, 30 (12) 1478-1483; DOI: https://doi.org/10.1124/dmd.30.12.1478
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  Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes

  Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi

  Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484
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  Pharmacokinetics of Midazolam and 1′-Hydroxymidazolam in Chinese with Different CYP3A5 Genotypes

  Pei-Shan Shih and Jin-Ding Huang

  Drug Metabolism and Disposition December 2002, 30 (12) 1491-1496; DOI: https://doi.org/10.1124/dmd.30.12.1491
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  The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

  Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley

  Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497
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  Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities

  Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi

  Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504
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  Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach

  Aleksandra Galetin, Stephen E. Clarke and J. Brian Houston

  Drug Metabolism and Disposition December 2002, 30 (12) 1512-1522; DOI: https://doi.org/10.1124/dmd.30.12.1512
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  Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats

  Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun

  Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523