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Drug Metabolism & Disposition

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Table of Contents

December 01, 2002; Volume 30,Issue 12

Short Communication

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    Deacylation of N-Arylformamides andN-Arylacetamides by Formamidase in Rat Liver
    Osamu Ueda, Shigeyuki Kitamura and Shigeru Ohta
    Drug Metabolism and Disposition December 2002, 30 (12) 1297-1299; DOI: https://doi.org/10.1124/dmd.30.12.1297

MINIREVIEW

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    RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
    Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
    Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300

Articles

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    Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
    Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
    Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311
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    Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
    G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
    Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320
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    Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450s): Major Differences in Selective Enantiomer Formation by Various P450 Isoforms
    Yiding Hu and David Kupfer
    Drug Metabolism and Disposition December 2002, 30 (12) 1329-1336; DOI: https://doi.org/10.1124/dmd.30.12.1329
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    Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
    B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
    Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337
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    Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
    Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
    Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344
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    Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
    Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
    Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352
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    Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
    John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
    Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357
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    Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1.
    Gladys R. Rios and Thomas R. Tephly
    Drug Metabolism and Disposition December 2002, 30 (12) 1364-1367; DOI: https://doi.org/10.1124/dmd.30.12.1364
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    Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
    Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
    Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368
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    Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes
    Larry C. Wienkers and Michael A. Wynalda
    Drug Metabolism and Disposition December 2002, 30 (12) 1372-1377; DOI: https://doi.org/10.1124/dmd.30.12.1372
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    Kinetic Study of the Reaction of Cisplatin with Thiols
    James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid
    Drug Metabolism and Disposition December 2002, 30 (12) 1378-1384; DOI: https://doi.org/10.1124/dmd.30.12.1378
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    Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5′-Flanking Region of theCYP2C11 Gene
    Anahita Bhathena, Chunja Lee and David S. Riddick
    Drug Metabolism and Disposition December 2002, 30 (12) 1385-1392; DOI: https://doi.org/10.1124/dmd.30.12.1385
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    Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
    Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
    Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393
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    Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
    Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
    Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400
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    Functional Properties of a Rainbow Trout CYP3A27 Expressed by Recombinant Baculovirus in Insect Cells
    Su-Jun Lee and Donald R. Buhler
    Drug Metabolism and Disposition December 2002, 30 (12) 1406-1412; DOI: https://doi.org/10.1124/dmd.30.12.1406
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    Effects of Ethanol Dose and Ethanol Withdrawal on Rat Liver Mitochondrial Glutathione: Implication of Potentiated Acetaminophen Toxicity in Alcoholics
    Ping Zhao and John T. Slattery
    Drug Metabolism and Disposition December 2002, 30 (12) 1413-1417; DOI: https://doi.org/10.1124/dmd.30.12.1413
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    Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
    Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
    Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418
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    Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
    Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
    Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425
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    Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)
    Patricia E. Schroeder, Jeffrey N. Davidson and Brian B. Hasinoff
    Drug Metabolism and Disposition December 2002, 30 (12) 1431-1435; DOI: https://doi.org/10.1124/dmd.30.12.1431
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    Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat
    Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
    Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436
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    Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
    Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
    Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441
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    Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
    Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
    Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446
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    Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
    Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
    Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455
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    Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10
    Yuichiro Watanabe, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2002, 30 (12) 1462-1469; DOI: https://doi.org/10.1124/dmd.30.12.1462
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    Comparative Pharmacokinetic and Disposition Studies of [1-14C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
    Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes
    Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470
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    Microsomal N-Glucuronidation of Nicotine and Cotinine: Human Hepatic Interindividual, Human Intertissue, and Interspecies Hepatic Variation
    Omar Ghosheh and Edward M. Hawes
    Drug Metabolism and Disposition December 2002, 30 (12) 1478-1483; DOI: https://doi.org/10.1124/dmd.30.12.1478
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    Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes
    Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484
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    Pharmacokinetics of Midazolam and 1′-Hydroxymidazolam in Chinese with Different CYP3A5 Genotypes
    Pei-Shan Shih and Jin-Ding Huang
    Drug Metabolism and Disposition December 2002, 30 (12) 1491-1496; DOI: https://doi.org/10.1124/dmd.30.12.1491
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    The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
    Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
    Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497
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    Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
    Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
    Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504
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    Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
    Aleksandra Galetin, Stephen E. Clarke and J. Brian Houston
    Drug Metabolism and Disposition December 2002, 30 (12) 1512-1522; DOI: https://doi.org/10.1124/dmd.30.12.1512
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    Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
    Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun
    Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523
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Drug Metabolism and Disposition: 30 (12)
Drug Metabolism and Disposition
Vol. 30, Issue 12
1 Dec 2002
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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