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Index by author

December 01, 2002; Volume 30,Issue 12

A

  1. Austin, Rupert P.

    1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
      Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
      Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497

  2. Awasthi, Sanjay

    1. RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
      Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
      Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300

  3. Awasthi, Yogesh C.

    1. RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
      Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
      Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300

B

  1. Backman, Janne T.

    1. Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
      Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
      Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352

  2. Bailey, Nigel J.C.

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  3. Barton, Patrick

    1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
      Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
      Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497

  4. Berry, Loren M.

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

  5. Beydon, Dominique

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

  6. Bhathena, Anahita

    1. Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5′-Flanking Region of theCYP2C11 Gene
      Anahita Bhathena, Chunja Lee and David S. Riddick
      Drug Metabolism and Disposition December 2002, 30 (12) 1385-1392; DOI: https://doi.org/10.1124/dmd.30.12.1385

  7. Blaschke, Terrence F.

    1. Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
      Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
      Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455

  8. Bonner, Heather S.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  9. Borgeaud, Nathan

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  10. Boudry, Isabelle

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

  11. Buhler, Donald R.

    1. Functional Properties of a Rainbow Trout CYP3A27 Expressed by Recombinant Baculovirus in Insect Cells
      Su-Jun Lee and Donald R. Buhler
      Drug Metabolism and Disposition December 2002, 30 (12) 1406-1412; DOI: https://doi.org/10.1124/dmd.30.12.1406

  12. Burton, Earl G.

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

C

  1. Cai, Hongbo

    1. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
      Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
      Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400

  2. Carter, K. M.

    1. Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
      B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
      Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337

  3. Chen, Chun-Lin

    1. Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
      Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun
      Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523

  4. Cheng, K.-C.

    1. Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
      Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
      Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446

  5. Clarke, Stephen E.

    1. Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
      Aleksandra Galetin, Stephen E. Clarke and J. Brian Houston
      Drug Metabolism and Disposition December 2002, 30 (12) 1512-1522; DOI: https://doi.org/10.1124/dmd.30.12.1512

  6. Cockroft, Scott L.

    1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
      Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
      Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497

  7. Connelly, John C.

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  8. Connor, Susan C.

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  9. Cook, Chyung S.

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

  10. Cook, James M.

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

  11. Cossec, Benoit

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

  12. Cui, Xiaoming

    1. Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
      Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
      Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446

D

  1. Dabrowiak, James C.

    1. Kinetic Study of the Reaction of Cisplatin with Thiols
      James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid
      Drug Metabolism and Disposition December 2002, 30 (12) 1378-1384; DOI: https://doi.org/10.1124/dmd.30.12.1378

  2. Dahn, Michael S.

    1. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
      Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
      Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400

  3. Davidson, Jeffrey N.

    1. Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)
      Patricia E. Schroeder, Jeffrey N. Davidson and Brian B. Hasinoff
      Drug Metabolism and Disposition December 2002, 30 (12) 1431-1435; DOI: https://doi.org/10.1124/dmd.30.12.1431

  4. DeRemer, Susan J.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  5. Dou, Chunzhi

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

E

  1. Elaut, G.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  2. Ensminger, William D.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  3. Ericsson, Örjan

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

F

  1. Fabry, Jean-Paul

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

  2. Ferrari, Elisabeth

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

  3. Flexner, Charles

    1. Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
      Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
      Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455

  4. Fuse, Eiichi

    1. Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
      Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
      Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504

G

  1. Galetin, Aleksandra

    1. Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
      Aleksandra Galetin, Stephen E. Clarke and J. Brian Houston
      Drug Metabolism and Disposition December 2002, 30 (12) 1512-1522; DOI: https://doi.org/10.1124/dmd.30.12.1512

  2. Gavaghan, Claire L.

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  3. Ghosheh, Omar

    1. Microsomal N-Glucuronidation of Nicotine and Cotinine: Human Hepatic Interindividual, Human Intertissue, and Interspecies Hepatic Variation
      Omar Ghosheh and Edward M. Hawes
      Drug Metabolism and Disposition December 2002, 30 (12) 1478-1483; DOI: https://doi.org/10.1124/dmd.30.12.1478

  4. Gibbs, Megan A.

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  5. Goodisman, Jerry

    1. Kinetic Study of the Reaction of Cisplatin with Thiols
      James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid
      Drug Metabolism and Disposition December 2002, 30 (12) 1378-1384; DOI: https://doi.org/10.1124/dmd.30.12.1378

  6. Granda, Brian W.

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  7. Greenblatt, David J.

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  8. Gustafsson, Lars L.

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

H

  1. Halladay, Jason S.

    1. Comparative Pharmacokinetic and Disposition Studies of [1-14C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
      Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes
      Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470

  2. Harmatz, Jerold S.

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  3. Hasegawa, Hiroshi

    1. Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat
      Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
      Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436

  4. Hashimoto, Takao

    1. Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat
      Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
      Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436

  5. Hasinoff, Brian B.

    1. Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)
      Patricia E. Schroeder, Jeffrey N. Davidson and Brian B. Hasinoff
      Drug Metabolism and Disposition December 2002, 30 (12) 1431-1435; DOI: https://doi.org/10.1124/dmd.30.12.1431

  6. Hawes, Edward M.

    1. Microsomal N-Glucuronidation of Nicotine and Cotinine: Human Hepatic Interindividual, Human Intertissue, and Interspecies Hepatic Variation
      Omar Ghosheh and Edward M. Hawes
      Drug Metabolism and Disposition December 2002, 30 (12) 1478-1483; DOI: https://doi.org/10.1124/dmd.30.12.1478

  7. Holmes, Elaine

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  8. Houston, J. Brian

    1. Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
      Aleksandra Galetin, Stephen E. Clarke and J. Brian Houston
      Drug Metabolism and Disposition December 2002, 30 (12) 1512-1522; DOI: https://doi.org/10.1124/dmd.30.12.1512

  9. Hribar, Jeremy D.

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

  10. Hu, Yiding

    1. Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450s): Major Differences in Selective Enantiomer Formation by Various P450 Isoforms
      Yiding Hu and David Kupfer
      Drug Metabolism and Disposition December 2002, 30 (12) 1329-1336; DOI: https://doi.org/10.1124/dmd.30.12.1329

  11. Huang, Jin-Ding

    1. Pharmacokinetics of Midazolam and 1′-Hydroxymidazolam in Chinese with Different CYP3A5 Genotypes
      Pei-Shan Shih and Jin-Ding Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1491-1496; DOI: https://doi.org/10.1124/dmd.30.12.1491

  12. Huang, Shiew-Mei

    1. Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
      Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311

I

  1. Inano, Keiko

    1. Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
      Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
      Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504

  2. Itose, Minoru

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

K

  1. Kajita, Jiro

    1. Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
      Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
      Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504

  2. Kato, Yukio

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

  3. Kellogg, G. E.

    1. Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
      B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
      Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337

  4. Kim, David H.

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

  5. Kitamura, Shigeyuki

    1. Deacylation of N-Arylformamides andN-Arylacetamides by Formamidase in Rat Liver
      Osamu Ueda, Shigeyuki Kitamura and Shigeru Ohta
      Drug Metabolism and Disposition December 2002, 30 (12) 1297-1299; DOI: https://doi.org/10.1124/dmd.30.12.1297

  6. Knol, James A.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  7. Kobayashi, Hiroyuki

    1. Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
      Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
      Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504

  8. Kocarek, Thomas A.

    1. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
      Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
      Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400

  9. Kupfer, David

    1. Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450s): Major Differences in Selective Enantiomer Formation by Various P450 Isoforms
      Yiding Hu and David Kupfer
      Drug Metabolism and Disposition December 2002, 30 (12) 1329-1336; DOI: https://doi.org/10.1124/dmd.30.12.1329

  10. Kuwabara, Takashi

    1. Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
      Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara and Hiroyuki Kobayashi
      Drug Metabolism and Disposition December 2002, 30 (12) 1504-1511; DOI: https://doi.org/10.1124/dmd.30.12.1504

  11. Kwon, Jun-Tack

    1. Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes
      Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484

L

  1. Lau, Yau Yi

    1. Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
      Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
      Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446

  2. Laus, G.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  3. Lee, Chunja

    1. Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5′-Flanking Region of theCYP2C11 Gene
      Anahita Bhathena, Chunja Lee and David S. Riddick
      Drug Metabolism and Disposition December 2002, 30 (12) 1385-1392; DOI: https://doi.org/10.1124/dmd.30.12.1385

  4. Lee, Su-Jun

    1. Functional Properties of a Rainbow Trout CYP3A27 Expressed by Recombinant Baculovirus in Insect Cells
      Su-Jun Lee and Donald R. Buhler
      Drug Metabolism and Disposition December 2002, 30 (12) 1406-1412; DOI: https://doi.org/10.1124/dmd.30.12.1406

  5. Levi, Micha

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  6. Lu, Jian-Feng

    1. Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
      Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
      Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455

  7. Lunte, Susan M.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

M

  1. Mackerer, Carl R.

    1. Comparative Pharmacokinetic and Disposition Studies of [1-14C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
      Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes
      Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470

  2. Madani, Soraya

    1. Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
      Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311

  3. Matsukawa, Takehisa

    1. Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat
      Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
      Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436

  4. Mercer-Haines, Nancy A.

    1. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
      Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
      Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400

  5. Mirghani, Rajaa A.

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

  6. Miyamoto, Gohachiro

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

  7. Monte, Soria

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

N

  1. Nakajima, Miki

    1. Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10
      Yuichiro Watanabe, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1462-1469; DOI: https://doi.org/10.1124/dmd.30.12.1462
    2. Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes
      Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484

  2. Neuvonen, Mikko

    1. Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
      Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
      Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352

  3. Neuvonen, Pertti J.

    1. Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
      Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
      Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352

  4. Nicholson, Jeremy K.

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

O

  1. Obach, R. Scott

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  2. Ohta, Shigeru

    1. Deacylation of N-Arylformamides andN-Arylacetamides by Formamidase in Rat Liver
      Osamu Ueda, Shigeyuki Kitamura and Shigeru Ohta
      Drug Metabolism and Disposition December 2002, 30 (12) 1297-1299; DOI: https://doi.org/10.1124/dmd.30.12.1297

P

  1. Papeleu, P.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  2. Payan, Jean-Paul

    1. Toxicokinetics and Metabolism ofN-[14C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
      Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec and Elisabeth Ferrari
      Drug Metabolism and Disposition December 2002, 30 (12) 1418-1424; DOI: https://doi.org/10.1124/dmd.30.12.1418

R

  1. Rege, B.

    1. Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
      B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
      Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337

  2. Reynolds, Kellie

    1. Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
      Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311

  3. Riddick, David S.

    1. Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5′-Flanking Region of theCYP2C11 Gene
      Anahita Bhathena, Chunja Lee and David S. Riddick
      Drug Metabolism and Disposition December 2002, 30 (12) 1385-1392; DOI: https://doi.org/10.1124/dmd.30.12.1385

  4. Riley, Robert J.

    1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
      Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
      Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497

  5. Rios, Gladys R.

    1. Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1.
      Gladys R. Rios and Thomas R. Tephly
      Drug Metabolism and Disposition December 2002, 30 (12) 1364-1367; DOI: https://doi.org/10.1124/dmd.30.12.1364

  6. Rogiers, V.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  7. Rosenkranz, Susan L.

    1. Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
      Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
      Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455

S

  1. Sapidou, Elpida

    1. Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
      Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
      Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446

  2. Sarkar, M. A.

    1. Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
      B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
      Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337

  3. Sasabe, Hiroyuki

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

  4. Schroeder, Patricia E.

    1. Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)
      Patricia E. Schroeder, Jeffrey N. Davidson and Brian B. Hasinoff
      Drug Metabolism and Disposition December 2002, 30 (12) 1431-1435; DOI: https://doi.org/10.1124/dmd.30.12.1431

  5. Sharma, Rajendra

    1. RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
      Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
      Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300

  6. Shaw, Leslie M.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  7. Sheiner, Lewis B.

    1. Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
      Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, Lewis B. Sheiner and AIDS Clinical Trials Group Protocol 378 Investigators
      Drug Metabolism and Disposition December 2002, 30 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.30.12.1455

  8. Shih, Pei-Shan

    1. Pharmacokinetics of Midazolam and 1′-Hydroxymidazolam in Chinese with Different CYP3A5 Genotypes
      Pei-Shan Shih and Jin-Ding Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1491-1496; DOI: https://doi.org/10.1124/dmd.30.12.1491

  9. Shinohara, Yoshihiko

    1. Kinetics of Sequential Metabolism from d-Leucine tol-Leucine via α-Ketoisocaproic Acid in Rat
      Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
      Drug Metabolism and Disposition December 2002, 30 (12) 1436-1440; DOI: https://doi.org/10.1124/dmd.30.12.1436

  10. Singhal, Sharad S.

    1. RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
      Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
      Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300

  11. Sipes, I. Glenn

    1. Comparative Pharmacokinetic and Disposition Studies of [1-14C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
      Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes
      Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470

  12. Slattery, John T.

    1. Effects of Ethanol Dose and Ethanol Withdrawal on Rat Liver Mitochondrial Glutathione: Implication of Potentiated Acetaminophen Toxicity in Alcoholics
      Ping Zhao and John T. Slattery
      Drug Metabolism and Disposition December 2002, 30 (12) 1413-1417; DOI: https://doi.org/10.1124/dmd.30.12.1413

  13. Smith, David E.

    1. Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
      Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw and David E. Smith
      Drug Metabolism and Disposition December 2002, 30 (12) 1425-1430; DOI: https://doi.org/10.1124/dmd.30.12.1425

  14. Soine, W. H.

    1. Irreversible Inhibition of CYP2D6 by (−)-Chloroephedrine, a Possible Impurity in Methamphetamine
      B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg and W. H. Soine
      Drug Metabolism and Disposition December 2002, 30 (12) 1337-1343; DOI: https://doi.org/10.1124/dmd.30.12.1337

  15. Souid, Abdul-Kader

    1. Kinetic Study of the Reaction of Cisplatin with Thiols
      James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid
      Drug Metabolism and Disposition December 2002, 30 (12) 1378-1384; DOI: https://doi.org/10.1124/dmd.30.12.1378

  16. Strom, Stephen C.

    1. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
      Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom and Nancy A. Mercer-Haines
      Drug Metabolism and Disposition December 2002, 30 (12) 1400-1405; DOI: https://doi.org/10.1124/dmd.30.12.1400

  17. Sugiyama, Yuichi

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

  18. Suzuki, Takashi

    1. Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
      Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto and Yuichi Sugiyama
      Drug Metabolism and Disposition December 2002, 30 (12) 1393-1399; DOI: https://doi.org/10.1124/dmd.30.12.1393

T

  1. Tanaka, Eriko

    1. Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes
      Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484

  2. Tephly, Thomas R.

    1. Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1.
      Gladys R. Rios and Thomas R. Tephly
      Drug Metabolism and Disposition December 2002, 30 (12) 1364-1367; DOI: https://doi.org/10.1124/dmd.30.12.1364

  3. Török, G.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  4. Tourwe, D.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  5. Tran, Thanh Huu

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  6. Troke, Jeff

    1. Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and 1H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
      John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson and Claire L. Gavaghan
      Drug Metabolism and Disposition December 2002, 30 (12) 1357-1363; DOI: https://doi.org/10.1124/dmd.30.12.1357

  7. Twerdok, Lorraine E.

    1. Comparative Pharmacokinetic and Disposition Studies of [1-14C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
      Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok and I. Glenn Sipes
      Drug Metabolism and Disposition December 2002, 30 (12) 1470-1477; DOI: https://doi.org/10.1124/dmd.30.12.1470

  8. Tybring, Gunnel

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

U

  1. Uckun, Fatih M.

    1. Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
      Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun
      Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523

  2. Ueda, Osamu

    1. Deacylation of N-Arylformamides andN-Arylacetamides by Formamidase in Rat Liver
      Osamu Ueda, Shigeyuki Kitamura and Shigeru Ohta
      Drug Metabolism and Disposition December 2002, 30 (12) 1297-1299; DOI: https://doi.org/10.1124/dmd.30.12.1297

V

  1. Venkatachalam, T. K.

    1. Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
      Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun
      Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523

  2. Venkatakrishnan, Karthik

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

  3. Vinken, M.

    1. Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
      G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe and V. Rogiers
      Drug Metabolism and Disposition December 2002, 30 (12) 1320-1328; DOI: https://doi.org/10.1124/dmd.30.12.1320

  4. von Moltke, Lisa L.

    1. Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
      Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz and David J. Greenblatt
      Drug Metabolism and Disposition December 2002, 30 (12) 1441-1445; DOI: https://doi.org/10.1124/dmd.30.12.1441

W

  1. Wang, Jun-Sheng

    1. Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
      Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
      Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352

  2. Watanabe, Yuichiro

    1. Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10
      Yuichiro Watanabe, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1462-1469; DOI: https://doi.org/10.1124/dmd.30.12.1462

  3. Wei, Xiao-Xiong

    1. Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
      Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311

  4. Wen, Xia

    1. Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
      Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman and Pertti J. Neuvonen
      Drug Metabolism and Disposition December 2002, 30 (12) 1352-1356; DOI: https://doi.org/10.1124/dmd.30.12.1352

  5. Wenlock, Mark C.

    1. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
      Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock and Robert J. Riley
      Drug Metabolism and Disposition December 2002, 30 (12) 1497-1503; DOI: https://doi.org/10.1124/dmd.30.12.1497

  6. White, Ronald E.

    1. Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
      Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White and K.-C. Cheng
      Drug Metabolism and Disposition December 2002, 30 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.30.12.1446

  7. Wienkers, Larry C.

    1. Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes
      Larry C. Wienkers and Michael A. Wynalda
      Drug Metabolism and Disposition December 2002, 30 (12) 1372-1377; DOI: https://doi.org/10.1124/dmd.30.12.1372

  8. Wynalda, Michael A.

    1. Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes
      Larry C. Wienkers and Michael A. Wynalda
      Drug Metabolism and Disposition December 2002, 30 (12) 1372-1377; DOI: https://doi.org/10.1124/dmd.30.12.1372

Y

  1. Yasar, Ümit

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

  2. Yokoi, Tsuyoshi

    1. Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10
      Yuichiro Watanabe, Miki Nakajima and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1462-1469; DOI: https://doi.org/10.1124/dmd.30.12.1462
    2. Characterization of Nicotine and CotinineN-Glucuronidations in Human Liver Microsomes
      Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon and Tsuyoshi Yokoi
      Drug Metabolism and Disposition December 2002, 30 (12) 1484-1490; DOI: https://doi.org/10.1124/dmd.30.12.1484

  3. Yu, Gengli

    1. Metabolism of Stavudine-5′-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
      Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam and Fatih M. Uckun
      Drug Metabolism and Disposition December 2002, 30 (12) 1523-1531; DOI: https://doi.org/10.1124/dmd.30.12.1523

  4. Yuan, Rae

    1. Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
      Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds and Shiew-Mei Huang
      Drug Metabolism and Disposition December 2002, 30 (12) 1311-1319; DOI: https://doi.org/10.1124/dmd.30.12.1311

Z

  1. Zhang, Liming

    1. Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
      Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar and Liming Zhang
      Drug Metabolism and Disposition December 2002, 30 (12) 1344-1351; DOI: https://doi.org/10.1124/dmd.30.12.1344

  2. Zhao, Ping

    1. Effects of Ethanol Dose and Ethanol Withdrawal on Rat Liver Mitochondrial Glutathione: Implication of Potentiated Acetaminophen Toxicity in Alcoholics
      Ping Zhao and John T. Slattery
      Drug Metabolism and Disposition December 2002, 30 (12) 1413-1417; DOI: https://doi.org/10.1124/dmd.30.12.1413

  3. Zheng, Tao

    1. Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
      Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring and Örjan Ericsson
      Drug Metabolism and Disposition December 2002, 30 (12) 1368-1371; DOI: https://doi.org/10.1124/dmd.30.12.1368

  4. Zimniak, Piotr

    1. RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
      Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak and Yogesh C. Awasthi
      Drug Metabolism and Disposition December 2002, 30 (12) 1300-1310; DOI: https://doi.org/10.1124/dmd.30.12.1300
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