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Drug Metabolism & Disposition

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Table of Contents

February 01, 2002; Volume 30,Issue 2

Short Communication

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    Oxidation of the Flavonoids Galangin and Kaempferide by Human Liver Microsomes and CYP1A1, CYP1A2, and CYP2C9
    Yoko Otake and Thomas Walle
    Drug Metabolism and Disposition February 2002, 30 (2) 103-105; DOI: https://doi.org/10.1124/dmd.30.2.103

Articles

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    The in Vivo Human Metabolism of Tibolone
    R. M. E. Vos, S. F. M. Krebbers, C. H. J. Verhoeven and L. P. C. Delbressine
    Drug Metabolism and Disposition February 2002, 30 (2) 106-112; DOI: https://doi.org/10.1124/dmd.30.2.106
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    Reductive Metabolism ofp,p′-DDT ando,p′-DDT by Rat Liver Cytochrome P450
    Shigeyuki Kitamura, Yuri Shimizu, Yuko Shiraga, Mayumi Yoshida, Kazumi Sugihara and Shigeru Ohta
    Drug Metabolism and Disposition February 2002, 30 (2) 113-118; DOI: https://doi.org/10.1124/dmd.30.2.113
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    Cloning, Sequencing, and Tissue-Dependent Expression of Flavin-Containing Monooxygenase (FMO) 1 and FMO3 in the Dog
    Virginie Lattard, Christiane Longin-Sauvageon, Joel Lachuer, Paul Delatour and Etienne Benoit
    Drug Metabolism and Disposition February 2002, 30 (2) 119-128; DOI: https://doi.org/10.1124/dmd.30.2.119
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    UDP Glucuronosyltransferase mRNA Levels in Human Liver Disease
    Mario Congiu, Maurice L. Mashford, John L. Slavin and Paul V. Desmond
    Drug Metabolism and Disposition February 2002, 30 (2) 129-134; DOI: https://doi.org/10.1124/dmd.30.2.129
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    The Effect of Bergamottin on Diazepam Plasma Levels and P450 Enzymes in Beagle Dogs
    Jasminder Sahi, Eric L. Reyner, Jonathan N. Bauman, Kristina Gueneva-Boucheva, James E. Burleigh and V. Hayden Thomas
    Drug Metabolism and Disposition February 2002, 30 (2) 135-140; DOI: https://doi.org/10.1124/dmd.30.2.135
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    Middle-Age Alterations in the Sexually Dimorphic Plasma Growth Hormone Profiles: Involvement of Growth Hormone-Releasing Factor and Effects on Cytochrome P450 Expression
    Ravindra N. Dhir, Wojciech Dworakowski and Bernard H. Shapiro
    Drug Metabolism and Disposition February 2002, 30 (2) 141-147; DOI: https://doi.org/10.1124/dmd.30.2.141
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    Biotransformation of l-CysteineS-Conjugates andN-Acetyl-l-CysteineS-Conjugates of the Sevoflurane Degradation Product Fluoromethyl-2,2-Difluoro-1-(trifluoromethyl)vinyl Ether (Compound A) in Human Kidney in Vitro: Interindividual Variability inN-Acetylation, N-Deacetylation, and β-Lyase-Catalyzed Metabolism
    T. Gul Altuntas and Evan D. Kharasch
    Drug Metabolism and Disposition February 2002, 30 (2) 148-154; DOI: https://doi.org/10.1124/dmd.30.2.148
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    Formation of a Novel Quinone Epoxide Metabolite of Troglitazone with Cytotoxic to HepG2 Cells
    Yui Yamamoto, Hiroshi Yamazaki, Tomoko Ikeda, Terumi Watanabe, Haruo Iwabuchi, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition February 2002, 30 (2) 155-160; DOI: https://doi.org/10.1124/dmd.30.2.155
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    Conjugation of Desmethylnaproxen in the Rat—A Novel Acyl Glucuronide-Sulfate Diconjugate as a Major Biliary Metabolite
    R. Jaggi, R. S. Addison, A. R. King, B. D. Suthers and R. G. Dickinson
    Drug Metabolism and Disposition February 2002, 30 (2) 161-166; DOI: https://doi.org/10.1124/dmd.30.2.161
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    Pharmacokinetics and Biliary Excretion of Osaterone Acetate, a New Steroidal Antiandrogen, in Dogs
    Kouichi Minato, Naoyuki Koizumi, Seijirou Honma, Kunio Tsukamoto and Satoshi Iwamura
    Drug Metabolism and Disposition February 2002, 30 (2) 167-172; DOI: https://doi.org/10.1124/dmd.30.2.167
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    Brain Pharmacokinetics of a Nonpeptidic Corticotropin-Releasing Factor Receptor Antagonist
    Caroline Keller, Armin Bruelisauer, Michel Lemaire and Albert Enz
    Drug Metabolism and Disposition February 2002, 30 (2) 173-176; DOI: https://doi.org/10.1124/dmd.30.2.173
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    The Influence of l-Glutamine on the Depression of Hepatic Cytochrome P450 Activity in Male Rats Caused by Total Parenteral Nutrition
    Andrew A. Shaw, Stephen D. Hall, Michael R. Franklin and Raymond E. Galinsky
    Drug Metabolism and Disposition February 2002, 30 (2) 177-182; DOI: https://doi.org/10.1124/dmd.30.2.177
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    Kinetics of Cisplatin Binding to Cellular DNA and Modulations by Thiol-Blocking Agents and Thiol Drugs
    Peter D. Sadowitz, Bradley A. Hubbard, James C. Dabrowiak, Jerry Goodisman, Kirk A. Tacka, Mehmet K. Aktas, Mary J. Cunningham, Ronald L. Dubowy and Abdul-Kader Souid
    Drug Metabolism and Disposition February 2002, 30 (2) 183-190; DOI: https://doi.org/10.1124/dmd.30.2.183
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    Investigation of the Mechanism of Enhancement of Central Nervous System Delivery of 2′-β-Fluoro-2′,3′-Dideoxyinosine Via a Blood-Brain Barrier Adenosine Deaminase-Activated Prodrug
    Mark D. Johnson, Jian Chen and Bradley D. Anderson
    Drug Metabolism and Disposition February 2002, 30 (2) 191-198; DOI: https://doi.org/10.1124/dmd.30.2.191
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    Characterization of Catechol Glucuronidation in Rat Liver
    Laurence Antonio, Joël-Paul Grillasca, Jyrki Taskinen, Eivor Elovaara, Brian Burchell, Marie-Helene Piet, Brian Ethell, Mohamed Ouzzine, Sylvie Fournel-Gigleux and Jacques Magdalou
    Drug Metabolism and Disposition February 2002, 30 (2) 199-207; DOI: https://doi.org/10.1124/dmd.30.2.199
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    Retinoic Acids Repress Constitutive Active Receptor-Mediated Induction by 1,4-bis[2-(3,5-Dichloropyridyloxy)]benzene of theCyp2b10 Gene in Mouse Primary Hepatocytes
    Satoru Kakizaki, Sohrab Karami and Masahiko Negishi
    Drug Metabolism and Disposition February 2002, 30 (2) 208-211; DOI: https://doi.org/10.1124/dmd.30.2.208
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    Tissue Distribution and Renal Developmental Changes in Rat Organic Cation Transporter mRNA levels
    A. L. Slitt, N. J. Cherrington, D. P. Hartley, T. M. Leazer and C. D. Klaassen
    Drug Metabolism and Disposition February 2002, 30 (2) 212-219; DOI: https://doi.org/10.1124/dmd.30.2.212
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    Effect of 17β-Estradiol-d-17β-Glucuronide on the Rat Organic Anion Transporting Polypeptide 2-Mediated Transport Differs Depending on Substrates
    Daisuke Sugiyama, Hiroyuki Kusuhara, Yoshihisa Shitara, Takaaki Abe and Yuichi Sugiyama
    Drug Metabolism and Disposition February 2002, 30 (2) 220-223; DOI: https://doi.org/10.1124/dmd.30.2.220
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Drug Metabolism and Disposition: 30 (2)
Drug Metabolism and Disposition
Vol. 30, Issue 2
1 Feb 2002
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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