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Biotransformation of l-CysteineS-Conjugates andN-Acetyl-l-CysteineS-Conjugates of the Sevoflurane Degradation Product Fluoromethyl-2,2-Difluoro-1-(trifluoromethyl)vinyl Ether (Compound A) in Human Kidney in Vitro: Interindividual Variability inN-Acetylation, N-Deacetylation, and β-Lyase-Catalyzed Metabolism

T. Gul Altuntas and Evan D. Kharasch
Drug Metabolism and Disposition February 2002, 30 (2) 148-154; DOI: https://doi.org/10.1124/dmd.30.2.148

Article Information

vol. 30 no. 2 148-154
DOI 
https://doi.org/10.1124/dmd.30.2.148
PubMed 
11792683
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 17, 2001
  • Accepted November 9, 2001
  • Published online February 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. T. Gul Altuntas1 and
  2. Evan D. Kharasch1,2
  1. 1Department of Anesthesiology (T.G.A., E.D.K.) and 2Department of Medicinal Chemistry (E.D.K.), University of Washington, Seattle, Washington
  1. Professor Evan D. Kharasch, Department of Anesthesiology, University of Washington, Box 356540, Seattle, WA 98195. E-mail: kharasch{at}u.washington.edu
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Research ArticleArticle

Biotransformation of l-CysteineS-Conjugates andN-Acetyl-l-CysteineS-Conjugates of the Sevoflurane Degradation Product Fluoromethyl-2,2-Difluoro-1-(trifluoromethyl)vinyl Ether (Compound A) in Human Kidney in Vitro: Interindividual Variability inN-Acetylation, N-Deacetylation, and β-Lyase-Catalyzed Metabolism

T. Gul Altuntas and Evan D. Kharasch
Drug Metabolism and Disposition February 1, 2002, 30 (2) 148-154; DOI: https://doi.org/10.1124/dmd.30.2.148
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