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Research ArticleArticle

Formation of a Novel Quinone Epoxide Metabolite of Troglitazone with Cytotoxic to HepG2 Cells

Yui Yamamoto, Hiroshi Yamazaki, Tomoko Ikeda, Terumi Watanabe, Haruo Iwabuchi, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition February 2002, 30 (2) 155-160; DOI: https://doi.org/10.1124/dmd.30.2.155

Article Information

vol. 30 no. 2 155-160
DOI 
https://doi.org/10.1124/dmd.30.2.155
PubMed 
11792684
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 2, 2001
  • Accepted November 6, 2001
  • Published online February 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yui Yamamoto1,
  2. Hiroshi Yamazaki1,
  3. Tomoko Ikeda2,
  4. Terumi Watanabe2,
  5. Haruo Iwabuchi2,
  6. Miki Nakajima1 and
  7. Tsuyoshi Yokoi1
  1. 1Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (Y.Y., H.Y., M.N., T.Y.); and 2Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Company Limited, Tokyo, Japan (T.I., T.W., H.I.)
  1. Dr. Tsuyoshi Yokoi, Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan. E-mail:tyokoi{at}kenroku.kanazawa-u.ac.jp
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Research ArticleArticle

Formation of a Novel Quinone Epoxide Metabolite of Troglitazone with Cytotoxic to HepG2 Cells

Yui Yamamoto, Hiroshi Yamazaki, Tomoko Ikeda, Terumi Watanabe, Haruo Iwabuchi, Miki Nakajima and Tsuyoshi Yokoi
Drug Metabolism and Disposition February 1, 2002, 30 (2) 155-160; DOI: https://doi.org/10.1124/dmd.30.2.155
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