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Drug Metabolism & Disposition

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Table of Contents

March 01, 2002; Volume 30,Issue 3

Short Communications

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    Structural Characterization of in Vivo Rat Glutathione Adducts and a Hydroxylated Metabolite of Simvastatin Hydroxy Acid
    Raju Subramanian, Xiaojun Fang and Thomayant Prueksaritanont
    Drug Metabolism and Disposition March 2002, 30 (3) 225-230; DOI: https://doi.org/10.1124/dmd.30.3.225
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    Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein Efflux System
    Abba J. Kastin, Melita B. Fasold and James E. Zadina
    Drug Metabolism and Disposition March 2002, 30 (3) 231-234; DOI: https://doi.org/10.1124/dmd.30.3.231

Articles

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    (+)-N-3-Benzyl-Nirvanol and (−)-N-3-Benzyl-Phenobarbital: New Potent and Selective in Vitro Inhibitors of CYP2C19
    Hisashi Suzuki, M. Byron Kneller, Robert L. Haining, William F. Trager and Allan E. Rettie
    Drug Metabolism and Disposition March 2002, 30 (3) 235-239; DOI: https://doi.org/10.1124/dmd.30.3.235
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    Increase in Rat Liver UDP-Glucuronosyltransferase mRNA by Microsomal Enzyme Inducers that Enhance Thyroid Hormone Glucuronidation
    Nichole R. Vansell and Curtis D. Klaassen
    Drug Metabolism and Disposition March 2002, 30 (3) 240-246; DOI: https://doi.org/10.1124/dmd.30.3.240
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    Urinary Naphthalene Mercapturates as Biomarkers of Exposure and Stereoselectivity of Naphthalene Epoxidation
    Gwyn Pakenham, Jozsef Lango, Michael Buonarati, Dexter Morin and Alan Buckpitt
    Drug Metabolism and Disposition March 2002, 30 (3) 247-253; DOI: https://doi.org/10.1124/dmd.30.3.247
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    The Pharmacokinetic Determinants of the Frequency and Pattern of Intravenous Cocaine Self-administration in Rats by Pharmacokinetic Modeling
    Chyan E. Lau and Lei Sun
    Drug Metabolism and Disposition March 2002, 30 (3) 254-261; DOI: https://doi.org/10.1124/dmd.30.3.254
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    Induction of CYP1A1 and CYP1B1 in T-47D Human Breast Cancer Cells by Benzo[a]pyrene Is Diminished by Arsenite
    David C. Spink, Barbara H. Katz, Mirza M. Hussain, Barbara C. Spink, Susan J. Wu, Ning Liu, Ronald Pause and Laurence S. Kaminsky
    Drug Metabolism and Disposition March 2002, 30 (3) 262-269; DOI: https://doi.org/10.1124/dmd.30.3.262
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    Characterization by Liquid Chromatography-Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-Mass Spectrometry of Two Coupled Oxidative-Conjugative Metabolic Pathways for 7-Ethoxycoumarin in Human Liver Microsomes Treated with Alamethicin
    Michael B. Fisher, David Jackson, Andreas Kaerner, Steven A. Wrighton and Anthony G. Borel
    Drug Metabolism and Disposition March 2002, 30 (3) 270-275; DOI: https://doi.org/10.1124/dmd.30.3.270
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    Incorporating Measures of Variability and Uncertainty into the Prediction of in Vivo Hepatic Clearance from in Vitro Data
    Ivan Nestorov, Ivelina Gueorguieva, Hannah M. Jones, Brian Houston and Malcolm Rowland
    Drug Metabolism and Disposition March 2002, 30 (3) 276-282; DOI: https://doi.org/10.1124/dmd.30.3.276
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    Postnatal Expression and Induction by Pregnenolone-16α-Carbonitrile of the Organic Anion-Transporting Polypeptide 2 in Rat Liver
    Grace L. Guo, David R. Johnson and Curtis D. Klaassen
    Drug Metabolism and Disposition March 2002, 30 (3) 283-288; DOI: https://doi.org/10.1124/dmd.30.3.283
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    In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide
    Khawja A. Usmani, Randy L. Rose, Joyce A. Goldstein, Wesley G. Taylor, Alan A. Brimfield and Ernest Hodgson
    Drug Metabolism and Disposition March 2002, 30 (3) 289-294; DOI: https://doi.org/10.1124/dmd.30.3.289
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    N-Glucuronidation of Some 4-Arylalkyl-1H-Imidazoles by Rat, Dog, and Human Liver Microsomes
    Sanna Kaivosaari, Jarmo S. Salonen and Jyrki Taskinen
    Drug Metabolism and Disposition March 2002, 30 (3) 295-300; DOI: https://doi.org/10.1124/dmd.30.3.295
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    Phosphonate O-Deethylation of [4-(4-Bromo-2-Cyano-Phenylcarbamoyl) Benzyl]-Phosphonic Acid Diethyl Ester, a Lipoprotein Lipase-Promoting Agent, Catalyzed by Cytochrome P450 2C8 and 3A4 in Human Liver Microsomes
    Yujiro Morioka, Makiko Otsu, Shinsaku Naito and Teruko Imai
    Drug Metabolism and Disposition March 2002, 30 (3) 301-306; DOI: https://doi.org/10.1124/dmd.30.3.301
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    Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency
    Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans and Jan van Eijkeren
    Drug Metabolism and Disposition March 2002, 30 (3) 307-313; DOI: https://doi.org/10.1124/dmd.30.3.307
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    Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives
    Wenjiang Zhang, Yamini Ramamoorthy, Tansel Kilicarslan, Helma Nolte, Rachel F. Tyndale and Edward M. Sellers
    Drug Metabolism and Disposition March 2002, 30 (3) 314-318; DOI: https://doi.org/10.1124/dmd.30.3.314
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    Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism
    Barbara J. Ring, Jennifer S. Gillespie, James A. Eckstein and Steven A. Wrighton
    Drug Metabolism and Disposition March 2002, 30 (3) 319-323; DOI: https://doi.org/10.1124/dmd.30.3.319
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    Glucuronidation of Acetaminophen Catalyzed by Multiple Rat Phenol UDP-Glucuronosyltransferases
    Fay K. Kessler, Marissa R. Kessler, Diana J. Auyeung and Joseph K. Ritter
    Drug Metabolism and Disposition March 2002, 30 (3) 324-330; DOI: https://doi.org/10.1124/dmd.30.3.324
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    Glutathione and Mercapturic Acid Conjugates of Sulofenur and Their Activity against a Human Colon Cancer Cell Line
    Xiangming Guan, Brianna N. Hoffman, Douglas C. McFarland, Kysa K. Gilkerson, Chandradhar Dwivedi, Angela K. Erickson, Scott Bebensee and Jill Pellegrini
    Drug Metabolism and Disposition March 2002, 30 (3) 331-335; DOI: https://doi.org/10.1124/dmd.30.3.331
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    The Gastroprokinetic and Antiemetic Drug Metoclopramide Is a Substrate and Inhibitor of Cytochrome P450 2D6
    Z. Desta, G. M. Wu, A. M. Morocho and D. A. Flockhart
    Drug Metabolism and Disposition March 2002, 30 (3) 336-343; DOI: https://doi.org/10.1124/dmd.30.3.336
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    Chiral Pharmacokinetics and Inversion of Enantiomers of a New Quinoxaline Topoisomerase IIβ Poison in the Rat
    Hui Zheng, Chun Jiang, Ming H. Chiu, Joseph M. Covey and Kenneth K. Chan
    Drug Metabolism and Disposition March 2002, 30 (3) 344-348; DOI: https://doi.org/10.1124/dmd.30.3.344
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    The Alkaloid Rutaecarpine Is a Selective Inhibitor of Cytochrome P450 1A in Mouse and Human Liver Microsomes
    Yune-Fang Ueng, Woan-Ching Jan, Lie-Chwen Lin, Ta-Liang Chen, F. Peter Guengerich and Chieh-Fu Chen
    Drug Metabolism and Disposition March 2002, 30 (3) 349-353; DOI: https://doi.org/10.1124/dmd.30.3.349
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Drug Metabolism and Disposition: 30 (3)
Drug Metabolism and Disposition
Vol. 30, Issue 3
1 Mar 2002
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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