Table of Contents

Articles

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  (+)-N-3-Benzyl-Nirvanol and (−)-N-3-Benzyl-Phenobarbital: New Potent and Selective in Vitro Inhibitors of CYP2C19

  Hisashi Suzuki, M. Byron Kneller, Robert L. Haining, William F. Trager and Allan E. Rettie

  Drug Metabolism and Disposition March 2002, 30 (3) 235-239; DOI: https://doi.org/10.1124/dmd.30.3.235
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  Increase in Rat Liver UDP-Glucuronosyltransferase mRNA by Microsomal Enzyme Inducers that Enhance Thyroid Hormone Glucuronidation

  Nichole R. Vansell and Curtis D. Klaassen

  Drug Metabolism and Disposition March 2002, 30 (3) 240-246; DOI: https://doi.org/10.1124/dmd.30.3.240
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  Urinary Naphthalene Mercapturates as Biomarkers of Exposure and Stereoselectivity of Naphthalene Epoxidation

  Gwyn Pakenham, Jozsef Lango, Michael Buonarati, Dexter Morin and Alan Buckpitt

  Drug Metabolism and Disposition March 2002, 30 (3) 247-253; DOI: https://doi.org/10.1124/dmd.30.3.247
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  The Pharmacokinetic Determinants of the Frequency and Pattern of Intravenous Cocaine Self-administration in Rats by Pharmacokinetic Modeling

  Chyan E. Lau and Lei Sun

  Drug Metabolism and Disposition March 2002, 30 (3) 254-261; DOI: https://doi.org/10.1124/dmd.30.3.254
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  Induction of CYP1A1 and CYP1B1 in T-47D Human Breast Cancer Cells by Benzo[a]pyrene Is Diminished by Arsenite

  David C. Spink, Barbara H. Katz, Mirza M. Hussain, Barbara C. Spink, Susan J. Wu, Ning Liu, Ronald Pause and Laurence S. Kaminsky

  Drug Metabolism and Disposition March 2002, 30 (3) 262-269; DOI: https://doi.org/10.1124/dmd.30.3.262
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  Characterization by Liquid Chromatography-Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-Mass Spectrometry of Two Coupled Oxidative-Conjugative Metabolic Pathways for 7-Ethoxycoumarin in Human Liver Microsomes Treated with Alamethicin

  Michael B. Fisher, David Jackson, Andreas Kaerner, Steven A. Wrighton and Anthony G. Borel

  Drug Metabolism and Disposition March 2002, 30 (3) 270-275; DOI: https://doi.org/10.1124/dmd.30.3.270
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  Incorporating Measures of Variability and Uncertainty into the Prediction of in Vivo Hepatic Clearance from in Vitro Data

  Ivan Nestorov, Ivelina Gueorguieva, Hannah M. Jones, Brian Houston and Malcolm Rowland

  Drug Metabolism and Disposition March 2002, 30 (3) 276-282; DOI: https://doi.org/10.1124/dmd.30.3.276
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  Postnatal Expression and Induction by Pregnenolone-16α-Carbonitrile of the Organic Anion-Transporting Polypeptide 2 in Rat Liver

  Grace L. Guo, David R. Johnson and Curtis D. Klaassen

  Drug Metabolism and Disposition March 2002, 30 (3) 283-288; DOI: https://doi.org/10.1124/dmd.30.3.283
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  In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide

  Khawja A. Usmani, Randy L. Rose, Joyce A. Goldstein, Wesley G. Taylor, Alan A. Brimfield and Ernest Hodgson

  Drug Metabolism and Disposition March 2002, 30 (3) 289-294; DOI: https://doi.org/10.1124/dmd.30.3.289
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  N-Glucuronidation of Some 4-Arylalkyl-1H-Imidazoles by Rat, Dog, and Human Liver Microsomes

  Sanna Kaivosaari, Jarmo S. Salonen and Jyrki Taskinen

  Drug Metabolism and Disposition March 2002, 30 (3) 295-300; DOI: https://doi.org/10.1124/dmd.30.3.295
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  Phosphonate O-Deethylation of [4-(4-Bromo-2-Cyano-Phenylcarbamoyl) Benzyl]-Phosphonic Acid Diethyl Ester, a Lipoprotein Lipase-Promoting Agent, Catalyzed by Cytochrome P450 2C8 and 3A4 in Human Liver Microsomes

  Yujiro Morioka, Makiko Otsu, Shinsaku Naito and Teruko Imai

  Drug Metabolism and Disposition March 2002, 30 (3) 301-306; DOI: https://doi.org/10.1124/dmd.30.3.301
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  Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency

  Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans and Jan van Eijkeren

  Drug Metabolism and Disposition March 2002, 30 (3) 307-313; DOI: https://doi.org/10.1124/dmd.30.3.307
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  Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives

  Wenjiang Zhang, Yamini Ramamoorthy, Tansel Kilicarslan, Helma Nolte, Rachel F. Tyndale and Edward M. Sellers

  Drug Metabolism and Disposition March 2002, 30 (3) 314-318; DOI: https://doi.org/10.1124/dmd.30.3.314
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  Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism

  Barbara J. Ring, Jennifer S. Gillespie, James A. Eckstein and Steven A. Wrighton

  Drug Metabolism and Disposition March 2002, 30 (3) 319-323; DOI: https://doi.org/10.1124/dmd.30.3.319
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  Glucuronidation of Acetaminophen Catalyzed by Multiple Rat Phenol UDP-Glucuronosyltransferases

  Fay K. Kessler, Marissa R. Kessler, Diana J. Auyeung and Joseph K. Ritter

  Drug Metabolism and Disposition March 2002, 30 (3) 324-330; DOI: https://doi.org/10.1124/dmd.30.3.324
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  Glutathione and Mercapturic Acid Conjugates of Sulofenur and Their Activity against a Human Colon Cancer Cell Line

  Xiangming Guan, Brianna N. Hoffman, Douglas C. McFarland, Kysa K. Gilkerson, Chandradhar Dwivedi, Angela K. Erickson, Scott Bebensee and Jill Pellegrini

  Drug Metabolism and Disposition March 2002, 30 (3) 331-335; DOI: https://doi.org/10.1124/dmd.30.3.331
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  The Gastroprokinetic and Antiemetic Drug Metoclopramide Is a Substrate and Inhibitor of Cytochrome P450 2D6

  Z. Desta, G. M. Wu, A. M. Morocho and D. A. Flockhart

  Drug Metabolism and Disposition March 2002, 30 (3) 336-343; DOI: https://doi.org/10.1124/dmd.30.3.336
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  Chiral Pharmacokinetics and Inversion of Enantiomers of a New Quinoxaline Topoisomerase IIβ Poison in the Rat

  Hui Zheng, Chun Jiang, Ming H. Chiu, Joseph M. Covey and Kenneth K. Chan

  Drug Metabolism and Disposition March 2002, 30 (3) 344-348; DOI: https://doi.org/10.1124/dmd.30.3.344
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  The Alkaloid Rutaecarpine Is a Selective Inhibitor of Cytochrome P450 1A in Mouse and Human Liver Microsomes

  Yune-Fang Ueng, Woan-Ching Jan, Lie-Chwen Lin, Ta-Liang Chen, F. Peter Guengerich and Chieh-Fu Chen

  Drug Metabolism and Disposition March 2002, 30 (3) 349-353; DOI: https://doi.org/10.1124/dmd.30.3.349