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Research ArticleArticle

Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency

Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans and Jan van Eijkeren
Drug Metabolism and Disposition March 2002, 30 (3) 307-313; DOI: https://doi.org/10.1124/dmd.30.3.307

Article Information

vol. 30 no. 3 307-313
DOI 
https://doi.org/10.1124/dmd.30.3.307
PubMed 
11854150
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 10, 2001
  • Accepted November 19, 2001
  • Published online March 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Bert Haenen1,
  2. Cathy Rompelberg1,
  3. Klaas van Twillert1,
  4. Martin Hamzink1,
  5. Jan Dormans2 and
  6. Jan van Eijkeren1
  1. 1Laboratory of Exposure Assessment and Environmental Epidemiology (B.H., C.R., K.v.T., M.H., J.v.E.) and 2Laboratory for Pathology and Immunobiology (J.D.), National Institute of Public Health and the Environment, Bilthoven, The Netherlands
  1. Dr. H. E. M. G. Haenen, Laboratory of Exposure Assessment and Environmental Epidemiology, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. E-mail:bert.haenen{at}rivm.nl
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Research ArticleArticle

Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency

Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans and Jan van Eijkeren
Drug Metabolism and Disposition March 1, 2002, 30 (3) 307-313; DOI: https://doi.org/10.1124/dmd.30.3.307
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