Table of Contents

Articles

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  Absorption and Metabolism of Flavonoids in the Caco-2 Cell Culture Model and a Perused Rat Intestinal Model

  Yan Liu and Ming Hu

  Drug Metabolism and Disposition April 2002, 30 (4) 370-377; DOI: https://doi.org/10.1124/dmd.30.4.370
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  In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1

  Thomas K. H. Chang, Jie Chen and Salete A. Benetton

  Drug Metabolism and Disposition April 2002, 30 (4) 378-384; DOI: https://doi.org/10.1124/dmd.30.4.378
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  Polymorphic Variants (CYP2C9*3 and CYP2C9*5) and the F114L Active Site Mutation of CYP2C9: Effect on Atypical Kinetic Metabolism Profiles

  Timothy S. Tracy, J. Matthew Hutzler, Robert L. Haining, Allan E. Rettie, Matthew A. Hummel and Leslie J. Dickmann

  Drug Metabolism and Disposition April 2002, 30 (4) 385-390; DOI: https://doi.org/10.1124/dmd.30.4.385
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  Interaction of Irinotecan (CPT-11) and Its Active Metabolite 7-Ethyl-10-Hydroxycamptothecin (SN-38) with Human Cytochrome P450 Enzymes

  Nobumitsu Hanioka, Shogo Ozawa, Hideto Jinno, Toshiko Tanaka-Kagawa, Tetsuji Nishimura, Masanori Ando and Jun-ichi Sawada

  Drug Metabolism and Disposition April 2002, 30 (4) 391-396; DOI: https://doi.org/10.1124/dmd.30.4.391
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  Glucuronidation: An Important Mechanism for Detoxification of Benzo[a]Pyrene Metabolites in Aerodigestive Tract Tissues

  Zhong Zheng, Jia-Long Fang and Philip Lazarus

  Drug Metabolism and Disposition April 2002, 30 (4) 397-403; DOI: https://doi.org/10.1124/dmd.30.4.397
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  Development of an in Vitro Screening Model for the Biosynthesis of Acyl Glucuronide Metabolites and the Assessment of Their Reactivity toward Human Serum Albumin

  Sebastien Bolze, Norbert Bromet, Croisine Gay-Feutry, Frederic Massiere, Roselyne Boulieu and Thierry Hulot

  Drug Metabolism and Disposition April 2002, 30 (4) 404-413; DOI: https://doi.org/10.1124/dmd.30.4.404
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  Reductive Metabolism of an α,β-Ketoalkyne, 4-Phenyl-3-Butyn-2-One, by Rat Liver Preparations

  Shigeyuki Kitamura, Yoichi Kohno, Yuji Okamoto, Mitsuhiro Takeshita and Shigeru Ohta

  Drug Metabolism and Disposition April 2002, 30 (4) 414-420; DOI: https://doi.org/10.1124/dmd.30.4.414
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  Distribution of Brimonidine into Anterior and Posterior Tissues of Monkey, Rabbit, and Rat Eyes

  Andrew A. Acheampong, Martha Shackleton, Brian John, James Burke, Larry Wheeler and Diane Tang-Liu

  Drug Metabolism and Disposition April 2002, 30 (4) 421-429; DOI: https://doi.org/10.1124/dmd.30.4.421
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  Disposition of the Selective Cholesterol Absorption Inhibitor Ezetimibe in Healthy Male Subjects

  James E. Patrick, Teddy Kosoglou, Kathe L. Stauber, Kevin B. Alton, Stephen E. Maxwell, Yali Zhu, Paul Statkevich, Robert Iannucci, Swapan Chowdhury, Melton Affrime and Mitchell N. Cayen

  Drug Metabolism and Disposition April 2002, 30 (4) 430-437; DOI: https://doi.org/10.1124/dmd.30.4.430
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  Regioselective Metabolism of Taxoids by Human CYP3A4 and 2C8: Structure-Activity Relationship

  Thierry Cresteil, Bernard Monsarrat, Joelle Dubois, Michelle Sonnier, Paul Alvinerie and Françoise Gueritte

  Drug Metabolism and Disposition April 2002, 30 (4) 438-445; DOI: https://doi.org/10.1124/dmd.30.4.438
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  Determination of Acetaminophen-Protein Adducts in Mouse Liver and Serum and Human Serum after Hepatotoxic Doses of Acetaminophen Using High-Performance Liquid Chromatography with Electrochemical Detection

  Kenneth L. Muldrew, Laura P. James, Leslie Coop, Sandra S. McCullough, Howard P. Hendrickson, Jack A. Hinson and Philip R. Mayeux

  Drug Metabolism and Disposition April 2002, 30 (4) 446-451; DOI: https://doi.org/10.1124/dmd.30.4.446
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  CYP3A4 Active Site Volume Modification by Mutagenesis of Leucine 211

  Stephen M. Fowler, John M. Taylor, Thomas Friedberg, C. Roland Wolf and Robert J. Riley

  Drug Metabolism and Disposition April 2002, 30 (4) 452-456; DOI: https://doi.org/10.1124/dmd.30.4.452
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  Delineating the Contribution of Secretory Transporters in the Efflux of Etoposide Using Madin-Darby Canine Kidney (MDCK) Cells Overexpressing P-Glycoprotein (Pgp), Multidrug Resistance-Associated Protein (MRP1), and Canalicular Multispecific Organic Anion Transporter (cMOAT)

  Ailan Guo, William Marinaro, Peidi Hu and Patrick J. Sinko

  Drug Metabolism and Disposition April 2002, 30 (4) 457-463; DOI: https://doi.org/10.1124/dmd.30.4.457
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  The Oxidative Biotransformation of Losoxantrone (CI-941)

  Ulf D. Renner, Georgios Piperopoulos, Rolf Gebhardt, Gerhard Ehninger and Klaus-Peter Zeller

  Drug Metabolism and Disposition April 2002, 30 (4) 464-478; DOI: https://doi.org/10.1124/dmd.30.4.464