Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Rapid CommunicationShort Communication

Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5′-Untranslated Region and Exon 28

Masaya Itoda, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Norie Murayama, Seiichi Ishida, Kimie Sai, Michiyo Nagano, Hiroshi Suzuki, Yuichi Sugiyama, Shogo Ozawa and Jun-ichi Sawada
Drug Metabolism and Disposition April 2002, 30 (4) 363-364; DOI: https://doi.org/10.1124/dmd.30.4.363
Masaya Itoda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshiro Saito
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akiko Soyama
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mayumi Saeki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Norie Murayama
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seiichi Ishida
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimie Sai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michiyo Nagano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroshi Suzuki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuichi Sugiyama
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shogo Ozawa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jun-ichi Sawada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

We found nucleotide variability in the 5′-upstream region and exonic sequences of a gene-encoding canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2 (cMOAT/MRP2) by polymerase chain reaction-based sequencing using genomic DNA from 72 established cell lines derived from 72 Japanese individuals. Four single nucleotide polymorphisms (SNPs) were found in the 5′-untranslational region and 21 in the exonic regions. Of them, 14 were nonsynonymous SNPs. One deletion of seven consecutive adenines resulting in a frameshift variant was also found. Four SNPs, c-24t, g1249a (V417I), c2366t (S789F), and c3972t (I1324I), were the same as those recently reported. A strong association was found between c-24t (5′-untranslated region) and c3972t (exon 28), with the promoter activity of the former worth being compared.

Footnotes

  • This study was supported in part by the Program for Promotion of Fundamental Studies in Health Sciences (MPJ-6) of the Organization for Pharmaceutical Safety and Research of Japan.

  • Abbreviations used are::
    SNP
    single nucleotide polymorphism
    TM
    transmembrane domain
    cMOAT/MRP2
    canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2
    • Received July 31, 2001.
    • Accepted December 17, 2001.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 30 (4)
Drug Metabolism and Disposition
Vol. 30, Issue 4
1 Apr 2002
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5′-Untranslated Region and Exon 28
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Rapid CommunicationShort Communication

Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5′-Untranslated Region and Exon 28

Masaya Itoda, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Norie Murayama, Seiichi Ishida, Kimie Sai, Michiyo Nagano, Hiroshi Suzuki, Yuichi Sugiyama, Shogo Ozawa and Jun-ichi Sawada
Drug Metabolism and Disposition April 1, 2002, 30 (4) 363-364; DOI: https://doi.org/10.1124/dmd.30.4.363

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Rapid CommunicationShort Communication

Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5′-Untranslated Region and Exon 28

Masaya Itoda, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Norie Murayama, Seiichi Ishida, Kimie Sai, Michiyo Nagano, Hiroshi Suzuki, Yuichi Sugiyama, Shogo Ozawa and Jun-ichi Sawada
Drug Metabolism and Disposition April 1, 2002, 30 (4) 363-364; DOI: https://doi.org/10.1124/dmd.30.4.363
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results and Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Preincubation Effects on Inhibition of OCT1 by CsA
  • Carbamazepine Metabolite and Hypersensitivity Reactions
  • SULT4A1 Preserves Mitochondrial Function
Show more Short Communication

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics