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Imipramine N-Glucuronidation in Human Liver Microsomes: Biphasic Kinetics and Characterization of UDP-Glucuronosyltransferase Isoforms

Miki Nakajima, Eriko Tanaka, Tomo Kobayashi, Noriko Ohashi, Toshiyuki Kume and Tsuyoshi Yokoi
Drug Metabolism and Disposition June 2002, 30 (6) 636-642; DOI: https://doi.org/10.1124/dmd.30.6.636

Article Information

vol. 30 no. 6 636-642
DOI 
https://doi.org/10.1124/dmd.30.6.636
PubMed 
12019188
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 28, 2001
  • Accepted February 19, 2002
  • Published online June 1, 2002.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Miki Nakajima1,
  2. Eriko Tanaka1,
  3. Tomo Kobayashi1,
  4. Noriko Ohashi2,
  5. Toshiyuki Kume2 and
  6. Tsuyoshi Yokoi1
  1. 1Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (M.N., E.T., T.Ko., T.Y.); and 2Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan (N.O., T.Ku.)
  1. Miki Nakajima, Ph.D., Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi 13-1, Kanazawa 920-0934, Japan. E-mail: nmiki{at}kenroku.kanazawa-u.ac.jp
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Research ArticleArticle

Imipramine N-Glucuronidation in Human Liver Microsomes: Biphasic Kinetics and Characterization of UDP-Glucuronosyltransferase Isoforms

Miki Nakajima, Eriko Tanaka, Tomo Kobayashi, Noriko Ohashi, Toshiyuki Kume and Tsuyoshi Yokoi
Drug Metabolism and Disposition June 1, 2002, 30 (6) 636-642; DOI: https://doi.org/10.1124/dmd.30.6.636
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