Intestinal Transport of Irinotecan in Caco-2 Cells and MDCK II Cells Overexpressing Efflux Transporters Pgp, cMOAT, and MRP1

Patrick J. Sinko, Ph.D., RPh, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020. E-mail: sinko{at}rci.rutgers.edu

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	Abstract	Full	Pdf
Jun 2002	86	124	201
Jul 2002	58	154	185
Aug 2002	19	77	85
Sep 2002	18	74	56
Oct 2002	40	97	40
Nov 2002	19	55	32
Dec 2002	9	40	35
Jan 2003	6	52	47
Feb 2003	13	59	41
Mar 2003	7	65	29
Apr 2003	6	43	23
May 2003	1	41	29
Jun 2003	6	40	19
Jul 2003	9	43	49
Aug 2003	18	44	30
Sep 2003	12	54	27
Oct 2003	21	63	39
Nov 2003	18	80	56
Dec 2003	22	56	41
Jan 2004	20	50	38
Feb 2004	8	58	30
Mar 2004	30	71	30
Apr 2004	21	64	39
May 2004	21	57	39
Jun 2004	19	74	40
Jul 2004	20	75	43
Aug 2004	14	66	36
Sep 2004	12	69	21
Oct 2004	27	124	54
Nov 2004	20	106	65
Dec 2004	22	77	39
Jan 2005	40	110	49
Feb 2005	19	76	49
Mar 2005	22	73	55
Apr 2005	16	64	32
May 2005	9	43	19
Jun 2005	10	64	42
Jul 2005	11	75	26
Aug 2005	11	59	33
Sep 2005	9	49	30
Oct 2005	12	66	35
Nov 2005	13	58	34
Dec 2005	12	40	24
Jan 2006	18	37	19
Feb 2006	11	45	21
Mar 2006	12	73	30
Apr 2006	15	32	22
May 2006	8	28	26
Jun 2006	9	50	27
Jul 2006	7	20	17
Aug 2006	11	41	30
Sep 2006	20	24	25
Oct 2006	11	49	31
Nov 2006	25	49	26
Dec 2006	9	35	17
Jan 2007	12	27	30
Feb 2007	8	43	32
Mar 2007	10	45	33
Apr 2007	22	28	28
May 2007	14	30	25
Jun 2007	13	29	28
Jul 2007	14	31	31
Aug 2007	10	28	27
Sep 2007	14	35	27
Oct 2007	15	44	38
Nov 2007	11	32	24
Dec 2007	9	25	14
Jan 2008	16	27	29
Feb 2008	8	19	25
Mar 2008	22	22	22
Apr 2008	12	47	29
May 2008	21	26	19
Jun 2008	16	40	28
Jul 2008	16	65	29
Aug 2008	19	42	30
Sep 2008	22	34	28
Oct 2008	16	42	25
Nov 2008	10	33	29
Dec 2008	9	26	19
Jan 2009	8	16	17
Feb 2009	21	22	19
Mar 2009	28	23	29
Apr 2009	14	26	16
May 2009	14	26	20
Jun 2009	9	20	16
Jul 2009	18	22	18
Aug 2009	17	19	15
Sep 2009	25	35	25
Oct 2009	17	36	19
Nov 2009	12	23	15
Dec 2009	24	19	11
Jan 2010	34	36	25
Feb 2010	20	28	23
Mar 2010	39	17	20
Apr 2010	45	26	16
May 2010	38	45	30
Jun 2010	48	32	23
Jul 2010	28	21	20
Aug 2010	27	32	25
Sep 2010	38	36	28
Oct 2010	22	36	33
Nov 2010	38	22	24
Dec 2010	37	15	16
Jan 2011	39	25	32
Feb 2011	26	31	31
Mar 2011	33	37	36
Apr 2011	27	19	17
May 2011	20	26	21
Jun 2011	45	19	27
Jul 2011	40	16	15
Aug 2011	23	35	27
Sep 2011	35	36	28
Oct 2011	22	32	25
Nov 2011	33	39	28
Dec 2011	32	28	27
Jan 2012	24	25	21
Feb 2012	32	29	21
Mar 2012	25	50	21
Apr 2012	24	43	24
May 2012	42	27	28
Jun 2012	29	32	19
Jul 2012	23	34	28
Aug 2012	29	24	28
Sep 2012	22	17	19
Oct 2012	31	19	25
Nov 2012	23	15	36
Dec 2012	22	16	29
Jan 2013	28	27	28
Feb 2013	32	20	29
Mar 2013	14	16	27
Apr 2013	24	36	35
May 2013	21	25	30
Jun 2013	23	18	17
Jul 2013	31	20	39
Aug 2013	8	6	19
Sep 2013	26	19	20
Oct 2013	33	16	19
Nov 2013	10	21	23
Dec 2013	22	8	13
Jan 2014	28	19	24
Feb 2014	22	16	28
Mar 2014	33	23	31
Apr 2014	23	26	34
May 2014	29	21	20
Jun 2014	18	25	28
Jul 2014	19	18	16
Aug 2014	30	13	20
Sep 2014	31	22	19
Oct 2014	30	14	18
Nov 2014	12	22	16
Dec 2014	11	21	14
Jan 2015	19	30	23
Feb 2015	19	34	17
Mar 2015	23	30	19
Apr 2015	15	24	12
May 2015	23	15	12
Jun 2015	17	19	14
Jul 2015	17	29	22
Aug 2015	6	16	9
Sep 2015	15	21	10
Oct 2015	19	23	18
Nov 2015	26	27	20
Dec 2015	14	13	4
Jan 2016	19	18	17
Feb 2016	7	14	10
Mar 2016	10	20	26
Apr 2016	11	21	15
May 2016	39	10	27
Jun 2016	44	11	10
Jul 2016	28	18	16
Aug 2016	25	18	9
Sep 2016	33	14	16
Oct 2016	22	25	21
Nov 2016	11	26	20
Dec 2016	8	37	7
Jan 2017	1	34	6
Feb 2017	5	33	14
Mar 2017	7	44	21
Apr 2017	3	35	9
May 2017	3	43	19
Jun 2017	3	40	10
Jul 2017	3	40	16
Aug 2017	0	40	6
Sep 2017	2	23	4
Oct 2017	3	44	10
Nov 2017	7	49	9
Dec 2017	0	45	8
Jan 2018	6	44	14
Feb 2018	6	42	6
Mar 2018	15	36	15
Apr 2018	8	29	16
May 2018	1	38	12
Jun 2018	3	17	9
Jul 2018	4	17	16
Aug 2018	3	31	16
Sep 2018	2	37	11
Oct 2018	5	60	9
Nov 2018	4	73	13
Dec 2018	67	28	9
Jan 2019	74	4	3
Feb 2019	66	3	2
Mar 2019	48	5	3
Apr 2019	34	1	1
May 2019	41	2	6
Jun 2019	39	2	5
Jul 2019	18	7	2
Aug 2019	20	4	3
Sep 2019	27	5	4
Oct 2019	31	10	6
Nov 2019	27	4	2
Dec 2019	39	10	5
Jan 2020	29	5	1
Feb 2020	31	2	1
Mar 2020	12	5	4
Apr 2020	26	8	7
May 2020	24	2	3
Jun 2020	24	5	2
Jul 2020	25	1	4
Aug 2020	25	1	5
Sep 2020	33	1	2
Oct 2020	32	2	2
Nov 2020	30	2	1
Dec 2020	16	7	4
Jan 2021	33	9	3
Feb 2021	17	8	5
Mar 2021	39	5	3
Apr 2021	32	3	0
May 2021	44	2	1
Jun 2021	23	3	5
Jul 2021	14	8	2
Aug 2021	14	4	1
Sep 2021	18	4	7
Oct 2021	27	6	9
Nov 2021	21	4	5
Dec 2021	27	1	7
Jan 2022	29	3	7
Feb 2022	19	4	5
Mar 2022	21	2	3
Apr 2022	35	9	2
May 2022	22	3	4
Jun 2022	24	4	2