Table of Contents

Articles

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  Pharmacokinetic-Pharmacodynamic Analysis of the Glucose-Lowering Effect of Metformin in Diabetic Rats Reveals First-Pass Pharmacodynamic Effect

  David Stepensky, Michael Friedman, Itamar Raz and Amnon Hoffman

  Drug Metabolism and Disposition August 2002, 30 (8) 861-868; DOI: https://doi.org/10.1124/dmd.30.8.861
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  Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy andN-Desmethyl Metabolites and Isomerization oftrans-4-Hydroxytamoxifen

  H. Kim Crewe, Lisa M. Notley, Rebecca M. Wunsch, Martin S. Lennard and Elizabeth M. J. Gillam

  Drug Metabolism and Disposition August 2002, 30 (8) 869-874; DOI: https://doi.org/10.1124/dmd.30.8.869
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  Kinetic Analysis of the Reactions of 4-Hydroperoxycyclophosphamide and Acrolein With Glutathione, Mesna, and Wr-1065

  Kirk A. Tacka, James C. Dabrowiak, Jerry Goodisman and Abdul-Kader Souid

  Drug Metabolism and Disposition August 2002, 30 (8) 875-882; DOI: https://doi.org/10.1124/dmd.30.8.875
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  Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7

  J. Andrew Williams, Barbara J. Ring, Varon E. Cantrell, David R. Jones, James Eckstein, Kenneth Ruterbories, Mitchell A. Hamman, Stephen D. Hall and Steven A. Wrighton

  Drug Metabolism and Disposition August 2002, 30 (8) 883-891; DOI: https://doi.org/10.1124/dmd.30.8.883
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  Prediction of Hepatic Clearance and Availability by Cryopreserved Human Hepatocytes: An Application of Serum Incubation Method

  Yoshihiro Shibata, Hiroyuki Takahashi, Masato Chiba and Yasuyuki Ishii

  Drug Metabolism and Disposition August 2002, 30 (8) 892-896; DOI: https://doi.org/10.1124/dmd.30.8.892
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  Glucuronidation and Sulfation of the Tea Flavonoid (−)-Epicatechin by the Human and Rat Enzymes

  Jaya Bharathi Vaidyanathan and Thomas Walle

  Drug Metabolism and Disposition August 2002, 30 (8) 897-903; DOI: https://doi.org/10.1124/dmd.30.8.897
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  Sex Difference in Inhibition of In Vitro Mexazolam Metabolism by Various 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors in Rat Liver Microsomes

  Michi Ishigami, Wataru Takasaki, Toshihiko Ikeda, Toru Komai, Kiyomi Ito and Yuichi Sugiyama

  Drug Metabolism and Disposition August 2002, 30 (8) 904-910; DOI: https://doi.org/10.1124/dmd.30.8.904
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  Cytochrome P450 2E1 (CYP2E1) is Essential for Acrylonitrile Metabolism to Cyanide: Comparative Studies Using CYP2E1-Null and Wild-Type Mice

  Hongbing Wang, Brian Chanas and Burhan I. Ghanayem

  Drug Metabolism and Disposition August 2002, 30 (8) 911-917; DOI: https://doi.org/10.1124/dmd.30.8.911
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  Role of Constitutive Androstane Receptor in the In Vivo Induction of Mrp3 and CYP2B1/2 by Phenobarbital

  Hao Xiong, Kouichi Yoshinari, Kim L. R. Brouwer and Masahiko Negishi

  Drug Metabolism and Disposition August 2002, 30 (8) 918-923; DOI: https://doi.org/10.1124/dmd.30.8.918
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  Intestinal Absorption Enhancement of the Ester Prodrug Tenofovir Disoproxil Fumarate through Modulation of the Biochemical Barrier by Defined Ester Mixtures

  J. van Gelder, S. Deferme, L. Naesens, E. De Clercq, G. van den Mooter, R. Kinget and P. Augustijns

  Drug Metabolism and Disposition August 2002, 30 (8) 924-930; DOI: https://doi.org/10.1124/dmd.30.8.924
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  Amino Acid Residues Affecting the Activities of Human Cytochrome P450 2C9 and 2C19

  Toshiro Niwa, Akira Kageyama, Kae Kishimoto, Yoshiyasu Yabusaki, Fumihide Ishibashi and Masanao Katagiri

  Drug Metabolism and Disposition August 2002, 30 (8) 931-936; DOI: https://doi.org/10.1124/dmd.30.8.931
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  Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma

  Cornelis E. C. A. Hop, Yanfeng Wang, Sanjeev Kumar, Maria Victoria Silva Elipe, Conrad E. Raab, Dennis C. Dean, Grace K. Poon, Carol-Ann Keohane, John Strauss, Shuet-Hing L. Chiu, Neil Curtis, Jason Elliott, Ute Gerhard, Karen Locker, Denise Morrison, Russell Mortishire-Smith, Steven Thomas, Alan P. Watt and David C. Evans

  Drug Metabolism and Disposition August 2002, 30 (8) 937-943; DOI: https://doi.org/10.1124/dmd.30.8.937
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  Phenol Sulfotransferase, ST1A3, as the Main Enzyme Catalyzing Sulfation of Troglitazone in Human Liver

  Wataru Honma, Miki Shimada, Hironobu Sasano, Shogo Ozawa, Masaaki Miyata, Kiyoshi Nagata, Toshihiko Ikeda and Yasushi Yamazoe

  Drug Metabolism and Disposition August 2002, 30 (8) 944-949; DOI: https://doi.org/10.1124/dmd.30.8.944