Prediction of Hepatic Clearance and Availability by Cryopreserved Human Hepatocytes: An Application of Serum Incubation Method

Yoshihiro Shibata, Drug Metabolism, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3 Techno-park Oho, Tsukuba, Ibaraki 300-2611, Japan. E-mail:sibatayh{at}banyu.co.jp

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: July 2002 to December 2020

	Abstract	Full	Pdf
Jul 2002	122	70	284
Aug 2002	51	64	220
Sep 2002	29	47	96
Oct 2002	47	73	47
Nov 2002	18	38	47
Dec 2002	7	10	27
Jan 2003	6	22	41
Feb 2003	5	37	33
Mar 2003	7	44	22
Apr 2003	4	28	23
May 2003	8	44	32
Jun 2003	11	48	24
Jul 2003	14	36	33
Aug 2003	6	39	38
Sep 2003	7	50	65
Oct 2003	18	60	76
Nov 2003	13	53	31
Dec 2003	6	43	34
Jan 2004	13	75	61
Feb 2004	11	57	42
Mar 2004	16	62	55
Apr 2004	14	37	45
May 2004	13	37	54
Jun 2004	18	52	48
Jul 2004	18	58	57
Aug 2004	24	58	41
Sep 2004	24	50	43
Oct 2004	23	70	37
Nov 2004	16	49	38
Dec 2004	16	56	43
Jan 2005	23	62	23
Feb 2005	18	77	41
Mar 2005	12	57	56
Apr 2005	5	35	51
May 2005	8	39	26
Jun 2005	9	40	45
Jul 2005	14	47	51
Aug 2005	8	43	36
Sep 2005	7	36	46
Oct 2005	8	53	41
Nov 2005	8	40	32
Dec 2005	6	44	18
Jan 2006	9	55	15
Feb 2006	6	60	24
Mar 2006	11	76	34
Apr 2006	5	43	29
May 2006	11	41	24
Jun 2006	2	31	16
Jul 2006	8	31	21
Aug 2006	8	28	25
Sep 2006	12	38	39
Oct 2006	10	51	37
Nov 2006	14	29	28
Dec 2006	5	39	24
Jan 2007	10	36	27
Feb 2007	14	36	34
Mar 2007	11	22	25
Apr 2007	13	33	35
May 2007	14	35	32
Jun 2007	14	31	39
Jul 2007	8	30	22
Aug 2007	8	36	27
Sep 2007	6	46	34
Oct 2007	24	37	36
Nov 2007	13	51	36
Dec 2007	6	28	20
Jan 2008	5	34	25
Feb 2008	10	44	46
Mar 2008	10	39	25
Apr 2008	9	39	30
May 2008	6	29	23
Jun 2008	5	40	25
Jul 2008	16	58	32
Aug 2008	14	31	23
Sep 2008	27	33	24
Oct 2008	16	44	41
Nov 2008	15	25	22
Dec 2008	5	29	28
Jan 2009	8	27	32
Feb 2009	13	27	28
Mar 2009	21	44	44
Apr 2009	16	27	28
May 2009	9	24	27
Jun 2009	6	23	23
Jul 2009	10	24	27
Aug 2009	13	35	25
Sep 2009	19	20	22
Oct 2009	29	26	20
Nov 2009	29	12	13
Dec 2009	20	12	15
Jan 2010	40	33	36
Feb 2010	43	11	19
Mar 2010	30	31	27
Apr 2010	22	26	24
May 2010	19	37	20
Jun 2010	20	25	18
Jul 2010	25	24	25
Aug 2010	11	32	14
Sep 2010	13	31	21
Oct 2010	25	20	13
Nov 2010	14	24	21
Dec 2010	21	26	16
Jan 2011	26	25	17
Feb 2011	11	30	21
Mar 2011	43	43	42
Apr 2011	29	16	27
May 2011	28	13	17
Jun 2011	21	15	32
Jul 2011	35	10	25
Aug 2011	30	17	22
Sep 2011	34	32	23
Oct 2011	35	31	20
Nov 2011	32	19	24
Dec 2011	28	20	21
Jan 2012	38	21	23
Feb 2012	48	19	29
Mar 2012	23	28	33
Apr 2012	34	32	23
May 2012	45	54	36
Jun 2012	44	44	31
Jul 2012	30	36	30
Aug 2012	24	30	47
Sep 2012	44	31	40
Oct 2012	60	44	49
Nov 2012	45	32	57
Dec 2012	26	32	58
Jan 2013	35	35	46
Feb 2013	51	31	28
Mar 2013	34	24	54
Apr 2013	50	29	51
May 2013	62	35	57
Jun 2013	24	11	22
Jul 2013	20	11	14
Aug 2013	16	14	20
Sep 2013	38	9	17
Oct 2013	35	17	27
Nov 2013	21	7	12
Dec 2013	21	15	18
Jan 2014	24	16	17
Feb 2014	34	20	27
Mar 2014	39	10	21
Apr 2014	30	33	30
May 2014	35	12	18
Jun 2014	29	14	17
Jul 2014	35	30	26
Aug 2014	35	27	38
Sep 2014	38	17	36
Oct 2014	44	22	39
Nov 2014	36	11	32
Dec 2014	19	15	24
Jan 2015	32	14	28
Feb 2015	21	16	36
Mar 2015	29	16	25
Apr 2015	18	17	12
May 2015	28	17	19
Jun 2015	18	23	23
Jul 2015	19	24	28
Aug 2015	26	17	15
Sep 2015	20	14	11
Oct 2015	21	25	21
Nov 2015	11	14	26
Dec 2015	23	9	9
Jan 2016	11	8	20
Feb 2016	20	16	19
Mar 2016	18	14	34
Apr 2016	30	18	31
May 2016	20	23	26
Jun 2016	23	14	21
Jul 2016	27	12	19
Aug 2016	11	19	15
Sep 2016	3	18	14
Oct 2016	8	37	34
Nov 2016	15	49	39
Dec 2016	2	23	16
Jan 2017	4	24	13
Feb 2017	4	32	14
Mar 2017	4	24	15
Apr 2017	2	19	14
May 2017	3	20	15
Jun 2017	3	13	13
Jul 2017	6	13	24
Aug 2017	4	23	18
Sep 2017	4	28	19
Oct 2017	1	36	8
Nov 2017	3	46	22
Dec 2017	4	25	9
Jan 2018	2	46	23
Feb 2018	7	35	15
Mar 2018	2	45	10
Apr 2018	5	38	33
May 2018	4	37	28
Jun 2018	6	80	26
Jul 2018	2	29	18
Aug 2018	4	25	18
Sep 2018	1	33	11
Oct 2018	5	36	25
Nov 2018	4	44	31
Dec 2018	18	15	11
Jan 2019	27	10	11
Feb 2019	28	5	9
Mar 2019	35	3	4
Apr 2019	35	9	2
May 2019	23	10	12
Jun 2019	19	3	10
Jul 2019	24	5	6
Aug 2019	38	4	5
Sep 2019	56	6	12
Oct 2019	46	9	7
Nov 2019	49	11	10
Dec 2019	33	17	7
Jan 2020	40	18	11
Feb 2020	25	5	3
Mar 2020	40	8	5
Apr 2020	21	6	6
May 2020	46	9	12
Jun 2020	38	8	6
Jul 2020	20	10	4
Aug 2020	13	4	5
Sep 2020	35	14	5
Oct 2020	27	21	8
Nov 2020	26	8	6
Dec 2020	1	1	0