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Drug Metabolism & Disposition

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Table of Contents

September 01, 2002; Volume 30,Issue 9

Articles

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    Insights from a Three-Dimensional Model into Ligand Binding to Constitutive Active Receptor
    Li Xiao, Xiaoming Cui, Vincent Madison, Ronald E. White and K.-C. Cheng
    Drug Metabolism and Disposition September 2002, 30 (9) 951-956; DOI: https://doi.org/10.1124/dmd.30.9.951
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    The Interactions of a Selective Protein Kinase C Beta Inhibitor with the Human Cytochromes P450
    Barbara J. Ring, Jennifer S. Gillespie, Shelly N. Binkley, Kristina M. Campanale and Steven A. Wrighton
    Drug Metabolism and Disposition September 2002, 30 (9) 957-961; DOI: https://doi.org/10.1124/dmd.30.9.957
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    Mechanisms of Impaired Biliary Excretion of Acetaminophen Glucuronide after Acute Phenobarbital Treatment or Phenobarbital Pretreatment
    Hao Xiong, Hiroshi Suzuki, Yuichi Sugiyama, Peter J. Meier, Gary M. Pollack and Kim L. R. Brouwer
    Drug Metabolism and Disposition September 2002, 30 (9) 962-969; DOI: https://doi.org/10.1124/dmd.30.9.962
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    Catalytic Specificity of CYP2D Isoforms in Rat and Human
    Toyoko Hiroi, Toshio Chow, Susumu Imaoka and Yoshihiko Funae
    Drug Metabolism and Disposition September 2002, 30 (9) 970-976; DOI: https://doi.org/10.1124/dmd.30.9.970
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    Effects of Bergamottin on Human and Monkey Drug-Metabolizing Enzymes in Primary Cultured Hepatocytes
    Yuan Hua Wen, Jasminder Sahi, Ellen Urda, Shaila Kulkarni, Kelly Rose, Xianxian Zheng, Jacqueline F. Sinclair, Hongbo Cai, Stephen C. Strom and Vsevolod E. Kostrubsky
    Drug Metabolism and Disposition September 2002, 30 (9) 977-984; DOI: https://doi.org/10.1124/dmd.30.9.977
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    Differential Oxidation of Mifepristone by Cytochromes P450 3A4 and 3A5: Selective Inactivation of P450 3A4
    Kishore K. Khan, You Qun He, Maria Almira Correia and James R. Halpert
    Drug Metabolism and Disposition September 2002, 30 (9) 985-990; DOI: https://doi.org/10.1124/dmd.30.9.985
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    N-Glucuronidation of Nicotine and Cotinine in Human: Formation of Cotinine Glucuronide in Liver Microsomes and Lack of Catalysis by 10 Examined UDP-Glucuronosyltransferases
    Omar Ghosheh and Edward M. Hawes
    Drug Metabolism and Disposition September 2002, 30 (9) 991-996; DOI: https://doi.org/10.1124/dmd.30.9.991
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    Effects of Dexamethasone on Aryl (SULT1A1)- and Hydroxysteroid (SULT2A1)-Sulfotransferase Gene Expression in Primary Cultured Human Hepatocytes
    Zhengbo Duanmu, Deborah Locke, Jeffrey Smigelski, Wei Wu, Michael S. Dahn, Charles N. Falany, Thomas A. Kocarek and Melissa Runge-Morris
    Drug Metabolism and Disposition September 2002, 30 (9) 997-1004; DOI: https://doi.org/10.1124/dmd.30.9.997
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    Glucuronidation of Dihydroartemisinin in Vivo and by Human Liver Microsomes and Expressed UDP-Glucuronosyltransferases
    Kenneth F. Ilett, Brian T. Ethell, James L. Maggs, Timothy M. E. Davis, Kevin T. Batty, Brian Burchell, Tran Quang Binh, Le Thi Anh Thu, Nguyen Canh Hung, Munir Pirmohamed, B. Kevin Park and Geoffrey Edwards
    Drug Metabolism and Disposition September 2002, 30 (9) 1005-1012; DOI: https://doi.org/10.1124/dmd.30.9.1005
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    Disposition of a Specific Cyclooxygenase-2 Inhibitor, Valdecoxib, in Human
    Josh J. Yuan, Dai-chang Yang, Ji Y. Zhang, Roy Bible, Aziz Karim and John W. A. Findlay
    Drug Metabolism and Disposition September 2002, 30 (9) 1013-1021; DOI: https://doi.org/10.1124/dmd.30.9.1013
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    Sexual Dimorphism and Tissue Specificity in the Expression of CYP4F Forms in Sprague Dawley Rats
    Auinash Kalsotra, Sayeepriyadarshini Anakk, Christopher L. Boehme and Henry W. Strobel
    Drug Metabolism and Disposition September 2002, 30 (9) 1022-1028; DOI: https://doi.org/10.1124/dmd.30.9.1022
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    Glucocorticoid-Mediated Induction of CYP3A4 is Decreased by Disruption of a Protein: DNA Interaction Distinct from the Pregnane X Receptor Response Element
    Wafaa El-Sankary, Vincent Bombail, G. Gordon Gibson and Nick Plant
    Drug Metabolism and Disposition September 2002, 30 (9) 1029-1034; DOI: https://doi.org/10.1124/dmd.30.9.1029
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    Metabolism of the Endocrine Disruptor Pesticide-Methoxychlor by Human P450s: Pathways Involving a Novel Catechol Metabolite
    Yiding Hu and David Kupfer
    Drug Metabolism and Disposition September 2002, 30 (9) 1035-1042; DOI: https://doi.org/10.1124/dmd.30.9.1035
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Drug Metabolism and Disposition: 30 (9)
Drug Metabolism and Disposition
Vol. 30, Issue 9
1 Sep 2002
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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