Table of Contents

Articles

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  Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases

  S. Casey Laizure, Timothy Mandrell, Naomi M. Gades and Robert B. Parker

  Drug Metabolism and Disposition January 2003, 31 (1) 16-20; DOI: https://doi.org/10.1124/dmd.31.1.16
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  Mouse Liver and Kidney Carboxylesterase (M-LK) Rapidly Hydrolyzes Antitumor Prodrug Irinotecan and the N-Terminal Three Quarter Sequence Determines Substrate Selectivity

  Mingxing Xie, Dongfang Yang, Micheal Wu, Bob Xue and Bingfang Yan

  Drug Metabolism and Disposition January 2003, 31 (1) 21-27; DOI: https://doi.org/10.1124/dmd.31.1.21
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  Mechanism-Based Inactivation of Cytochrome P450 2B6 by a Novel Terminal Acetylene Inhibitor

  Peter W. Fan, Chungang Gu, Sandra A. Marsh and Jeffrey C. Stevens

  Drug Metabolism and Disposition January 2003, 31 (1) 28-36; DOI: https://doi.org/10.1124/dmd.31.1.28
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  Acyl Glucuronidation and Glucosidation of a New and Selective Endothelin ET_A Receptor Antagonist in Human Liver Microsomes

  Cuyue Tang, Jerome H. Hochman, Bennett Ma, Raju Subramanian and Kamlesh P. Vyas

  Drug Metabolism and Disposition January 2003, 31 (1) 37-45; DOI: https://doi.org/10.1124/dmd.31.1.37
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  The Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Phencyclidine

  Monica I. Jushchyshyn, Ute M. Kent and Paul F. Hollenberg

  Drug Metabolism and Disposition January 2003, 31 (1) 46-52; DOI: https://doi.org/10.1124/dmd.31.1.46
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  The Metabolism of Clopidogrel Is Catalyzed by Human Cytochrome P450 3A and Is Inhibited by Atorvastatin

  Thomas A. Clarke and Lucy A. Waskell

  Drug Metabolism and Disposition January 2003, 31 (1) 53-59; DOI: https://doi.org/10.1124/dmd.31.1.53
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  Differences in Cytochrome P450 Forms Involved in the Metabolism ofN,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a Novel Sigma Ligand, in Human Liver and Intestine

  Takahito Yamamoto, Naoko Hagima, Masato Nakamura, Yoshiro Kohno, Kiyoshi Nagata and Yasushi Yamazoe

  Drug Metabolism and Disposition January 2003, 31 (1) 60-66; DOI: https://doi.org/10.1124/dmd.31.1.60
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  Comparative Biotransformation of Radiolabeled [¹⁴C]Omapatrilat and Stable-labeled [¹³C₂]Omapatrilat after Oral Administration to Rats, Dogs, and Humans

  Ramaswamy A. Iyer, Bimal Malhotra, Sanaullah Khan, James Mitroka, Samuel Bonacorsi, Stephen C. Waller, J. Kent Rinehart and Kishin Kripalani

  Drug Metabolism and Disposition January 2003, 31 (1) 67-75; DOI: https://doi.org/10.1124/dmd.31.1.67
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  Metabolism, Pharmacokinetics, and Excretion of a Highly SelectiveN-Methyl-d-aspartate Receptor Antagonist, Traxoprodil, in Human Cytochrome P450 2D6 Extensive and Poor Metabolizers

  Kim Johnson, Ajit Shah, Sarah Jaw-Tsai, James Baxter and Chandra Prakash

  Drug Metabolism and Disposition January 2003, 31 (1) 76-87; DOI: https://doi.org/10.1124/dmd.31.1.76
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  Disposition and Metabolic Fate of Atomoxetine Hydrochloride: Pharmacokinetics, Metabolism, and Excretion in the Fischer 344 Rat and Beagle Dog

  Edward L. Mattiuz, G. Douglas Ponsler, Robert J. Barbuch, Paul G. Wood, John H. Mullen, Richard L. Shugert, Qimin Li, William J. Wheeler, Fengjiun Kuo, Preston C. Conrad and John-Michael Sauer

  Drug Metabolism and Disposition January 2003, 31 (1) 88-97; DOI: https://doi.org/10.1124/dmd.31.1.88
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  Disposition and Metabolic Fate of Atomoxetine Hydrochloride: The Role of CYP2D6 in Human Disposition and Metabolism

  John-Michael Sauer, G. Douglas Ponsler, Edward L. Mattiuz, Amanda J. Long, Jennifer W. Witcher, Holly R. Thomasson and Karl A. Desante

  Drug Metabolism and Disposition January 2003, 31 (1) 98-107; DOI: https://doi.org/10.1124/dmd.31.1.98
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  Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38), an Active Metabolite of Irinotecan (CPT-11), by Human UGT1A1 Variants, G71R, P229Q, and Y486D

  Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Mayumi Saeki, Seiichi Ishida, Tetsuji Nishimura, Masanori Ando, Yoshiro Saito, Shogo Ozawa and Jun-ichi Sawada

  Drug Metabolism and Disposition January 2003, 31 (1) 108-113; DOI: https://doi.org/10.1124/dmd.31.1.108
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  Amino Acid Conjugates: Metabolites of 2-Propylpentanoic Acid (Valproic Acid) in Epileptic Patients

  V. S. Gopaul, W. Tang, K. Farrell and F. S. Abbott

  Drug Metabolism and Disposition January 2003, 31 (1) 114-121; DOI: https://doi.org/10.1124/dmd.31.1.114
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  Metabolism of (S)-5,6-Difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Human Liver Microsomes. Metabolic Activation and Enzyme Kinetics

  Hao Chen, Weiqi Chen, Liang-Shang Gan and Abdul E. Mutlib

  Drug Metabolism and Disposition January 2003, 31 (1) 122-132; DOI: https://doi.org/10.1124/dmd.31.1.122
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  Validation of Serotonin (5-Hydroxtryptamine) as an in Vitro Substrate Probe for Human UDP-Glucuronosyltransferase (UGT) 1A6

  Soundararajan Krishnaswamy, Su X. Duan, Lisa L. von Moltke, David J. Greenblatt and Michael H. Court

  Drug Metabolism and Disposition January 2003, 31 (1) 133-139; DOI: https://doi.org/10.1124/dmd.31.1.133
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  Bisphenol A Glucuronidation and Absorption in Rat Intestine

  Hiroki Inoue, Go Yuki, Hiroshi Yokota and Seiyu Kato

  Drug Metabolism and Disposition January 2003, 31 (1) 140-144; DOI: https://doi.org/10.1124/dmd.31.1.140