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Research ArticleArticle

Bisphenol A Glucuronidation and Absorption in Rat Intestine

Hiroki Inoue, Go Yuki, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 2003, 31 (1) 140-144; DOI: https://doi.org/10.1124/dmd.31.1.140
Hiroki Inoue
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Go Yuki
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Hiroshi Yokota
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Seiyu Kato
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Abstract

Bisphenol A, an environmental estrogen, can be leached from plastic tableware and from the coating of food and drink cans, orally exposing human beings to the compound. The present study focuses on the absorption and metabolism of bisphenol A in the rat intestine, as elucidated experimentally by segmented everted intestine. One hour after the application of 2 μmol of bisphenol A to the mucosal fluid, the absorption of bisphenol A was slightly greater in the colon (48.6%) than in the proximal jejunum (37.5%). In the serosal side, unconjugated bisphenol A appeared in small amounts, increasing distally (maximal 1.6 nmol, colon). Large amounts of the bisphenol A glucuronide were then transported into the serosal side, also increasing distally (proximal, 80.4 nmol; distal, 478.4 nmol). The greatest amount of the glucuronide (∼573 nmol) was excreted into the mucosal side of the small intestine, whereas in the colon, mucosal excretion was minimal (67.2 nmol). On high-dose application of bisphenol A to the mucosal fluid, the transported unconjugated bisphenol A increased markedly throughout the intestine and colon. These results suggest that bisphenol A in the intestinal lumen is glucuronidated almost exclusively during its passage through the intestinal wall.

Footnotes

  • ↵1 Present address: Department of Veterinary Physiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069-8501 Japan.

  • ↵2 Present address: Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069-8501 Japan.

  • This work was supported by the Akiyama Foundation of Japan.

  • Abbreviations used are::
    bisphenol A
    2,2-bis[4-hydroxyphenyl]propane
    HPLC
    high performance liquid chromatography
    MRP
    multidrug resistance associated protein
    • Received May 24, 2002.
    • Accepted October 9, 2002.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 31 (1)
Drug Metabolism and Disposition
Vol. 31, Issue 1
1 Jan 2003
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Research ArticleArticle

Bisphenol A Glucuronidation and Absorption in Rat Intestine

Hiroki Inoue, Go Yuki, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 1, 2003, 31 (1) 140-144; DOI: https://doi.org/10.1124/dmd.31.1.140

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Research ArticleArticle

Bisphenol A Glucuronidation and Absorption in Rat Intestine

Hiroki Inoue, Go Yuki, Hiroshi Yokota and Seiyu Kato
Drug Metabolism and Disposition January 1, 2003, 31 (1) 140-144; DOI: https://doi.org/10.1124/dmd.31.1.140
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