Table of Contents

Articles

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  INDUCTION OF MULTIDRUG RESISTANCE PROTEIN 3 (MRP3) IN VIVO IS INDEPENDENT OF CONSTITUTIVE ANDROSTANE RECEPTOR

  Nathan J. Cherrington, Angela L. Slitt, Jonathan M. Maher, Xiao-Xue Zhang, Jun Zhang, Wendong Huang, Yu-Jui Yvonne Wan, David D. Moore and Curtis D. Klaassen

  Drug Metabolism and Disposition November 2003, 31 (11) 1315-1319; DOI: https://doi.org/10.1124/dmd.31.11.1315
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  USE OF ANTI-(+)-METHAMPHETAMINE MONOCLONAL ANTIBODY TO SIGNIFICANTLY ALTER (+)-METHAMPHETAMINE AND (+)-AMPHETAMINE DISPOSITION IN RATS

  Elizabeth M. Laurenzana, Kelly A. Byrnes-Blake, Alessandra Milesi-Hallé, W. Brooks Gentry, D. Keith Williams and S. Michael Owens

  Drug Metabolism and Disposition November 2003, 31 (11) 1320-1326; DOI: https://doi.org/10.1124/dmd.31.11.1320
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  STUDIES ON THE CHEMICAL REACTIVITY OF DICLOFENAC ACYL GLUCURONIDE WITH GLUTATHIONE: IDENTIFICATION OF DICLOFENAC-S-ACYL-GLUTATHIONE IN RAT BILE

  Mark P. Grillo, Charles G. Knutson, Phillip E. Sanders, Daniel J. Waldon, Fengmei Hua and Joseph A. Ware

  Drug Metabolism and Disposition November 2003, 31 (11) 1327-1336; DOI: https://doi.org/10.1124/dmd.31.11.1327
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  CONSTITUTIVE EXPRESSION OF VARIOUS XENOBIOTIC AND ENDOBIOTIC TRANSPORTER mRNAs IN THE CHOROID PLEXUS OF RATS

  Supratim Choudhuri, Nathan J. Cherrington, Ning Li and Curtis D. Klaassen

  Drug Metabolism and Disposition November 2003, 31 (11) 1337-1345; DOI: https://doi.org/10.1124/dmd.31.11.1337
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  CHARACTERIZATION OF MOUSE SMALL INTESTINAL CYTOCHROME P450 EXPRESSION

  Qing-Yu Zhang, Debbie Dunbar and Laurence S. Kaminsky

  Drug Metabolism and Disposition November 2003, 31 (11) 1346-1351; DOI: https://doi.org/10.1124/dmd.31.11.1346
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  MECHANISM-BASED INHIBITION OF HUMAN LIVER MICROSOMAL CYTOCHROME P450 1A2 BY ZILEUTON, A 5-LIPOXYGENASE INHIBITOR

  Ping Lu, Michael L. Schrag, Donald E. Slaughter, Conrad E. Raab, Magang Shou and A. David Rodrigues

  Drug Metabolism and Disposition November 2003, 31 (11) 1352-1360; DOI: https://doi.org/10.1124/dmd.31.11.1352
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  N-GLUCURONIDATION OF NICOTINE AND COTININE BY HUMAN LIVER MICROSOMES AND HETEROLOGOUSLY EXPRESSED UDP-GLUCURONOSYLTRANSFERASES

  Gwendolyn E. Kuehl and Sharon E. Murphy

  Drug Metabolism and Disposition November 2003, 31 (11) 1361-1368; DOI: https://doi.org/10.1124/dmd.31.11.1361
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  MECHANISM-BASED INACTIVATION OF HUMAN RECOMBINANT P450 2C9 BY THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG SUPROFEN

  John P. O'Donnell, Deepak K. Dalvie, Amit S. Kalgutkar and R. Scott Obach

  Drug Metabolism and Disposition November 2003, 31 (11) 1369-1377; DOI: https://doi.org/10.1124/dmd.31.11.1369
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  TRANSACTIVATION OF GLUCOCORTICOID-INDUCIBLE RAT ARYL SULFOTRANSFERASE (SULT1A1) GENE TRANSCRIPTION

  Hai-Lin Fang, Sarita Shenoy, Zhengbo Duanmu, Thomas A. Kocarek and Melissa Runge-Morris

  Drug Metabolism and Disposition November 2003, 31 (11) 1378-1381; DOI: https://doi.org/10.1124/dmd.31.11.1378
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  PRECLINICAL CHARACTERIZATION OF 2-[3-[3-[(5-ETHYL-4′-FLUORO-2-HYDROXY[1,1′-BIPHENYL]-4-YL)OXY]PROPOXY]-2-PROPYLPHENOXY]BENZOIC ACID METABOLISM: IN VITRO SPECIES COMPARISON AND IN VIVO DISPOSITION IN RATS

  E. J. Perkins, J. W. Cramer, N. A. Farid, M. G. Gadberry, D. A. Jackson, E. L. Mattiuz, D. D. O'Bannon, H. J. Weiss, W. J. Wheeler, P. G. Wood and K. C. Cassidy

  Drug Metabolism and Disposition November 2003, 31 (11) 1382-1390; DOI: https://doi.org/10.1124/dmd.31.11.1382
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  HUMAN CYTOCHROME P450 INHIBITION AND METABOLIC-INTERMEDIATE COMPLEX FORMATION BY GOLDENSEAL EXTRACT AND ITS METHYLENEDIOXYPHENYL COMPONENTS

  Parnali Chatterjee and Michael R. Franklin

  Drug Metabolism and Disposition November 2003, 31 (11) 1391-1397; DOI: https://doi.org/10.1124/dmd.31.11.1391
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  METABOLISM OF ROFECOXIB IN VITRO USING HUMAN LIVER SUBCELLULAR FRACTIONS

  Donald Slaughter, Norihiro Takenaga, Ping Lu, Carol Assang, Deborah J. Walsh, Byron H. Arison, Donghui Cui, Rita A. Halpin, Leslie A. Geer, Kamlesh P. Vyas and Thomas A. Baillie

  Drug Metabolism and Disposition November 2003, 31 (11) 1398-1408; DOI: https://doi.org/10.1124/dmd.31.11.1398
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  METABOLISM AND DISPOSITION OF NOVEL DES-FLUORO QUINOLONE GARENOXACIN IN EXPERIMENTAL ANIMALS AND AN INTERSPECIES SCALING OF PHARMACOKINETIC PARAMETERS

  Hiroyoshi Hayakawa, Yoko Fukushima, Hiroshi Kato, Hiroyuki Fukumoto, Takumi Kadota, Hiroyuki Yamamoto, Hiroyuki Kuroiwa, Junko Nishigaki and Akira Tsuji

  Drug Metabolism and Disposition November 2003, 31 (11) 1409-1418; DOI: https://doi.org/10.1124/dmd.31.11.1409
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  PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES

  Richard S. Geary, Rosie Z. Yu, Tanya Watanabe, Scott P. Henry, Greg E. Hardee, Alfred Chappell, John Matson, Henri Sasmor, Len Cummins and Arthur A. Levin

  Drug Metabolism and Disposition November 2003, 31 (11) 1419-1428; DOI: https://doi.org/10.1124/dmd.31.11.1419
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  IDENTIFICATION OF ZOMEPIRAC-S-ACYL-GLUTATHIONE IN VITRO IN INCUBATIONS WITH RAT HEPATOCYTES AND IN VIVO IN RAT BILE

  Mark P. Grillo and Fengmei Hua

  Drug Metabolism and Disposition November 2003, 31 (11) 1429-1436; DOI: https://doi.org/10.1124/dmd.31.11.1429
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  BIOACTIVATION OF THE 3-AMINO-6-CHLOROPYRAZINONE RING IN A THROMBIN INHIBITOR LEADS TO NOVEL DIHYDRO-IMIDAZOLE AND IMIDAZOLIDINE DERIVATIVES: STRUCTURES AND MECHANISM USING ¹³C-LABELS, MASS SPECTROMETRY, AND NMR

  Raju Subramanian, Charles C. Lin, Jonathan Z. Ho, Steven M. Pitzenberger, Maria V. Silva-Elipe, Christopher R. Gibson, Matthew P. Braun, Xiao Yu, James L. Yergey and Rominder Singh

  Drug Metabolism and Disposition November 2003, 31 (11) 1437-1447; DOI: https://doi.org/10.1124/dmd.31.11.1437
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  PHARMACOKINETICS AND METABOLISM OF [¹⁴C]EPLERENONE AFTER ORAL ADMINISTRATION TO HUMANS

  Chyung S. Cook, Loren M. Berry, Roy H. Bible, Jeremy D. Hribar, Elisabeth Hajdu and Norman W. Liu

  Drug Metabolism and Disposition November 2003, 31 (11) 1448-1455; DOI: https://doi.org/10.1124/dmd.31.11.1448