MECHANISM-BASED INHIBITION OF HUMAN LIVER MICROSOMAL CYTOCHROME P450 1A2 BY ZILEUTON, A 5-LIPOXYGENASE INHIBITOR

Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania (P.L., M.L.S., D.E.S., M.S., A.D.R.); and Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey (C.E.R.)

Address correspondence to:
Dr. A. David Rodrigues, Department of Drug Metabolism, WP75A-203, Merck Research Laboratories, West Point PA 19486. E-mail: david_rodrigues{at}merck.com

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	Abstract	Full	Pdf
Oct 2003	67	66	172
Nov 2003	51	133	151
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Feb 2010	21	28	23
Mar 2010	34	17	19
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Jul 2010	26	22	21
Aug 2010	18	41	25
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Apr 2011	24	19	20
May 2011	12	46	28
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Jul 2011	27	30	14
Aug 2011	22	41	31
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Oct 2011	21	30	24
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Jan 2012	26	39	22
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Jul 2014	24	9	9
Aug 2014	9	20	12
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Oct 2014	30	18	25
Nov 2014	21	25	26
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Jan 2015	13	23	9
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Apr 2015	26	14	10
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Jun 2015	28	17	7
Jul 2015	21	77	17
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Sep 2015	12	19	8
Oct 2015	22	24	11
Nov 2015	16	30	10
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Jan 2016	24	10	9
Feb 2016	22	9	7
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Apr 2016	15	23	13
May 2016	17	16	11
Jun 2016	12	36	12
Jul 2016	23	10	7
Aug 2016	16	18	11
Sep 2016	9	8	4
Oct 2016	1	30	6
Nov 2016	3	29	12
Dec 2016	5	25	22
Jan 2017	1	18	2
Feb 2017	1	20	5
Mar 2017	1	24	25
Apr 2017	0	18	9
May 2017	1	28	10
Jun 2017	2	17	1
Jul 2017	3	17	8
Aug 2017	0	24	18
Sep 2017	1	29	7
Oct 2017	7	43	17
Nov 2017	3	31	9
Dec 2017	5	29	5
Jan 2018	2	21	7
Feb 2018	5	28	13
Mar 2018	6	38	17
Apr 2018	3	34	7
May 2018	3	34	13
Jun 2018	2	27	5
Jul 2018	3	29	7
Aug 2018	0	28	10
Sep 2018	4	17	3
Oct 2018	7	21	11
Nov 2018	2	22	12
Dec 2018	21	10	2
Jan 2019	18	1	1
Feb 2019	16	5	4
Mar 2019	40	9	2
Apr 2019	36	2	1
May 2019	19	1	1
Jun 2019	16	1	3
Jul 2019	24	4	4
Aug 2019	21	3	2
Sep 2019	18	1	1
Oct 2019	14	0	0
Nov 2019	42	3	2
Dec 2019	30	9	0
Jan 2020	15	0	0
Feb 2020	9	3	2
Mar 2020	16	11	4
Apr 2020	42	1	1
May 2020	34	2	1
Jun 2020	22	1	0
Jul 2020	5	0	0
Aug 2020	5	2	1
Sep 2020	27	1	0
Oct 2020	20	3	1
Nov 2020	11	0	0
Dec 2020	37	2	1
Jan 2021	22	9	1
Feb 2021	11	14	2
Mar 2021	23	6	2
Apr 2021	23	9	4
May 2021	43	7	2
Jun 2021	19	7	1
Jul 2021	20	4	1
Aug 2021	27	10	3
Sep 2021	15	5	2
Oct 2021	26	6	3
Nov 2021	31	5	2
Dec 2021	33	3	0
Jan 2022	25	2	1