MECHANISM-BASED INACTIVATION OF HUMAN RECOMBINANT P450 2C9 BY THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG SUPROFEN

Address correspondence to:
John P. O'Donnell, Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Groton, CT 06340. E-mail: odonnelljp{at}groton.pfizer.com

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	Abstract	Full	Pdf
Oct 2003	75	51	131
Nov 2003	58	78	174
Dec 2003	45	55	81
Jan 2004	33	66	57
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Mar 2004	25	52	47
Apr 2004	12	28	25
May 2004	18	30	37
Jun 2004	25	50	26
Jul 2004	17	45	23
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Oct 2006	6	23	8
Nov 2006	7	34	24
Dec 2006	5	21	18
Jan 2007	11	28	40
Feb 2007	8	32	28
Mar 2007	6	37	21
Apr 2007	13	26	25
May 2007	5	40	24
Jun 2007	4	39	26
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Oct 2007	15	39	28
Nov 2007	4	33	27
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Jan 2008	3	20	20
Feb 2008	2	23	24
Mar 2008	9	10	14
Apr 2008	12	31	29
May 2008	13	20	20
Jun 2008	16	28	15
Jul 2008	21	39	19
Aug 2008	17	15	12
Sep 2008	14	32	26
Oct 2008	12	26	28
Nov 2008	17	19	21
Dec 2008	7	11	10
Jan 2009	9	16	16
Feb 2009	8	18	15
Mar 2009	12	21	20
Apr 2009	13	9	7
May 2009	6	28	15
Jun 2009	3	16	18
Jul 2009	3	8	17
Aug 2009	4	12	9
Sep 2009	11	11	12
Oct 2009	10	18	17
Nov 2009	11	9	5
Dec 2009	8	13	13
Jan 2010	16	4	9
Feb 2010	12	3	9
Mar 2010	16	7	15
Apr 2010	14	14	12
May 2010	12	24	19
Jun 2010	17	16	16
Jul 2010	17	15	13
Aug 2010	3	7	4
Sep 2010	13	12	11
Oct 2010	12	26	11
Nov 2010	15	17	9
Dec 2010	13	23	13
Jan 2011	8	17	10
Feb 2011	15	23	18
Mar 2011	10	21	16
Apr 2011	17	22	16
May 2011	16	20	16
Jun 2011	16	22	12
Jul 2011	23	12	14
Aug 2011	25	13	20
Sep 2011	16	13	12
Oct 2011	17	6	11
Nov 2011	15	16	19
Dec 2011	29	14	34
Jan 2012	13	13	11
Feb 2012	16	15	16
Mar 2012	29	19	22
Apr 2012	18	28	14
May 2012	26	23	9
Jun 2012	27	26	14
Jul 2012	15	10	8
Aug 2012	16	13	13
Sep 2012	7	12	10
Oct 2012	26	42	23
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Feb 2013	18	10	12
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May 2013	20	17	14
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Jul 2013	14	11	2
Aug 2013	8	8	8
Sep 2013	34	12	8
Oct 2013	20	19	10
Nov 2013	21	9	12
Dec 2013	25	2	4
Jan 2014	8	9	9
Feb 2014	19	13	10
Mar 2014	14	19	9
Apr 2014	21	16	15
May 2014	10	10	6
Jun 2014	9	9	8
Jul 2014	11	5	7
Aug 2014	12	8	14
Sep 2014	8	16	10
Oct 2014	16	11	16
Nov 2014	14	4	10
Dec 2014	12	6	17
Jan 2015	14	6	7
Feb 2015	15	7	8
Mar 2015	10	7	9
Apr 2015	18	3	9
May 2015	7	12	13
Jun 2015	13	9	10
Jul 2015	9	14	13
Aug 2015	14	4	3
Sep 2015	6	8	4
Oct 2015	7	10	8
Nov 2015	7	8	3
Dec 2015	8	6	4
Jan 2016	10	4	10
Feb 2016	11	2	10
Mar 2016	2	5	5
Apr 2016	9	7	13
May 2016	3	6	13
Jun 2016	18	11	13
Jul 2016	10	3	4
Aug 2016	3	5	2
Sep 2016	4	8	6
Oct 2016	1	14	3
Nov 2016	0	10	1
Dec 2016	2	6	5
Jan 2017	0	14	7
Feb 2017	1	15	6
Mar 2017	1	12	5
Apr 2017	1	9	4
May 2017	0	16	5
Jun 2017	0	13	5
Jul 2017	0	9	7
Aug 2017	0	12	7
Sep 2017	2	30	16
Oct 2017	0	15	9
Nov 2017	0	24	7
Dec 2017	0	14	1
Jan 2018	0	17	13
Feb 2018	2	19	8
Mar 2018	0	25	4
Apr 2018	2	22	1
May 2018	2	15	0
Jun 2018	0	14	3
Jul 2018	2	14	5
Aug 2018	1	10	8
Sep 2018	1	13	2
Oct 2018	1	9	7
Nov 2018	1	27	3
Dec 2018	16	5	1
Jan 2019	14	2	3
Feb 2019	7	0	0
Mar 2019	27	2	1
Apr 2019	8	0	0
May 2019	8	1	0
Jun 2019	3	1	3
Jul 2019	18	1	1
Aug 2019	17	2	2
Sep 2019	21	1	1
Oct 2019	15	1	1
Nov 2019	12	0	0
Dec 2019	20	4	0
Jan 2020	18	3	1
Feb 2020	5	6	2
Mar 2020	14	3	0
Apr 2020	12	1	0
May 2020	7	7	4
Jun 2020	6	0	0
Jul 2020	5	3	1
Aug 2020	10	2	4
Sep 2020	9	0	0
Oct 2020	26	2	1
Nov 2020	10	0	0
Dec 2020	20	2	0
Jan 2021	3	7	2