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Research ArticleArticle

THE USE OF DEUTERIUM ISOTOPE EFFECTS TO PROBE THE ACTIVE SITE PROPERTIES, MECHANISM OF CYTOCHROME P450-CATALYZED REACTIONS, AND MECHANISMS OF METABOLICALLY DEPENDENT TOXICITY

Sidney D. Nelson and William F. Trager
Drug Metabolism and Disposition December 2003, 31 (12) 1481-1497; DOI: https://doi.org/10.1124/dmd.31.12.1481

Article Information

vol. 31 no. 12 1481-1497
DOI 
https://doi.org/10.1124/dmd.31.12.1481
PubMed 
14625345
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 2, 2003
  • Accepted July 1, 2003
  • Published online November 18, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sidney D. Nelson and
  2. William F. Trager
  1. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington
  1. Address correspondence to:
    William Trager, Department of Medicinal Chemistry, University of Washington, 1959 NE Pacific Street, Health Sciences Bldg., H-364C, Seattle, WA 98195-7631. E-mail: trager{at}u.washington.edu
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Research ArticleArticle

THE USE OF DEUTERIUM ISOTOPE EFFECTS TO PROBE THE ACTIVE SITE PROPERTIES, MECHANISM OF CYTOCHROME P450-CATALYZED REACTIONS, AND MECHANISMS OF METABOLICALLY DEPENDENT TOXICITY

Sidney D. Nelson and William F. Trager
Drug Metabolism and Disposition December 1, 2003, 31 (12) 1481-1497; DOI: https://doi.org/10.1124/dmd.31.12.1481
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