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PubMed
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History
- Received March 20, 2003
- Accepted June 25, 2003
- Published online November 18, 2003.
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The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Laura P. James,
- Philip R. Mayeux and
- Jack A. Hinson
- Departments of Pediatrics (L.P.J.) and Pharmacology and Toxicology (L.P.J., P.R.M., J.A.H.), University of Arkansas for Medical Sciences, Little Rock, Arkansas
- Address correspondence to:
Dr. Laura James, Department of Pediatrics, Arkansas Children's Hospital, 800 Marshall Street, Little Rock, AR 72202. E-mail: jameslaurap{at}uams.edu
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- Article
- Abstract
- Metabolic Activation of Acetaminophen
- Biochemical Mechanisms of Toxicity
- Early Research on Oxidative Stress
- Role of Kupffer Cells
- Nitrotyrosine and Acetaminophen Toxicity
- Nitration of Tyrosine versus Oxidative Stress
- Cytokines and Other Inflammatory Mediators in Acetaminophen Toxicity
- Superoxide Formation and Mitochondrial Dysfunction in Acetaminophen Toxicity
- Summary
- Footnotes
- References
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