Drug Metabolism and Disposition: 31 (3)

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Light microscopy autoradiograms showing the localizatin of [³H]DMBA adducts in [³H]DMBA-incubated (0.5 µM; 90 min) explants of dura mater (A, B, C) from a PCB 126-treated mouse and leptomeninges (D, E) and choroid plexus (F, G, H) from a PCB 126-treated rat. See the article by Granberg et al. on page 259 of this issue.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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