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Drug Metabolism & Disposition

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Table of Contents

April 01, 2003; Volume 31,Issue 4

Commentary

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    Cytochrome P450 In Vitro Reaction Phenotyping: A Re-evaluation of Approaches Used for P450 Isoform Identification
    Anthony Y. H. Lu, Regina W. Wang and Jiunn H. Lin
    Drug Metabolism and Disposition April 2003, 31 (4) 345-350; DOI: https://doi.org/10.1124/dmd.31.4.345

Short Communications

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    Direct Identification of Cytochrome P450 Isozymes by Matrix-assisted Laser Desorption/Ionization Time of Flight-Based Proteomic Approach
    Nadezhda Galeva, Dmitry Yakovlev, Yakov Koen, Tatyana Duzhak and Michail Alterman
    Drug Metabolism and Disposition April 2003, 31 (4) 351-355; DOI: https://doi.org/10.1124/dmd.31.4.351
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    Homotropic Versus Heterotopic Cooperativity of Cytochrome P450eryF: A Substrate Oxidation and Spectral Titration Study
    Kishore K. Khan, Hong Liu and James R. Halpert
    Drug Metabolism and Disposition April 2003, 31 (4) 356-359; DOI: https://doi.org/10.1124/dmd.31.4.356

Symposium Article

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    The Changing Environment of Graduate and Postdoctoral Training in Drug Metabolism: Viewpoints from Academia, Industry, and Government
    Jeffrey C. Stevens, Dennis C. Dean, Peter C. Preusch and Maria Almira Correia
    Drug Metabolism and Disposition April 2003, 31 (4) 360-366; DOI: https://doi.org/10.1124/dmd.31.4.360

Articles

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    Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin
    Osamu Ueda, Shigeyuki Kitamura, Koji Ohashi, Kazumi Sugihara and Shigeru Ohta
    Drug Metabolism and Disposition April 2003, 31 (4) 367-372; DOI: https://doi.org/10.1124/dmd.31.4.367
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    Segmental Intestinal Transporters and Metabolic Enzymes on Intestinal Drug Absorption
    Debbie Tam, Rommel G. Tirona and K. Sandy Pang
    Drug Metabolism and Disposition April 2003, 31 (4) 373-383; DOI: https://doi.org/10.1124/dmd.31.4.373
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    Inhibition and Activation of the Human Liver Microsomal and Human Cytochrome P450 3A4 Metabolism of Testosterone by Deployment-Related Chemicals
    Khawja A. Usmani, Randy L. Rose and Ernest Hodgson
    Drug Metabolism and Disposition April 2003, 31 (4) 384-391; DOI: https://doi.org/10.1124/dmd.31.4.384
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    Lipopolysaccharide-Mediated Modulation of Cytochromes P450 in Stat1 Null Mice
    Jinmei Pan, Qian Xiang, Simon Ball, JoAnn Scatina, John Kao and Jun-Yan Hong
    Drug Metabolism and Disposition April 2003, 31 (4) 392-397; DOI: https://doi.org/10.1124/dmd.31.4.392
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    Functional Characterization of Cytochrome P450 2B6 Allelic Variants
    Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Yuko Makino, Erika Matsushima, Nobumitsu Hanioka and Masanori Ando
    Drug Metabolism and Disposition April 2003, 31 (4) 398-403; DOI: https://doi.org/10.1124/dmd.31.4.398
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    Identification of the Human Liver Enzymes Involved in the Metabolism of the Antimigraine Agent Almotriptan
    Miquel Salva, Josep M. Jansat, Antonio Martinez-Tobed and Jose M. Palacios
    Drug Metabolism and Disposition April 2003, 31 (4) 404-411; DOI: https://doi.org/10.1124/dmd.31.4.404
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    Characterization of Substrate Binding to Cytochrome P450 1A1 Using Molecular Modeling and Kinetic Analyses: Case of Residue 382
    Jianguo Liu, Spencer S. Ericksen, Dan Besspiata, Charles W. Fisher and Grazyna D. Szklarz
    Drug Metabolism and Disposition April 2003, 31 (4) 412-420; DOI: https://doi.org/10.1124/dmd.31.4.412
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    Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes
    Ajay Madan, Richard A. Graham, Kathleen M. Carroll, Daniel R. Mudra, L. Alayne Burton, Linda A. Krueger, April D. Downey, Maciej Czerwinski, Jameson Forster, Maria D. Ribadeneira, Liang-Shang Gan, Edward L. LeCluyse, Karl Zech, Philmore Robertson, Patrick Koch, Lida Antonian, Greg Wagner, Li Yu and Andrew Parkinson
    Drug Metabolism and Disposition April 2003, 31 (4) 421-431; DOI: https://doi.org/10.1124/dmd.31.4.421
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    CYP3A4 and CYP3A7-Mediated Carbamazepine 10,11-Epoxidation Are Activated by Differential Endogenous Steroids
    Hiroyoshi Nakamura, Nao Torimoto, Itsuko Ishii, Noritaka Ariyoshi, Hiromitsu Nakasa, Shigeru Ohmori and Mitsukazu Kitada
    Drug Metabolism and Disposition April 2003, 31 (4) 432-438; DOI: https://doi.org/10.1124/dmd.31.4.432
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    Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition
    Jasminder Sahi, Christopher B. Black, Geraldine A. Hamilton, Xianxian Zheng, Summer Jolley, Kelly A. Rose, Darryl Gilbert, Edward L. LeCluyse and Michael W. Sinz
    Drug Metabolism and Disposition April 2003, 31 (4) 439-446; DOI: https://doi.org/10.1124/dmd.31.4.439
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    Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes
    Robert Houle, Jennifer Raoul, Jean-François Lévesque, K. Sandy Pang, Deborah A. Nicoll-Griffith and Jose M. Silva
    Drug Metabolism and Disposition April 2003, 31 (4) 447-451; DOI: https://doi.org/10.1124/dmd.31.4.447
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    Glucuronides of Tea Catechins: Enzymology of Biosynthesis and Biological Activities
    Hong Lu, Xiaofeng Meng, Chuan Li, Shengmin Sang, Christopher Patten, Shuqun Sheng, Jungil Hong, Naisheng Bai, Bozena Winnik, Chi-Tang Ho and Chung S. Yang
    Drug Metabolism and Disposition April 2003, 31 (4) 452-461; DOI: https://doi.org/10.1124/dmd.31.4.452
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    Modeling the Metabolism of Idarubicin to Idarubicinol in Rat Heart: Effect of Rutin and Phenobarbital
    Wonku Kang and Michael Weiss
    Drug Metabolism and Disposition April 2003, 31 (4) 462-468; DOI: https://doi.org/10.1124/dmd.31.4.462
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    Thalidomide-induced Suppression of Embryo Fibroblast Proliferation Requires CYP1A1-Mediated Activation
    Masaaki Miyata, Etsuko Tamura, Kazuko Motoki, Kiyoshi Nagata and Yasushi Yamazoe
    Drug Metabolism and Disposition April 2003, 31 (4) 469-475; DOI: https://doi.org/10.1124/dmd.31.4.469
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    Cytochrome P450 2C8 and Flavin-containing Monooxygenases are Involved in the Metabolism of Tazarotenic Acid in Humans
    Mayssa Attar, Dahai Dong, Kah-Hiing John Ling and Diane D-S. Tang-Liu
    Drug Metabolism and Disposition April 2003, 31 (4) 476-481; DOI: https://doi.org/10.1124/dmd.31.4.476
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    Multiple Alterations of Canalicular Membrane Transport Activities in Rats with CCl4-induced Hepatic Injury
    Im-Sook Song, Young-Mi Lee, Suk-Jae Chung and Chang-Koo Shim
    Drug Metabolism and Disposition April 2003, 31 (4) 482-490; DOI: https://doi.org/10.1124/dmd.31.4.482
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    Pharmacokinetics and Metabolism of a COX-2 Inhibitor, Valdecoxib, in Mice
    Ji Y. Zhang, Josh J. Yuan, Yue-Fen Wang, Roy H. Bible and Alan P. Breau
    Drug Metabolism and Disposition April 2003, 31 (4) 491-501; DOI: https://doi.org/10.1124/dmd.31.4.491
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    Pharmacokinetics, Metabolic Stability, and Subcutaneous Bioavailability of a Genetically Engineered Analog of DcR3, FLINT [DcR3(R218Q)], in Cynomolgus Monkeys and Mice
    Victor J. Wroblewski, Christy McCloud, Kelly Davis, Joseph Manetta, Radmila Micanovic and Derrick R. Witcher
    Drug Metabolism and Disposition April 2003, 31 (4) 502-507; DOI: https://doi.org/10.1124/dmd.31.4.502
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Drug Metabolism and Disposition: 31 (4)
Drug Metabolism and Disposition
Vol. 31, Issue 4
1 Apr 2003
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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