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Drug Metabolism & Disposition

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Table of Contents

May 01, 2003; Volume 31,Issue 5

Editorial

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    Editorial
    James R. Halpert
    Drug Metabolism and Disposition May 2003, 31 (5) 509; DOI: https://doi.org/10.1124/dmd.31.5.509

MINIREVIEW

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    Diversity of Mechanism-Based Pharmacodynamic Models
    Donald E. Mager, Elzbieta Wyska and William J. Jusko
    Drug Metabolism and Disposition May 2003, 31 (5) 510-518; DOI: https://doi.org/10.1124/dmd.31.5.510

Short Communications

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    Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers
    Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Robin M. Taylor and John S. Markowitz
    Drug Metabolism and Disposition May 2003, 31 (5) 519-522; DOI: https://doi.org/10.1124/dmd.31.5.519
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    Regulation of Drug Transporter Gene Expression by Nuclear Receptors
    Jeff L. Staudinger, Ajay Madan, Kathleen M. Carol and Andrew Parkinson
    Drug Metabolism and Disposition May 2003, 31 (5) 523-527; DOI: https://doi.org/10.1124/dmd.31.5.523

Articles

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    Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10
    Hideto Jinno, Mayumi Saeki, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Yoshiro Saito, Shogo Ozawa, Masanori Ando, Kuniaki Shirao, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo and Jun-ichi Sawada
    Drug Metabolism and Disposition May 2003, 31 (5) 528-532; DOI: https://doi.org/10.1124/dmd.31.5.528
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    Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products
    Judy L. Raucy
    Drug Metabolism and Disposition May 2003, 31 (5) 533-539; DOI: https://doi.org/10.1124/dmd.31.5.533
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    Identification of the Cytochrome P450 Enzymes Involved in the N-Oxidation of Voriconazole
    R. Hyland, B. C. Jones and D. A. Smith
    Drug Metabolism and Disposition May 2003, 31 (5) 540-547; DOI: https://doi.org/10.1124/dmd.31.5.540
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    Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam
    Camille P. Granvil, Ai-Ming Yu, Guillermo Elizondo, Taro E. Akiyama, Connie Cheung, Lionel Feigenbaum, Kristopher W. Krausz and Frank J. Gonzalez
    Drug Metabolism and Disposition May 2003, 31 (5) 548-558; DOI: https://doi.org/10.1124/dmd.31.5.548
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    Endocrine Regulation of Rat Organic Anion Transporters
    Susan C. N. Buist, Nathan J. Cherrington and Curtis D. Klaassen
    Drug Metabolism and Disposition May 2003, 31 (5) 559-564; DOI: https://doi.org/10.1124/dmd.31.5.559
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    Comparison of In Vitro and In Vivo Inhibition Potencies of Fluvoxamine toward CYP2C19
    Caiping Yao, Kent L. Kunze, William F. Trager, Evan D. Kharasch and René H. Levy
    Drug Metabolism and Disposition May 2003, 31 (5) 565-571; DOI: https://doi.org/10.1124/dmd.31.5.565
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    Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate
    Hong Lu, Xiaofeng Meng and Chung S. Yang
    Drug Metabolism and Disposition May 2003, 31 (5) 572-579; DOI: https://doi.org/10.1124/dmd.31.5.572
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    Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro
    Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama and Yuichi Sugiyama
    Drug Metabolism and Disposition May 2003, 31 (5) 580-588; DOI: https://doi.org/10.1124/dmd.31.5.580
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    Glucuronidation of Etoposide in Human Liver Microsomes Is Specifically Catalyzed by UDP-Glucuronosyltransferase 1A1
    Yuichiro Watanabe, Miki Nakajima, Noriko Ohashi, Toshiyuki Kume and Tsuyoshi Yokoi
    Drug Metabolism and Disposition May 2003, 31 (5) 589-595; DOI: https://doi.org/10.1124/dmd.31.5.589
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    Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6
    Amit S. Kalgutkar, Sue Zhou, Odette A. Fahmi and Timothy J. Taylor
    Drug Metabolism and Disposition May 2003, 31 (5) 596-605; DOI: https://doi.org/10.1124/dmd.31.5.596
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    Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions
    Jeannine M. Margolis and R. Scott Obach
    Drug Metabolism and Disposition May 2003, 31 (5) 606-611; DOI: https://doi.org/10.1124/dmd.31.5.606
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    Constitutive and Inducible Hepatic Cytochrome P450 Isoforms in Senescent Male and Female Rats and Response to Low-Dose Phenobarbital
    Arun K. Agrawal and Bernard H. Shapiro
    Drug Metabolism and Disposition May 2003, 31 (5) 612-619; DOI: https://doi.org/10.1124/dmd.31.5.612
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    Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes
    Hongbing Wang, Stephanie R. Faucette, Darryl Gilbert, Summer L. Jolley, Tatsuya Sueyoshi, Masahiko Negishi and Edward L. LeCluyse
    Drug Metabolism and Disposition May 2003, 31 (5) 620-630; DOI: https://doi.org/10.1124/dmd.31.5.620
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    Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes
    Balázs Dalmadi, János Leibinger, Szabolcs Szeberényi, Tı́mea Borbás, Sándor Farkas, Zsolt Szombathelyi and Károly Tihanyi
    Drug Metabolism and Disposition May 2003, 31 (5) 631-636; DOI: https://doi.org/10.1124/dmd.31.5.631
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    Tamoxifen Induction of Aryl Sulfotransferase and Hydroxysteroid Sulfotransferase in Male and Female Rat Liver and Intestine
    Smarajit Maiti and Guangping Chen
    Drug Metabolism and Disposition May 2003, 31 (5) 637-644; DOI: https://doi.org/10.1124/dmd.31.5.637
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    Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug
    Bernd Clement and Katrin Lopian
    Drug Metabolism and Disposition May 2003, 31 (5) 645-651; DOI: https://doi.org/10.1124/dmd.31.5.645
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    Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism
    Ji Y. Zhang, Jenny Zhan, Chyung S. Cook, Robert M. Ings and Alan P. Breau
    Drug Metabolism and Disposition May 2003, 31 (5) 652-658; DOI: https://doi.org/10.1124/dmd.31.5.652
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    Toxicokinetics and Metabolism ofN-[14C]N-Methyl-2-Pyrrolidone in Male Sprague-Dawley Rats: in Vivo and in Vitro Percutaneous Absorption
    Jean-Paul Payan, Isabelle Boudry, Dominique Beydon, Jean-Paul Fabry, Marie-Christine Grandclaude, Elisabeth Ferrari and Jean-Claude André
    Drug Metabolism and Disposition May 2003, 31 (5) 659-669; DOI: https://doi.org/10.1124/dmd.31.5.659
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    Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics
    David Turgeon, Jean-Sébastien Carrier, Sarah Chouinard and Alain Bélanger
    Drug Metabolism and Disposition May 2003, 31 (5) 670-676; DOI: https://doi.org/10.1124/dmd.31.5.670
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    Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy
    Takeshi Hirota, Ichiro Ieiri, Hiroshi Takane, Hiroyuki Sano, Katsuyuki Kawamoto, Hironao Aono, Akira Yamasaki, Hiromi Takeuchi, Mikio Masada, Eiji Shimizu, Shun Higuchi and Kenji Otsubo
    Drug Metabolism and Disposition May 2003, 31 (5) 677-680; DOI: https://doi.org/10.1124/dmd.31.5.677

Accelerated Communication

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    Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor
    Srikanth C. Nallani, Bryan Goodwin, Jodi M. Maglich, Donna J. Buckley, Arthur R. Buckley and Pankaj B. Desai
    Drug Metabolism and Disposition May 2003, 31 (5) 681-684; DOI: https://doi.org/10.1124/dmd.31.5.681

Letters to the Editor

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    Quantitation of CYP2B6, Constitutive Androstane Receptor, and Pregnane X Receptor mRNA levels
    Leah M. Hesse and Michael H. Court
    Drug Metabolism and Disposition May 2003, 31 (5) 685; DOI: https://doi.org/10.1124/dmd.31.5.685
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    Response to Letter to the Editor
    Thomas K. H. Chang, Stelvio M. Bandiera and Jie Chen
    Drug Metabolism and Disposition May 2003, 31 (5) 686; DOI: https://doi.org/10.1124/dmd.31.5.686
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Drug Metabolism and Disposition: 31 (5)
Drug Metabolism and Disposition
Vol. 31, Issue 5
1 May 2003
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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