Table of Contents

Articles

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  Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10

  Hideto Jinno, Mayumi Saeki, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Yoshiro Saito, Shogo Ozawa, Masanori Ando, Kuniaki Shirao, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo and Jun-ichi Sawada

  Drug Metabolism and Disposition May 2003, 31 (5) 528-532; DOI: https://doi.org/10.1124/dmd.31.5.528
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  Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products

  Judy L. Raucy

  Drug Metabolism and Disposition May 2003, 31 (5) 533-539; DOI: https://doi.org/10.1124/dmd.31.5.533
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  Identification of the Cytochrome P450 Enzymes Involved in the N-Oxidation of Voriconazole

  R. Hyland, B. C. Jones and D. A. Smith

  Drug Metabolism and Disposition May 2003, 31 (5) 540-547; DOI: https://doi.org/10.1124/dmd.31.5.540
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  Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

  Camille P. Granvil, Ai-Ming Yu, Guillermo Elizondo, Taro E. Akiyama, Connie Cheung, Lionel Feigenbaum, Kristopher W. Krausz and Frank J. Gonzalez

  Drug Metabolism and Disposition May 2003, 31 (5) 548-558; DOI: https://doi.org/10.1124/dmd.31.5.548
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  Endocrine Regulation of Rat Organic Anion Transporters

  Susan C. N. Buist, Nathan J. Cherrington and Curtis D. Klaassen

  Drug Metabolism and Disposition May 2003, 31 (5) 559-564; DOI: https://doi.org/10.1124/dmd.31.5.559
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  Comparison of In Vitro and In Vivo Inhibition Potencies of Fluvoxamine toward CYP2C19

  Caiping Yao, Kent L. Kunze, William F. Trager, Evan D. Kharasch and René H. Levy

  Drug Metabolism and Disposition May 2003, 31 (5) 565-571; DOI: https://doi.org/10.1124/dmd.31.5.565
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  Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate

  Hong Lu, Xiaofeng Meng and Chung S. Yang

  Drug Metabolism and Disposition May 2003, 31 (5) 572-579; DOI: https://doi.org/10.1124/dmd.31.5.572
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  Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

  Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama and Yuichi Sugiyama

  Drug Metabolism and Disposition May 2003, 31 (5) 580-588; DOI: https://doi.org/10.1124/dmd.31.5.580
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  Glucuronidation of Etoposide in Human Liver Microsomes Is Specifically Catalyzed by UDP-Glucuronosyltransferase 1A1

  Yuichiro Watanabe, Miki Nakajima, Noriko Ohashi, Toshiyuki Kume and Tsuyoshi Yokoi

  Drug Metabolism and Disposition May 2003, 31 (5) 589-595; DOI: https://doi.org/10.1124/dmd.31.5.589
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  Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6

  Amit S. Kalgutkar, Sue Zhou, Odette A. Fahmi and Timothy J. Taylor

  Drug Metabolism and Disposition May 2003, 31 (5) 596-605; DOI: https://doi.org/10.1124/dmd.31.5.596
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  Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

  Jeannine M. Margolis and R. Scott Obach

  Drug Metabolism and Disposition May 2003, 31 (5) 606-611; DOI: https://doi.org/10.1124/dmd.31.5.606
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  Constitutive and Inducible Hepatic Cytochrome P450 Isoforms in Senescent Male and Female Rats and Response to Low-Dose Phenobarbital

  Arun K. Agrawal and Bernard H. Shapiro

  Drug Metabolism and Disposition May 2003, 31 (5) 612-619; DOI: https://doi.org/10.1124/dmd.31.5.612
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  Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes

  Hongbing Wang, Stephanie R. Faucette, Darryl Gilbert, Summer L. Jolley, Tatsuya Sueyoshi, Masahiko Negishi and Edward L. LeCluyse

  Drug Metabolism and Disposition May 2003, 31 (5) 620-630; DOI: https://doi.org/10.1124/dmd.31.5.620
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  Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes

  Balázs Dalmadi, János Leibinger, Szabolcs Szeberényi, Tı́mea Borbás, Sándor Farkas, Zsolt Szombathelyi and Károly Tihanyi

  Drug Metabolism and Disposition May 2003, 31 (5) 631-636; DOI: https://doi.org/10.1124/dmd.31.5.631
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  Tamoxifen Induction of Aryl Sulfotransferase and Hydroxysteroid Sulfotransferase in Male and Female Rat Liver and Intestine

  Smarajit Maiti and Guangping Chen

  Drug Metabolism and Disposition May 2003, 31 (5) 637-644; DOI: https://doi.org/10.1124/dmd.31.5.637
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  Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

  Bernd Clement and Katrin Lopian

  Drug Metabolism and Disposition May 2003, 31 (5) 645-651; DOI: https://doi.org/10.1124/dmd.31.5.645
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  Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism

  Ji Y. Zhang, Jenny Zhan, Chyung S. Cook, Robert M. Ings and Alan P. Breau

  Drug Metabolism and Disposition May 2003, 31 (5) 652-658; DOI: https://doi.org/10.1124/dmd.31.5.652
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  Toxicokinetics and Metabolism ofN-[¹⁴C]N-Methyl-2-Pyrrolidone in Male Sprague-Dawley Rats: in Vivo and in Vitro Percutaneous Absorption

  Jean-Paul Payan, Isabelle Boudry, Dominique Beydon, Jean-Paul Fabry, Marie-Christine Grandclaude, Elisabeth Ferrari and Jean-Claude André

  Drug Metabolism and Disposition May 2003, 31 (5) 659-669; DOI: https://doi.org/10.1124/dmd.31.5.659
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  Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics

  David Turgeon, Jean-Sébastien Carrier, Sarah Chouinard and Alain Bélanger

  Drug Metabolism and Disposition May 2003, 31 (5) 670-676; DOI: https://doi.org/10.1124/dmd.31.5.670
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  Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

  Takeshi Hirota, Ichiro Ieiri, Hiroshi Takane, Hiroyuki Sano, Katsuyuki Kawamoto, Hironao Aono, Akira Yamasaki, Hiromi Takeuchi, Mikio Masada, Eiji Shimizu, Shun Higuchi and Kenji Otsubo

  Drug Metabolism and Disposition May 2003, 31 (5) 677-680; DOI: https://doi.org/10.1124/dmd.31.5.677