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Rapid CommunicationShort Communication

Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers

Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Robin M. Taylor and John S. Markowitz
Drug Metabolism and Disposition May 2003, 31 (5) 519-522; DOI: https://doi.org/10.1124/dmd.31.5.519
Jennifer L. Donovan
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C. Lindsay DeVane
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Kenneth D. Chavin
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Robin M. Taylor
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John S. Markowitz
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Abstract

Siberian ginseng ([SG]; Eleutherococcus senticosus) is a commonly used herbal preparation. The objective of this study was to assess in normal volunteers (n = 12) the influence of a standardized SG extract on the activity of cytochrome P450 CYP2D6 and 3A4. Probe substrates dextromethorphan (CYP2D6 activity) and alprazolam (CYP3A4 activity) were administered orally at baseline and again following treatment with SG (1 × 485 mg twice daily) for 14 days. Urinary concentrations of dextromethorphan and dextorphan were quantified, and dextromethorphan metabolic ratios (DMRs) were determined at baseline and after SG treatment. Likewise, plasma samples were collected (0–60 h) for alprazolam pharmacokinetics at baseline and after SG treatment to assess effects on CYP3A4 activity. Validated high performance liquid chromatography methods were used to quantify all compounds and relevant metabolites. There were no statistically significant differences between pre- and post-SG treatment DMRs indicating a lack of effect on CYP2D6 (P > 0.05). For alprazolam there also were no significant differences in the pharmacokinetic parameters determined by noncompartmental modeling (Cmax, Tmax, area under the curve, half-life of elimination) indicating that SG does not significantly induce or inhibit CYP3A4 (P > 0.05). Our results indicate that standardized extracts of SG at generally recommended doses for over-the-counter use are unlikely to alter the disposition of coadministered medications primarily dependent on the CYP2D6 or CYP3A4 pathways for elimination.

Footnotes

  • This study was sponsored by Public Health Service Grant NCCAM R21 AT00511−01.

  • Abbreviations used are::
    SG
    Siberian ginseng
    DM
    dextromethorphan
    ALPZ
    alprazolam
    DMR
    dextromethorphan metabolic ratio
    • Received December 10, 2002.
    • Accepted January 17, 2003.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 31 (5)
Drug Metabolism and Disposition
Vol. 31, Issue 5
1 May 2003
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Rapid CommunicationShort Communication

Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers

Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Robin M. Taylor and John S. Markowitz
Drug Metabolism and Disposition May 1, 2003, 31 (5) 519-522; DOI: https://doi.org/10.1124/dmd.31.5.519

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Rapid CommunicationShort Communication

Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers

Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Robin M. Taylor and John S. Markowitz
Drug Metabolism and Disposition May 1, 2003, 31 (5) 519-522; DOI: https://doi.org/10.1124/dmd.31.5.519
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