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Research ArticleArticle

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama and Yuichi Sugiyama
Drug Metabolism and Disposition May 2003, 31 (5) 580-588; DOI: https://doi.org/10.1124/dmd.31.5.580

Article Information

vol. 31 no. 5 580-588
DOI 
https://doi.org/10.1124/dmd.31.5.580
PubMed 
12695346
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 10, 2002
  • Accepted February 4, 2003
  • Published online May 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoichi Naritomi1,
  2. Shigeyuki Terashita1,
  3. Akira Kagayama1 and
  4. Yuichi Sugiyama2
  1. 1Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan (Y.N., S.T., A.K.); and 2Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan (Y.S.)
  1. Yoichi Naritomi, Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka 532-8514, Japan. E-mail: yoichi-naritomi{at}po.fujisawa.co.jp
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Research ArticleArticle

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama and Yuichi Sugiyama
Drug Metabolism and Disposition May 1, 2003, 31 (5) 580-588; DOI: https://doi.org/10.1124/dmd.31.5.580
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