Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

	Abstract	Full	Pdf
Apr 2003	88	45	178
May 2003	75	122	159
Jun 2003	12	36	69
Jul 2003	21	28	50
Aug 2003	9	17	33
Sep 2003	13	23	29
Oct 2003	15	31	27
Nov 2003	15	30	33
Dec 2003	14	26	19
Jan 2004	11	25	40
Feb 2004	12	36	23
Mar 2004	12	39	40
Apr 2004	11	26	22
May 2004	48	35	66
Jun 2004	21	35	38
Jul 2004	12	31	60
Aug 2004	22	36	32
Sep 2004	40	62	31
Oct 2004	24	58	27
Nov 2004	24	49	29
Dec 2004	27	48	25
Jan 2005	30	43	37
Feb 2005	19	38	25
Mar 2005	16	52	49
Apr 2005	4	36	28
May 2005	5	25	30
Jun 2005	8	28	40
Jul 2005	12	25	24
Aug 2005	6	28	24
Sep 2005	16	52	33
Oct 2005	10	27	25
Nov 2005	13	27	35
Dec 2005	6	19	16
Jan 2006	5	40	19
Feb 2006	11	43	21
Mar 2006	10	25	16
Apr 2006	7	24	24
May 2006	7	20	16
Jun 2006	8	18	16
Jul 2006	10	10	17
Aug 2006	15	17	23
Sep 2006	7	29	18
Oct 2006	6	31	21
Nov 2006	9	26	24
Dec 2006	8	13	9
Jan 2007	12	36	28
Feb 2007	11	21	14
Mar 2007	7	16	20
Apr 2007	6	26	16
May 2007	6	31	19
Jun 2007	8	28	17
Jul 2007	12	21	20
Aug 2007	14	20	21
Sep 2007	7	12	11
Oct 2007	15	18	16
Nov 2007	9	12	18
Dec 2007	11	7	11
Jan 2008	5	6	10
Feb 2008	9	16	16
Mar 2008	3	13	16
Apr 2008	11	9	12
May 2008	7	15	15
Jun 2008	4	16	10
Jul 2008	16	17	18
Aug 2008	11	13	10
Sep 2008	22	28	15
Oct 2008	17	23	19
Nov 2008	8	13	18
Dec 2008	11	11	12
Jan 2009	8	12	15
Feb 2009	10	14	20
Mar 2009	8	17	9
Apr 2009	4	12	16
May 2009	5	7	8
Jun 2009	6	9	11
Jul 2009	4	10	13
Aug 2009	10	14	21
Sep 2009	10	17	13
Oct 2009	21	10	11
Nov 2009	16	12	15
Dec 2009	12	16	14
Jan 2010	15	6	13
Feb 2010	14	6	8
Mar 2010	14	7	11
Apr 2010	9	12	10
May 2010	7	13	10
Jun 2010	6	16	9
Jul 2010	12	15	12
Aug 2010	5	13	7
Sep 2010	15	17	10
Oct 2010	7	15	5
Nov 2010	10	20	13
Dec 2010	15	10	7
Jan 2011	12	15	13
Feb 2011	9	15	11
Mar 2011	20	17	12
Apr 2011	9	9	9
May 2011	11	8	1
Jun 2011	11	10	6
Jul 2011	18	16	16
Aug 2011	15	13	18
Sep 2011	12	9	7
Oct 2011	9	13	9
Nov 2011	15	7	11
Dec 2011	15	14	11
Jan 2012	7	14	17
Feb 2012	17	13	16
Mar 2012	15	10	18
Apr 2012	11	8	16
May 2012	18	8	12
Jun 2012	13	14	11
Jul 2012	9	6	9
Aug 2012	10	8	11
Sep 2012	13	10	13
Oct 2012	21	14	14
Nov 2012	7	14	13
Dec 2012	5	10	8
Jan 2013	17	13	21
Feb 2013	12	6	10
Mar 2013	12	6	7
Apr 2013	13	9	15
May 2013	16	8	6
Jun 2013	11	3	7
Jul 2013	11	5	6
Aug 2013	5	10	4
Sep 2013	15	5	8
Oct 2013	10	6	13
Nov 2013	7	8	2
Dec 2013	8	3	10
Jan 2014	6	1	4
Feb 2014	11	7	11
Mar 2014	14	4	8
Apr 2014	16	12	9
May 2014	8	9	9
Jun 2014	8	6	9
Jul 2014	23	7	12
Aug 2014	8	9	15
Sep 2014	11	9	17
Oct 2014	13	7	17
Nov 2014	14	6	16
Dec 2014	14	11	11
Jan 2015	6	6	19
Feb 2015	6	8	6
Mar 2015	8	8	13
Apr 2015	4	5	7
May 2015	12	5	9
Jun 2015	14	7	18
Jul 2015	18	16	14
Aug 2015	12	5	6
Sep 2015	12	7	8
Oct 2015	4	13	8
Nov 2015	3	4	10
Dec 2015	11	2	6
Jan 2016	10	5	13
Feb 2016	2	3	8
Mar 2016	6	3	23
Apr 2016	9	5	21
May 2016	1	11	19
Jun 2016	3	2	8
Jul 2016	8	7	12
Aug 2016	4	4	5
Sep 2016	9	8	9
Oct 2016	1	19	9
Nov 2016	3	18	12
Dec 2016	1	12	7
Jan 2017	1	31	11
Feb 2017	0	8	4
Mar 2017	1	10	3
Apr 2017	1	16	5
May 2017	1	18	12
Jun 2017	1	9	7
Jul 2017	1	14	7
Aug 2017	1	30	17
Sep 2017	0	45	11
Oct 2017	1	79	5
Nov 2017	4	30	7
Dec 2017	1	10	7
Jan 2018	0	17	7
Feb 2018	2	11	7
Mar 2018	1	33	9
Apr 2018	0	17	12
May 2018	5	27	13
Jun 2018	1	17	5
Jul 2018	0	16	16
Aug 2018	1	13	4
Sep 2018	0	21	3
Oct 2018	2	32	16
Nov 2018	0	27	10
Dec 2018	19	11	13
Jan 2019	13	3	3
Feb 2019	44	1	3
Mar 2019	18	5	3
Apr 2019	5	2	0
May 2019	9	3	0
Jun 2019	7	0	2
Jul 2019	36	0	2
Aug 2019	23	1	2
Sep 2019	40	6	2
Oct 2019	19	1	2
Nov 2019	20	3	10
Dec 2019	35	12	1
Jan 2020	20	9	3
Feb 2020	14	4	3
Mar 2020	4	11	6
Apr 2020	36	1	1
May 2020	15	3	3
Jun 2020	25	2	1
Jul 2020	7	2	2
Aug 2020	4	8	6
Sep 2020	31	15	5
Oct 2020	20	23	2
Nov 2020	12	13	0
Dec 2020	8	7	3
Jan 2021	7	30	2
Feb 2021	11	42	0