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Research ArticleArticle

Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

Jeannine M. Margolis and R. Scott Obach
Drug Metabolism and Disposition May 2003, 31 (5) 606-611; DOI: https://doi.org/10.1124/dmd.31.5.606

Article Information

vol. 31 no. 5 606-611
DOI 
https://doi.org/10.1124/dmd.31.5.606
PubMed 
12695349
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 15, 2002
  • Accepted February 3, 2003
  • Published online May 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jeannine M. Margolis and
  2. R. Scott Obach
  1. Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut
  1. Dr. R. Scott Obach, MS 4088, Pfizer Global Research and Development, Groton, CT 06340. E-mail:obachrs{at}groton.pfizer.com
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Research ArticleArticle

Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

Jeannine M. Margolis and R. Scott Obach
Drug Metabolism and Disposition May 1, 2003, 31 (5) 606-611; DOI: https://doi.org/10.1124/dmd.31.5.606
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