Table of Contents

Articles

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  HIGH PRESSURE LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY CHARACTERIZATION OF THE NEPHROTOXIC BIOTRANSFORMATION PRODUCTS OF CISPLATIN

  Danyelle M. Townsend, Jarrod A. Marto, Mei Deng, Timothy J. Macdonald and Marie H. Hanigan

  Drug Metabolism and Disposition June 2003, 31 (6) 705-713; DOI: https://doi.org/10.1124/dmd.31.6.705
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  INFLUENCE OF PROPIVERINE ON HEPATIC MICROSOMAL CYTOCHROME P450 ENZYMES IN MALE RATS

  R. Walter, C. Ullmann, D. Thümmler and W. Siegmund

  Drug Metabolism and Disposition June 2003, 31 (6) 714-717; DOI: https://doi.org/10.1124/dmd.31.6.714
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  DISTINCT TISSUE DISTRIBUTION OF METABOLITES OF THE NOVEL GLUTATHIONE-ACTIVATED THIOPURINE PRODRUGS CIS-6-(2-ACETYLVINYLTHIO)PURINE AND TRANS-6-(2-ACETYLVINYLTHIO)GUANINE AND 6-THIOGUANINE IN THE MOUSE

  Sjofn Gunnarsdottir and Adnan A. Elfarra

  Drug Metabolism and Disposition June 2003, 31 (6) 718-726; DOI: https://doi.org/10.1124/dmd.31.6.718
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  COVALENT BINDING OF 2-PHENYLPROPIONYL-S-ACYL-COA THIOESTER TO TISSUE PROTEINS IN VITRO

  Chunze Li, Mobolaji O. Olurinde, Laura M. Hodges, Mark P. Grillo and Leslie Z. Benet

  Drug Metabolism and Disposition June 2003, 31 (6) 727-730; DOI: https://doi.org/10.1124/dmd.31.6.727
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  THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN

  S. J. Roffey, S. Cole, P. Comby, D. Gibson, S. G. Jezequel, A. N. R. Nedderman, D. A. Smith, D. K. Walker and N. Wood

  Drug Metabolism and Disposition June 2003, 31 (6) 731-741; DOI: https://doi.org/10.1124/dmd.31.6.731
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  INVOLVEMENT OF CYP3A4, CYP2C8, AND CYP2D6 IN THE METABOLISM OF (R)- AND (S)-METHADONE IN VITRO

  Jun-Sheng Wang and C. Lindsay DeVane

  Drug Metabolism and Disposition June 2003, 31 (6) 742-747; DOI: https://doi.org/10.1124/dmd.31.6.742
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  IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION

  Denis Projean, Bruno Baune, Robert Farinotti, Jean-Pierre Flinois, Philippe Beaune, Anne-Marie Taburet and Julie Ducharme

  Drug Metabolism and Disposition June 2003, 31 (6) 748-754; DOI: https://doi.org/10.1124/dmd.31.6.748
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  COMPARATIVE ANALYSIS OF CYP3A EXPRESSION IN HUMAN LIVER SUGGESTS ONLY A MINOR ROLE FOR CYP3A5 IN DRUG METABOLISM

  Anna Westlind-Johnsson, Sarah Malmebo, Anna Johansson, Charlotta Otter, Tommy B. Andersson, Inger Johansson, Robert J. Edwards, Alan R. Boobis and Magnus Ingelman-Sundberg

  Drug Metabolism and Disposition June 2003, 31 (6) 755-761; DOI: https://doi.org/10.1124/dmd.31.6.755
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  THE EFFECT OF INCUBATION CONDITIONS ON THE ENZYME KINETICS OF UDP-GLUCURONOSYLTRANSFERASES

  Matthew G. Soars, Barbara J. Ring and Steven A. Wrighton

  Drug Metabolism and Disposition June 2003, 31 (6) 762-767; DOI: https://doi.org/10.1124/dmd.31.6.762
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  INTERACTION OF BUPRENORPHINE AND ITS METABOLITE NORBUPRENORPHINE WITH CYTOCHROMES P450 IN VITRO

  Wenjiang Zhang, Yamini Ramamoorthy, Rachel F. Tyndale and Edward M. Sellers

  Drug Metabolism and Disposition June 2003, 31 (6) 768-772; DOI: https://doi.org/10.1124/dmd.31.6.768
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  INDUCTION OF HEPATIC PHASE II DRUG-METABOLIZING ENZYMES BY 1,7-PHENANTHROLINE IN RATS IS ACCOMPANIED BY INDUCTION OF MRP3

  Sui Wang, Dylan P. Hartley, Suzanne L. Ciccotto, Stella H. Vincent, Ronald B. Franklin and Mi-Sook Kim

  Drug Metabolism and Disposition June 2003, 31 (6) 773-775; DOI: https://doi.org/10.1124/dmd.31.6.773
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  EFFECTS OF ACUTE RENAL FAILURE ON THE PHARMACOKINETICS OF CHLORZOXAZONE IN RATS

  Young Jin Moon, Ae Kyung Lee, Hye Chin Chung, Eun Jung Kim, So Hee Kim, Duk Chul Lee, Inchul Lee, Sang Geon Kim and Myung Gull Lee

  Drug Metabolism and Disposition June 2003, 31 (6) 776-784; DOI: https://doi.org/10.1124/dmd.31.6.776
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  BRAIN PENETRATION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN FERRETS

  Su-Er W. Huskey, Brian J. Dean, Ray Bakhtiar, Rosa I. Sanchez, F. David Tattersall, Wayne Rycroft, Richard Hargreaves, Alan P. Watt, Gary G. Chicchi, Carolann Keohane, Donald F. Hora and Shuet-Hing L. Chiu

  Drug Metabolism and Disposition June 2003, 31 (6) 785-791; DOI: https://doi.org/10.1124/dmd.31.6.785
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  IDENTIFICATION OF THE METABOLITES OF 9-NITRO-20(S)-CAMPTOTHECIN IN RATS

  Ke Li, Xiaoyan Chen, Dafang Zhong and Yan Li

  Drug Metabolism and Disposition June 2003, 31 (6) 792-797; DOI: https://doi.org/10.1124/dmd.31.6.792
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  HEPATOBILIARY EXCRETION OF ACETAMINOPHEN GLUTATHIONE CONJUGATE AND ITS DERIVATIVES IN TRANSPORT-DEFICIENT (TR^-) HYPERBILIRUBINEMIC RATS

  Chuan Chen, Gayle E. Hennig and José E. Manautou

  Drug Metabolism and Disposition June 2003, 31 (6) 798-804; DOI: https://doi.org/10.1124/dmd.31.6.798
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  ABSORPTION/METABOLISM OF SULFORAPHANE AND QUERCETIN, AND REGULATION OF PHASE II ENZYMES, IN HUMAN JEJUNUM IN VIVO

  Niclas Petri, Christer Tannergren, Birgit Holst, Fred A. Mellon, Yongping Bao, Geoff W. Plumb, Jim Bacon, Karen A. O'Leary, Paul A. Kroon, Lars Knutson, Patrik Forsell, Thomas Eriksson, Hans Lennernas and Gary Williamson

  Drug Metabolism and Disposition June 2003, 31 (6) 805-813; DOI: https://doi.org/10.1124/dmd.31.6.805