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Drug Metabolism & Disposition

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Table of Contents

July 01, 2003; Volume 31,Issue 7

Perspective

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    THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE
    Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh and Steven A. Wrighton
    Drug Metabolism and Disposition July 2003, 31 (7) 815-832; DOI: https://doi.org/10.1124/dmd.31.7.815

Short Communication

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    SELECTIVITIES OF HUMAN CYTOCHROME P450 INHIBITORS TOWARD RAT P450 ISOFORMS: STUDY WITH cDNA-EXPRESSED SYSTEMS OF THE RAT
    Kaoru Kobayashi, Kikuko Urashima, Noriaki Shimada and Kan Chiba
    Drug Metabolism and Disposition July 2003, 31 (7) 833-836; DOI: https://doi.org/10.1124/dmd.31.7.833

Articles

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    PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS
    Donglu Zhang, Marc Ogan, Richard Gedamke, Vikram Roongta, Renke Dai, Mingshe Zhu, J. Kent Rinehart, Lewis Klunk and James Mitroka
    Drug Metabolism and Disposition July 2003, 31 (7) 837-845; DOI: https://doi.org/10.1124/dmd.31.7.837
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    IN VITRO METABOLISM OF THE MAMMALIAN SOLUBLE EPOXIDE HYDROLASE INHIBITOR, 1-CYCLOHEXYL-3-DODECYL-UREA
    Takaho Watanabe, Christophe Morisseau, John W. Newman and Bruce D. Hammock
    Drug Metabolism and Disposition July 2003, 31 (7) 846-853; DOI: https://doi.org/10.1124/dmd.31.7.846
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    TWO NEW POLYMORPHISMS OF THE FMO3 GENE IN CAUCASIAN AND AFRICAN-AMERICAN POPULATIONS: COMPARATIVE GENETIC AND FUNCTIONAL STUDIES
    Virginie Lattard, Jun Zhang, Quyen Tran, Bjarte Furnes, Daniel Schlenk and John R. Cashman
    Drug Metabolism and Disposition July 2003, 31 (7) 854-860; DOI: https://doi.org/10.1124/dmd.31.7.854
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    ELETRIPTAN METABOLISM BY HUMAN HEPATIC CYP450 ENZYMES AND TRANSPORT BY HUMAN P-GLYCOPROTEIN
    David C. Evans, Desmond O'Connor, Brian G. Lake, Raymond Evers, Christopher Allen and Richard Hargreaves
    Drug Metabolism and Disposition July 2003, 31 (7) 861-869; DOI: https://doi.org/10.1124/dmd.31.7.861
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    CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR-α CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS
    Timothy K. Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J. Beaudet, Summer Jolley, Thomas A. Brodie, Robert C. Andrews, J. David Becherer, Darryl L. McDougald, Michael D. Gaul, Debie J. Hoivik, Kathy Mellon-Kusibab, Jurgen Lehmann, Steven Kliewer, Steven Novick, Ron Laethem, Zhiyang Zhao and Edward L. LeCluyse
    Drug Metabolism and Disposition July 2003, 31 (7) 870-877; DOI: https://doi.org/10.1124/dmd.31.7.870
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    IN VITRO METABOLISM OF CLINDAMYCIN IN HUMAN LIVER AND INTESTINAL MICROSOMES
    Michael A. Wynalda, J. Matthew Hutzler, Michael D. Koets, Terry Podoll and Larry C. Wienkers
    Drug Metabolism and Disposition July 2003, 31 (7) 878-887; DOI: https://doi.org/10.1124/dmd.31.7.878
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    VERAPAMIL: METABOLISM IN CULTURES OF PRIMARY HUMAN CORONARY ARTERIAL ENDOTHELIAL CELLS
    Jürgen Borlak, Markus Walles, Karsten Levsen and Thomas Thum
    Drug Metabolism and Disposition July 2003, 31 (7) 888-891; DOI: https://doi.org/10.1124/dmd.31.7.888
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    COMPARATIVE DISPOSITION OF (R)-(+)-PULEGONE IN B6C3F1 MICE AND F344 RATS
    L.-J. Chen, E. H. Lebetkin and L. T. Burka
    Drug Metabolism and Disposition July 2003, 31 (7) 892-899; DOI: https://doi.org/10.1124/dmd.31.7.892
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    DECABROMODIPHENYL ETHER IN THE RAT: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
    Anna Mörck, Heldur Hakk, Ulrika Örn and Eva Klasson Wehler
    Drug Metabolism and Disposition July 2003, 31 (7) 900-907; DOI: https://doi.org/10.1124/dmd.31.7.900
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    NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16α-CARBONITRILE
    Chuan Chen, Jeff L. Staudinger and Curtis D. Klaassen
    Drug Metabolism and Disposition July 2003, 31 (7) 908-915; DOI: https://doi.org/10.1124/dmd.31.7.908
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    KINETIC STUDY ON THE REACTION OF CISPLATIN WITH METALLOTHIONEIN
    Douglas Hagrman, Jerry Goodisman, James C. Dabrowiak and Abdul-Kader Souid
    Drug Metabolism and Disposition July 2003, 31 (7) 916-923; DOI: https://doi.org/10.1124/dmd.31.7.916
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    IDENTIFICATION OF CYP1A2 AS THE MAIN ISOFORM FOR THE PHASE I HYDROXYLATED METABOLISM OF GENISTEIN AND A PRODRUG CONVERTING ENZYME OF METHYLATED ISOFLAVONES
    Ming Hu, Kristopher Krausz, Jun Chen, Xia Ge, Jianqi Li, Harry L. Gelboin and Frank. J. Gonzalez
    Drug Metabolism and Disposition July 2003, 31 (7) 924-931; DOI: https://doi.org/10.1124/dmd.31.7.924
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    METABOLISM-BASED INACTIVATION OF NEURONAL NITRIC-OXIDE SYNTHASE BY COMPONENTS OF CIGARETTE AND CIGARETTE SMOKE
    Damon R. Demady, Ezra R. Lowe, Andrew C. Everett, Scott S. Billecke, Yasuhiko Kamada, Anwar Y. Dunbar and Yoichi Osawa
    Drug Metabolism and Disposition July 2003, 31 (7) 932-937; DOI: https://doi.org/10.1124/dmd.31.7.932
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    IN VITRO METABOLISM OF MIDAZOLAM, TRIAZOLAM, NIFEDIPINE, AND TESTOSTERONE BY HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROMES P450: ROLE OF CYP3A4 AND CYP3A5
    Kiran C. Patki, Lisa L. von Moltke and David J. Greenblatt
    Drug Metabolism and Disposition July 2003, 31 (7) 938-944; DOI: https://doi.org/10.1124/dmd.31.7.938
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    PREDICTION OF THE IN VIVO INTERACTION BETWEEN MIDAZOLAM AND MACROLIDES BASED ON IN VITRO STUDIES USING HUMAN LIVER MICROSOMES
    Kiyomi Ito, Kanako Ogihara, Shin-ichi Kanamitsu and Tomoo Itoh
    Drug Metabolism and Disposition July 2003, 31 (7) 945-954; DOI: https://doi.org/10.1124/dmd.31.7.945
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    CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION
    Richard Weaver, Ken S. Graham, Iain G. Beattie and Rob J. Riley
    Drug Metabolism and Disposition July 2003, 31 (7) 955-966; DOI: https://doi.org/10.1124/dmd.31.7.955

Accelerated Communication

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    A NEW CLASS OF CYP2C9 INHIBITORS: PROBING 2C9 SPECIFICITY WITH HIGH-AFFINITY BENZBROMARONE DERIVATIVES
    Charles W. Locuson, Jan L. Wahlstrom, Denise A. Rock, Dan A. Rock and Jeffrey P. Jones
    Drug Metabolism and Disposition July 2003, 31 (7) 967-971; DOI: https://doi.org/10.1124/dmd.31.7.967
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Drug Metabolism and Disposition: 31 (7)
Drug Metabolism and Disposition
Vol. 31, Issue 7
1 Jul 2003
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