Table of Contents

Articles

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  PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS

  Donglu Zhang, Marc Ogan, Richard Gedamke, Vikram Roongta, Renke Dai, Mingshe Zhu, J. Kent Rinehart, Lewis Klunk and James Mitroka

  Drug Metabolism and Disposition July 2003, 31 (7) 837-845; DOI: https://doi.org/10.1124/dmd.31.7.837
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  IN VITRO METABOLISM OF THE MAMMALIAN SOLUBLE EPOXIDE HYDROLASE INHIBITOR, 1-CYCLOHEXYL-3-DODECYL-UREA

  Takaho Watanabe, Christophe Morisseau, John W. Newman and Bruce D. Hammock

  Drug Metabolism and Disposition July 2003, 31 (7) 846-853; DOI: https://doi.org/10.1124/dmd.31.7.846
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  TWO NEW POLYMORPHISMS OF THE FMO3 GENE IN CAUCASIAN AND AFRICAN-AMERICAN POPULATIONS: COMPARATIVE GENETIC AND FUNCTIONAL STUDIES

  Virginie Lattard, Jun Zhang, Quyen Tran, Bjarte Furnes, Daniel Schlenk and John R. Cashman

  Drug Metabolism and Disposition July 2003, 31 (7) 854-860; DOI: https://doi.org/10.1124/dmd.31.7.854
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  ELETRIPTAN METABOLISM BY HUMAN HEPATIC CYP450 ENZYMES AND TRANSPORT BY HUMAN P-GLYCOPROTEIN

  David C. Evans, Desmond O'Connor, Brian G. Lake, Raymond Evers, Christopher Allen and Richard Hargreaves

  Drug Metabolism and Disposition July 2003, 31 (7) 861-869; DOI: https://doi.org/10.1124/dmd.31.7.861
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  CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR-α CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS

  Timothy K. Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J. Beaudet, Summer Jolley, Thomas A. Brodie, Robert C. Andrews, J. David Becherer, Darryl L. McDougald, Michael D. Gaul, Debie J. Hoivik, Kathy Mellon-Kusibab, Jurgen Lehmann, Steven Kliewer, Steven Novick, Ron Laethem, Zhiyang Zhao and Edward L. LeCluyse

  Drug Metabolism and Disposition July 2003, 31 (7) 870-877; DOI: https://doi.org/10.1124/dmd.31.7.870
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  IN VITRO METABOLISM OF CLINDAMYCIN IN HUMAN LIVER AND INTESTINAL MICROSOMES

  Michael A. Wynalda, J. Matthew Hutzler, Michael D. Koets, Terry Podoll and Larry C. Wienkers

  Drug Metabolism and Disposition July 2003, 31 (7) 878-887; DOI: https://doi.org/10.1124/dmd.31.7.878
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  VERAPAMIL: METABOLISM IN CULTURES OF PRIMARY HUMAN CORONARY ARTERIAL ENDOTHELIAL CELLS

  Jürgen Borlak, Markus Walles, Karsten Levsen and Thomas Thum

  Drug Metabolism and Disposition July 2003, 31 (7) 888-891; DOI: https://doi.org/10.1124/dmd.31.7.888
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  COMPARATIVE DISPOSITION OF (R)-(+)-PULEGONE IN B6C3F1 MICE AND F344 RATS

  L.-J. Chen, E. H. Lebetkin and L. T. Burka

  Drug Metabolism and Disposition July 2003, 31 (7) 892-899; DOI: https://doi.org/10.1124/dmd.31.7.892
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  DECABROMODIPHENYL ETHER IN THE RAT: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

  Anna Mörck, Heldur Hakk, Ulrika Örn and Eva Klasson Wehler

  Drug Metabolism and Disposition July 2003, 31 (7) 900-907; DOI: https://doi.org/10.1124/dmd.31.7.900
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  NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16α-CARBONITRILE

  Chuan Chen, Jeff L. Staudinger and Curtis D. Klaassen

  Drug Metabolism and Disposition July 2003, 31 (7) 908-915; DOI: https://doi.org/10.1124/dmd.31.7.908
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  KINETIC STUDY ON THE REACTION OF CISPLATIN WITH METALLOTHIONEIN

  Douglas Hagrman, Jerry Goodisman, James C. Dabrowiak and Abdul-Kader Souid

  Drug Metabolism and Disposition July 2003, 31 (7) 916-923; DOI: https://doi.org/10.1124/dmd.31.7.916
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  IDENTIFICATION OF CYP1A2 AS THE MAIN ISOFORM FOR THE PHASE I HYDROXYLATED METABOLISM OF GENISTEIN AND A PRODRUG CONVERTING ENZYME OF METHYLATED ISOFLAVONES

  Ming Hu, Kristopher Krausz, Jun Chen, Xia Ge, Jianqi Li, Harry L. Gelboin and Frank. J. Gonzalez

  Drug Metabolism and Disposition July 2003, 31 (7) 924-931; DOI: https://doi.org/10.1124/dmd.31.7.924
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  METABOLISM-BASED INACTIVATION OF NEURONAL NITRIC-OXIDE SYNTHASE BY COMPONENTS OF CIGARETTE AND CIGARETTE SMOKE

  Damon R. Demady, Ezra R. Lowe, Andrew C. Everett, Scott S. Billecke, Yasuhiko Kamada, Anwar Y. Dunbar and Yoichi Osawa

  Drug Metabolism and Disposition July 2003, 31 (7) 932-937; DOI: https://doi.org/10.1124/dmd.31.7.932
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  IN VITRO METABOLISM OF MIDAZOLAM, TRIAZOLAM, NIFEDIPINE, AND TESTOSTERONE BY HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROMES P450: ROLE OF CYP3A4 AND CYP3A5

  Kiran C. Patki, Lisa L. von Moltke and David J. Greenblatt

  Drug Metabolism and Disposition July 2003, 31 (7) 938-944; DOI: https://doi.org/10.1124/dmd.31.7.938
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  PREDICTION OF THE IN VIVO INTERACTION BETWEEN MIDAZOLAM AND MACROLIDES BASED ON IN VITRO STUDIES USING HUMAN LIVER MICROSOMES

  Kiyomi Ito, Kanako Ogihara, Shin-ichi Kanamitsu and Tomoo Itoh

  Drug Metabolism and Disposition July 2003, 31 (7) 945-954; DOI: https://doi.org/10.1124/dmd.31.7.945
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  CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION

  Richard Weaver, Ken S. Graham, Iain G. Beattie and Rob J. Riley

  Drug Metabolism and Disposition July 2003, 31 (7) 955-966; DOI: https://doi.org/10.1124/dmd.31.7.955