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CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR-α CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS

Timothy K. Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J. Beaudet, Summer Jolley, Thomas A. Brodie, Robert C. Andrews, J. David Becherer, Darryl L. McDougald, Michael D. Gaul, Debie J. Hoivik, Kathy Mellon-Kusibab, Jurgen Lehmann, Steven Kliewer, Steven Novick, Ron Laethem, Zhiyang Zhao and Edward L. LeCluyse
Drug Metabolism and Disposition July 2003, 31 (7) 870-877; DOI: https://doi.org/10.1124/dmd.31.7.870

Article Information

vol. 31 no. 7 870-877
DOI 
https://doi.org/10.1124/dmd.31.7.870
PubMed 
12814963
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 13, 2002
  • Accepted March 24, 2003
  • Published online July 1, 2003.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Timothy K. Tippin,
  2. Geraldine Hamilton,
  3. Linda Moore,
  4. Elizabeth J. Beaudet,
  5. Summer Jolley,
  6. Thomas A. Brodie,
  7. Robert C. Andrews,
  8. J. David Becherer,
  9. Darryl L. McDougald,
  10. Michael D. Gaul,
  11. Debie J. Hoivik,
  12. Kathy Mellon-Kusibab,
  13. Jurgen Lehmann,
  14. Steven Kliewer,
  15. Steven Novick,
  16. Ron Laethem,
  17. Zhiyang Zhao and
  18. Edward L. LeCluyse
  1. GlaxoSmithKline, Research Triangle Park, North Carolina (T.K.T., L.M., E.J.B., T.A.B., R.C.A., J.D.B., D.L.M., M.D.G., D.J.H., K.M.-K., J.L., S.K., S.N., R.L., Z.Z.); and Division of Drug Delivery and Disposition, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina (T.K.T., G.H., S.J., E.L.L.)
  1. Address correspondence to:
    Timothy K. Tippin, Drug Metabolism and Pharmacokinetics Department, Metabolic and Viral Diseases Center of Excellence in Drug Discovery, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709. E-mail Tim.K.Tippin{at}gsk.com
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Research ArticleArticle

CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR-α CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS

Timothy K. Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J. Beaudet, Summer Jolley, Thomas A. Brodie, Robert C. Andrews, J. David Becherer, Darryl L. McDougald, Michael D. Gaul, Debie J. Hoivik, Kathy Mellon-Kusibab, Jurgen Lehmann, Steven Kliewer, Steven Novick, Ron Laethem, Zhiyang Zhao and Edward L. LeCluyse
Drug Metabolism and Disposition July 1, 2003, 31 (7) 870-877; DOI: https://doi.org/10.1124/dmd.31.7.870
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