IN VITRO METABOLISM OF MIDAZOLAM, TRIAZOLAM, NIFEDIPINE, AND TESTOSTERONE BY HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROMES P450: ROLE OF CYP3A4 AND CYP3A5

Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine; and the Division of Clinical Pharmacology, Tufts-New England Medical Center, Boston, Massachusetts

Address correspondence to:
Dr. David J. Greenblatt, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. E-mail: DJ.Greenblatt{at}tufts.edu

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	Abstract	Full	Pdf
Jun 2003	93	106	243
Jul 2003	73	203	239
Aug 2003	34	65	83
Sep 2003	42	83	82
Oct 2003	35	62	64
Nov 2003	30	65	62
Dec 2003	35	95	39
Jan 2004	29	67	49
Feb 2004	17	57	61
Mar 2004	17	71	67
Apr 2004	35	59	42
May 2004	13	45	44
Jun 2004	35	95	83
Jul 2004	25	59	91
Aug 2004	30	77	69
Sep 2004	52	85	63
Oct 2004	30	86	45
Nov 2004	27	105	90
Dec 2004	26	62	42
Jan 2005	37	80	76
Feb 2005	34	116	73
Mar 2005	35	93	74
Apr 2005	14	61	44
May 2005	18	91	59
Jun 2005	24	77	63
Jul 2005	21	57	46
Aug 2005	16	64	59
Sep 2005	20	60	48
Oct 2005	19	62	49
Nov 2005	30	77	63
Dec 2005	11	62	33
Jan 2006	20	60	40
Feb 2006	23	91	46
Mar 2006	17	83	43
Apr 2006	9	60	36
May 2006	20	69	46
Jun 2006	21	72	46
Jul 2006	27	55	35
Aug 2006	41	63	38
Sep 2006	17	53	49
Oct 2006	28	64	50
Nov 2006	31	43	47
Dec 2006	25	40	29
Jan 2007	28	53	53
Feb 2007	29	41	50
Mar 2007	17	46	42
Apr 2007	13	48	32
May 2007	29	43	51
Jun 2007	8	32	34
Jul 2007	19	48	33
Aug 2007	21	40	35
Sep 2007	27	55	50
Oct 2007	25	36	50
Nov 2007	17	51	47
Dec 2007	8	29	35
Jan 2008	14	28	25
Feb 2008	9	27	32
Mar 2008	19	35	36
Apr 2008	11	32	46
May 2008	16	35	33
Jun 2008	9	27	35
Jul 2008	25	30	34
Aug 2008	34	46	36
Sep 2008	38	50	30
Oct 2008	33	30	29
Nov 2008	28	23	32
Dec 2008	25	37	20
Jan 2009	19	30	60
Feb 2009	26	48	60
Mar 2009	40	32	42
Apr 2009	27	30	51
May 2009	29	27	46
Jun 2009	23	36	55
Jul 2009	22	31	37
Aug 2009	25	25	38
Sep 2009	33	28	47
Oct 2009	38	42	44
Nov 2009	40	38	37
Dec 2009	44	37	26
Jan 2010	43	39	31
Feb 2010	41	29	47
Mar 2010	54	43	40
Apr 2010	22	43	23
May 2010	31	33	30
Jun 2010	32	50	40
Jul 2010	50	58	45
Aug 2010	21	42	32
Sep 2010	21	61	47
Oct 2010	25	65	55
Nov 2010	17	75	44
Dec 2010	17	63	31
Jan 2011	18	48	35
Feb 2011	24	69	37
Mar 2011	41	67	65
Apr 2011	37	45	56
May 2011	51	67	84
Jun 2011	56	53	78
Jul 2011	55	37	50
Aug 2011	49	40	51
Sep 2011	57	47	73
Oct 2011	64	31	61
Nov 2011	39	28	42
Dec 2011	23	42	53
Jan 2012	36	35	70
Feb 2012	46	36	65
Mar 2012	56	56	69
Apr 2012	47	49	76
May 2012	54	64	98
Jun 2012	43	70	98
Jul 2012	39	68	75
Aug 2012	25	38	58
Sep 2012	43	50	85
Oct 2012	55	48	63
Nov 2012	32	69	69
Dec 2012	25	53	39
Jan 2013	68	65	54
Feb 2013	72	97	71
Mar 2013	74	85	83
Apr 2013	54	81	61
May 2013	64	78	75
Jun 2013	38	32	43
Jul 2013	36	53	51
Aug 2013	20	34	50
Sep 2013	47	40	51
Oct 2013	64	52	72
Nov 2013	49	37	73
Dec 2013	12	55	46
Jan 2014	62	76	68
Feb 2014	36	49	57
Mar 2014	57	54	86
Apr 2014	59	80	109
May 2014	58	52	72
Jun 2014	29	40	70
Jul 2014	40	38	43
Aug 2014	24	45	43
Sep 2014	32	42	57
Oct 2014	42	49	49
Nov 2014	60	60	72
Dec 2014	35	37	47
Jan 2015	27	41	44
Feb 2015	37	57	58
Mar 2015	45	69	74
Apr 2015	37	62	69
May 2015	32	64	98
Jun 2015	36	47	84
Jul 2015	34	58	62
Aug 2015	24	43	48
Sep 2015	27	50	53
Oct 2015	36	58	61
Nov 2015	22	41	45
Dec 2015	17	48	32
Jan 2016	35	48	65
Feb 2016	27	47	57
Mar 2016	28	39	83
Apr 2016	36	51	101
May 2016	23	37	66
Jun 2016	23	57	100
Jul 2016	41	60	58
Aug 2016	27	46	51
Sep 2016	25	47	63
Oct 2016	30	67	75
Nov 2016	19	78	92
Dec 2016	18	32	37
Jan 2017	20	44	33
Feb 2017	17	55	48
Mar 2017	27	43	35
Apr 2017	19	32	26
May 2017	19	45	65
Jun 2017	12	35	80
Jul 2017	11	22	61
Aug 2017	15	62	58
Sep 2017	9	216	51
Oct 2017	11	150	72
Nov 2017	17	79	55
Dec 2017	18	36	26
Jan 2018	12	43	52
Feb 2018	33	47	46
Mar 2018	16	84	61
Apr 2018	7	47	38
May 2018	14	50	51
Jun 2018	11	66	78
Jul 2018	11	45	64
Aug 2018	17	36	66
Sep 2018	12	40	59
Oct 2018	19	45	83
Nov 2018	19	46	60
Dec 2018	46	10	20
Jan 2019	82	14	21
Feb 2019	98	8	19
Mar 2019	75	14	18
Apr 2019	102	9	17
May 2019	66	11	13
Jun 2019	56	15	23
Jul 2019	43	7	12
Aug 2019	55	8	9
Sep 2019	63	10	9
Oct 2019	73	17	17
Nov 2019	77	9	18
Dec 2019	80	18	10
Jan 2020	70	13	18
Feb 2020	79	21	22
Mar 2020	69	23	24
Apr 2020	67	8	17
May 2020	54	7	7
Jun 2020	47	8	11
Jul 2020	48	5	6
Aug 2020	54	8	12
Sep 2020	53	12	16
Oct 2020	74	14	10
Nov 2020	48	7	5
Dec 2020	75	7	5
Jan 2021	39	41	12
Feb 2021	49	46	18
Mar 2021	72	21	20
Apr 2021	42	16	13
May 2021	95	22	12
Jun 2021	62	24	5
Jul 2021	59	11	12
Aug 2021	61	22	8
Sep 2021	57	17	10
Oct 2021	30	10	11
Nov 2021	53	15	17
Dec 2021	75	9	14
Jan 2022	50	12	10