ISOFORM SELECTIVITY AND KINETICS OF MORPHINE 3- AND 6-GLUCURONIDATION BY HUMAN UDP-GLUCURONOSYLTRANSFERASES: EVIDENCE FOR ATYPICAL GLUCURONIDATION KINETICS BY UGT2B7

Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University, Adelaide, Australia (A.N.S., P.I.M., J.O.M.); and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (A.G., J.B.H.)

Address correspondence to:
Professor John O. Miners, Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. E-mail: john.miners{at}flinders.edu.au

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Article usage: August 2003 to May 2022

	Abstract	Full	Pdf
Aug 2003	55	61	84
Sep 2003	29	52	49
Oct 2003	19	30	36
Nov 2003	23	41	34
Dec 2003	10	24	21
Jan 2004	19	29	20
Feb 2004	18	30	31
Mar 2004	10	23	19
Apr 2004	8	32	21
May 2004	14	21	13
Jun 2004	25	50	17
Jul 2004	17	17	12
Aug 2004	21	42	12
Sep 2004	23	30	32
Oct 2004	24	52	30
Nov 2004	23	27	23
Dec 2004	26	30	36
Jan 2005	20	29	20
Feb 2005	21	45	32
Mar 2005	16	37	28
Apr 2005	5	30	15
May 2005	8	27	17
Jun 2005	7	32	21
Jul 2005	10	23	18
Aug 2005	6	25	18
Sep 2005	5	26	20
Oct 2005	6	27	20
Nov 2005	13	19	15
Dec 2005	6	18	16
Jan 2006	12	30	26
Feb 2006	13	37	18
Mar 2006	8	25	10
Apr 2006	1	28	16
May 2006	7	19	9
Jun 2006	10	15	10
Jul 2006	5	18	11
Aug 2006	6	17	12
Sep 2006	8	25	18
Oct 2006	17	32	27
Nov 2006	11	23	16
Dec 2006	5	25	15
Jan 2007	6	13	10
Feb 2007	8	30	14
Mar 2007	8	18	17
Apr 2007	8	25	12
May 2007	8	33	25
Jun 2007	12	25	25
Jul 2007	9	21	14
Aug 2007	6	22	15
Sep 2007	11	29	13
Oct 2007	8	44	24
Nov 2007	10	18	17
Dec 2007	10	15	6
Jan 2008	3	6	9
Feb 2008	13	23	19
Mar 2008	7	10	8
Apr 2008	6	17	26
May 2008	8	11	16
Jun 2008	7	16	17
Jul 2008	16	30	16
Aug 2008	14	16	14
Sep 2008	19	22	13
Oct 2008	16	18	14
Nov 2008	14	8	9
Dec 2008	8	8	9
Jan 2009	2	14	20
Feb 2009	15	17	13
Mar 2009	20	24	24
Apr 2009	7	15	14
May 2009	4	13	15
Jun 2009	11	15	14
Jul 2009	11	10	13
Aug 2009	7	13	8
Sep 2009	14	10	18
Oct 2009	23	22	29
Nov 2009	15	16	18
Dec 2009	24	15	17
Jan 2010	17	10	11
Feb 2010	8	10	10
Mar 2010	15	9	10
Apr 2010	15	12	12
May 2010	19	25	17
Jun 2010	40	17	13
Jul 2010	12	10	9
Aug 2010	11	12	10
Sep 2010	10	16	10
Oct 2010	10	12	9
Nov 2010	22	16	10
Dec 2010	14	19	10
Jan 2011	28	23	13
Feb 2011	17	22	21
Mar 2011	17	22	14
Apr 2011	10	24	24
May 2011	10	19	17
Jun 2011	20	9	12
Jul 2011	17	14	19
Aug 2011	14	26	23
Sep 2011	14	14	18
Oct 2011	16	17	34
Nov 2011	13	22	13
Dec 2011	6	36	18
Jan 2012	12	19	13
Feb 2012	18	18	15
Mar 2012	10	20	14
Apr 2012	13	28	13
May 2012	19	14	11
Jun 2012	14	20	15
Jul 2012	16	30	18
Aug 2012	14	17	11
Sep 2012	27	27	16
Oct 2012	19	15	12
Nov 2012	17	22	28
Dec 2012	18	16	9
Jan 2013	23	19	17
Feb 2013	37	16	11
Mar 2013	31	22	14
Apr 2013	42	35	19
May 2013	29	23	27
Jun 2013	13	13	9
Jul 2013	7	16	9
Aug 2013	9	11	10
Sep 2013	15	20	9
Oct 2013	12	9	9
Nov 2013	5	7	8
Dec 2013	15	10	9
Jan 2014	8	13	8
Feb 2014	9	19	10
Mar 2014	7	8	9
Apr 2014	32	14	20
May 2014	10	13	13
Jun 2014	5	9	11
Jul 2014	17	23	8
Aug 2014	6	13	4
Sep 2014	11	20	20
Oct 2014	17	13	10
Nov 2014	11	9	6
Dec 2014	34	12	17
Jan 2015	19	12	10
Feb 2015	3	10	3
Mar 2015	17	15	16
Apr 2015	24	10	12
May 2015	17	19	9
Jun 2015	17	8	6
Jul 2015	14	9	8
Aug 2015	16	9	5
Sep 2015	16	6	5
Oct 2015	7	2	3
Nov 2015	10	10	8
Dec 2015	11	15	6
Jan 2016	15	3	7
Feb 2016	6	3	2
Mar 2016	12	6	21
Apr 2016	21	12	12
May 2016	7	14	30
Jun 2016	10	9	11
Jul 2016	14	7	6
Aug 2016	12	7	14
Sep 2016	10	13	9
Oct 2016	5	34	6
Nov 2016	3	23	8
Dec 2016	2	16	4
Jan 2017	1	27	5
Feb 2017	3	24	9
Mar 2017	4	15	4
Apr 2017	2	21	3
May 2017	4	24	13
Jun 2017	6	16	6
Jul 2017	1	18	12
Aug 2017	5	23	8
Sep 2017	2	56	8
Oct 2017	5	69	15
Nov 2017	1	66	22
Dec 2017	2	33	8
Jan 2018	5	14	4
Feb 2018	10	36	14
Mar 2018	2	28	10
Apr 2018	9	33	17
May 2018	7	40	11
Jun 2018	1	42	10
Jul 2018	1	15	5
Aug 2018	1	30	10
Sep 2018	1	23	11
Oct 2018	1	44	7
Nov 2018	1	59	6
Dec 2018	60	16	4
Jan 2019	28	7	2
Feb 2019	26	1	1
Mar 2019	31	7	3
Apr 2019	25	10	2
May 2019	24	7	5
Jun 2019	14	13	10
Jul 2019	19	4	1
Aug 2019	40	4	2
Sep 2019	31	1	3
Oct 2019	15	8	5
Nov 2019	16	2	4
Dec 2019	32	17	5
Jan 2020	27	5	2
Feb 2020	11	5	1
Mar 2020	15	7	2
Apr 2020	73	8	7
May 2020	11	4	5
Jun 2020	16	2	3
Jul 2020	22	2	2
Aug 2020	6	3	6
Sep 2020	19	6	4
Oct 2020	21	23	3
Nov 2020	44	3	4
Dec 2020	32	10	2
Jan 2021	29	32	3
Feb 2021	8	37	2
Mar 2021	17	11	2
Apr 2021	26	6	1
May 2021	28	11	2
Jun 2021	11	24	3
Jul 2021	9	10	0
Aug 2021	31	32	7
Sep 2021	19	9	2
Oct 2021	27	10	3
Nov 2021	23	1	0
Dec 2021	34	9	1
Jan 2022	9	5	3
Feb 2022	14	3	1
Mar 2022	39	4	4
Apr 2022	12	4	1
May 2022	7	1	0