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Drug Metabolism & Disposition

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Table of Contents

January 01, 2004; Volume 32,Issue 1

MINIREVIEWS

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    JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY
    Todd D. Porter
    Drug Metabolism and Disposition January 2004, 32 (1) 1-6; DOI: https://doi.org/10.1124/dmd.32.1.1

Short Communication

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    CATALYTIC ROLES OF CYP2C9 AND ITS VARIANTS (CYP2C9*2 AND CYP2C9*3) IN LORNOXICAM 5′-HYDROXYLATION
    Izumi Iida, Atsunori Miyata, Masayuki Arai, Mitsuyo Hirota, Masayuki Akimoto, Shohei Higuchi, Kaoru Kobayashi and Kan Chiba
    Drug Metabolism and Disposition January 2004, 32 (1) 7-9; DOI: https://doi.org/10.1124/dmd.32.1.7

Articles

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    NEW SECONDARY METABOLITES OF PHENYLBUTYRATE IN HUMANS AND RATS
    Takhar Kasumov, Laura L. Brunengraber, Blandine Comte, Michelle A. Puchowicz, Kathryn Jobbins, Katherine Thomas, France David, Renee Kinman, Suzanne Wehrli, William Dahms, Douglas Kerr, Itzhak Nissim and Henri Brunengraber
    Drug Metabolism and Disposition January 2004, 32 (1) 10-19; DOI: https://doi.org/10.1124/dmd.32.1.10
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    SUPPRESSION OF DRUG-METABOLIZING ENZYMES AND EFFLUX TRANSPORTERS IN THE INTESTINE OF ENDOTOXIN-TREATED RATS
    J. Kalitsky-Szirtes, A. Shayeganpour, D.R. Brocks and M. Piquette-Miller
    Drug Metabolism and Disposition January 2004, 32 (1) 20-27; DOI: https://doi.org/10.1124/dmd.32.1.20
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    IN VITRO METABOLISM OF HYPERFORIN IN RAT LIVER MICROSOMAL SYSTEMS
    Yanyan Cui, Catharina Y.W. Ang, Richard D. Beger, Thomas M. Heinze, Lihong Hu and Julian Leakey
    Drug Metabolism and Disposition January 2004, 32 (1) 28-34; DOI: https://doi.org/10.1124/dmd.32.1.28
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    THE PREGNANE X RECEPTOR BINDS TO RESPONSE ELEMENTS IN A GENOMIC CONTEXT-DEPENDENT MANNER, AND PXR ACTIVATOR RIFAMPICIN SELECTIVELY ALTERS THE BINDING AMONG TARGET GENES
    Xiulong Song, Mingxing Xie, He Zhang, Yuxin Li, Karuna Sachdeva and Bingfang Yan
    Drug Metabolism and Disposition January 2004, 32 (1) 35-42; DOI: https://doi.org/10.1124/dmd.32.1.35
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    N-ACETYLATION OF THE GLUTAMATE RESIDUE OF INTACT GLUTATHIONE CONJUGATES IN RATS: A NOVEL PATHWAY FOR THE METABOLIC PROCESSING OF THIOL ADDUCTS OF XENOBIOTICS
    Wenji Yin, George A. Doss, Ralph A. Stearns and Sanjeev Kumar
    Drug Metabolism and Disposition January 2004, 32 (1) 43-48; DOI: https://doi.org/10.1124/dmd.32.1.43
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    CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES
    Deepak K. Dalvie and Thomas N. O'Connell
    Drug Metabolism and Disposition January 2004, 32 (1) 49-57; DOI: https://doi.org/10.1124/dmd.32.1.49
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    METABOLISM OF APIGENIN BY RAT LIVER PHASE I AND PHASE II ENZYMES AND BY ISOLATED PERFUSED RAT LIVER
    Angéline Gradolatto, Marie-Chantal Canivenc-Lavier, Jean-Philippe Basly, Marie-Hélène Siess and Caroline Teyssier
    Drug Metabolism and Disposition January 2004, 32 (1) 58-65; DOI: https://doi.org/10.1124/dmd.32.1.58
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    CYP3A INDUCTION BY LIVER X RECEPTOR LIGANDS IN PRIMARY CULTURED RAT AND MOUSE HEPATOCYTES IS MEDIATED BY THE PREGNANE X RECEPTOR
    Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Alipour, Mary D. Gargano, Melissa Runge-Morris and Thomas A. Kocarek
    Drug Metabolism and Disposition January 2004, 32 (1) 66-71; DOI: https://doi.org/10.1124/dmd.32.1.66
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    CHARACTERIZATION OF N-GLUCURONIDATION OF THE LUNG CARCINOGEN 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANOL (NNAL) IN HUMAN LIVER: IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A4
    Doris Wiener, Daniel R. Doerge, Jia-Long Fang, Pramod Upadhyaya and Philip Lazarus
    Drug Metabolism and Disposition January 2004, 32 (1) 72-79; DOI: https://doi.org/10.1124/dmd.32.1.72
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    THE OLIVACINE DERIVATIVE S 16020 (9-HYDROXY-5,6-DIMETHYL-N-[2-(DIMETHYLAMINO)ETHYL)-6H-PYRIDO(4,3-B)-CARBAZOLE-1-CARBOXAMIDE) INDUCES CYP1A AND ITS OWN METABOLISM IN HUMAN HEPATOCYTES IN PRIMARY CULTURE
    Lydiane Pichard-Garcia, Richard John Weaver, Nina Eckett, Graeme Scarfe, Jean-Michel Fabre, Catherine Lucas and Patrick Maurel
    Drug Metabolism and Disposition January 2004, 32 (1) 80-88; DOI: https://doi.org/10.1124/dmd.32.1.80
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    POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE
    R. Scott Obach
    Drug Metabolism and Disposition January 2004, 32 (1) 89-97; DOI: https://doi.org/10.1124/dmd.32.1.89
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    METABOLISM OF OPIOIDS IS ALTERED IN LIVER MICROSOMES OF SICKLE CELL TRANSGENIC MICE
    Swati Nagar, Rory P. Remmel, Robert P. Hebbel and Cheryl L. Zimmerman
    Drug Metabolism and Disposition January 2004, 32 (1) 98-104; DOI: https://doi.org/10.1124/dmd.32.1.98
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    HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE
    David M. Stresser, Marc I. Broudy, Thuy Ho, Catherine E. Cargill, Andrew P. Blanchard, Raman Sharma, Andre A. Dandeneau, Joseph J. Goodwin, Stephanie D. Turner, John C. L. Erve, Christopher J. Patten, Shangara S. Dehal and Charles L. Crespi
    Drug Metabolism and Disposition January 2004, 32 (1) 105-112; DOI: https://doi.org/10.1124/dmd.32.1.105
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    STUDIES ON THE METABOLISM OF THE NOVEL, SELECTIVE CYCLOOXYGENASE-2 INHIBITOR INDOMETHACIN PHENETHYLAMIDE IN RAT, MOUSE, AND HUMAN LIVER MICROSOMES: IDENTIFICATION OF ACTIVE METABOLITES
    Rory P. Remmel, Brenda C. Crews, Kevin R. Kozak, Amit S. Kalgutkar and Lawrence J. Marnett
    Drug Metabolism and Disposition January 2004, 32 (1) 113-122; DOI: https://doi.org/10.1124/dmd.32.1.113
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    METABOLISM AND MUTAGENICITY OF SOURCE WATER CONTAMINANTS 1,3-DICHLOROPROPANE AND 2,2-DICHLOROPROPANE
    Rogelio Tornero-Velez, Matthew K. Ross, Courtney Granville, John Laskey, Jeffrey P. Jones, David M. DeMarini and Marina V. Evans
    Drug Metabolism and Disposition January 2004, 32 (1) 123-131; DOI: https://doi.org/10.1124/dmd.32.1.123
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    DEVELOPMENT OF A COMPUTATIONAL APPROACH TO PREDICT BLOOD-BRAIN BARRIER PERMEABILITY
    Xingrong Liu, Meihua Tu, Rebecca S. Kelly, Cuiping Chen and Bill J. Smith
    Drug Metabolism and Disposition January 2004, 32 (1) 132-139; DOI: https://doi.org/10.1124/dmd.32.1.132
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    AN ASSESSMENT OF UDP-GLUCURONOSYLTRANSFERASE INDUCTION USING PRIMARY HUMAN HEPATOCYTES
    Matthew G. Soars, David M. Petullo, James A. Eckstein, Steve C. Kasper and Steven A. Wrighton
    Drug Metabolism and Disposition January 2004, 32 (1) 140-148; DOI: https://doi.org/10.1124/dmd.32.1.140
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    FUNCTIONAL CHARACTERIZATION OF FOUR NATURALLY OCCURRING VARIANTS OF HUMAN PREGNANE X RECEPTOR (PXR): ONE VARIANT CAUSES DRAMATIC LOSS OF BOTH DNA BINDING ACTIVITY AND THE TRANSACTIVATION OF THE CYP3A4 PROMOTER/ENHANCER REGION
    Satoru Koyano, Kouichi Kurose, Yoshiro Saito, Shogo Ozawa, Ryuichi Hasegawa, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Toshiharu Nakajima, Kenji Matsumoto, Akira Akasawa, Hirohisa Saito and Jun-Ichi Sawada
    Drug Metabolism and Disposition January 2004, 32 (1) 149-154; DOI: https://doi.org/10.1124/dmd.32.1.149
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    TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B5 AND OF SITE-DIRECTED MUTAGENESIS
    Yoshitaka Yamaguchi, Kishore K. Khan, You Ai He, You Qun He and James R. Halpert
    Drug Metabolism and Disposition January 2004, 32 (1) 155-161; DOI: https://doi.org/10.1124/dmd.32.1.155
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Drug Metabolism and Disposition: 32 (1)
Drug Metabolism and Disposition
Vol. 32, Issue 1
1 Jan 2004
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  • MINIREVIEWS
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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