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Cover Caption

Molecular model of the CYP3A4 active site showing amino acid residues studied. See the article by Yamaguchi et al. on page 155 of this issue.

In this issue

Drug Metabolism and Disposition: 32 (1)

Drug Metabolism and Disposition

Vol. 32, Issue 1

1 Jan 2004

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

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