Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
OtherMINIREVIEWS

JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY

Todd D. Porter
Drug Metabolism and Disposition January 2004, 32 (1) 1-6; DOI: https://doi.org/10.1124/dmd.32.1.1
Todd D. Porter
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The year 2004 marks the 50th anniversary of the discovery of cytochrome P450. Minor J. (Jud) Coon has been a leader in this field for the last 35 years. This review summarizes his contributions to P450 research by discussing six of his most significant publications; not surprisingly, these papers serve as landmarks for the major directions followed in P450 research.

Footnotes

  • ↵1 Martin Klingenberg (Klingenberg, 2003) notes that his initial observation of a P450-CO spectrum was made in November 1954 but was not published until 1958. David Garfinkel joined the laboratory in 1955.

  • ↵2 Ron Estabrook published a similar version of the catalytic cycle in the same issue of this journal (Estabrook et al., 1973) and an earlier, less elaborate version in 1971 (Estabrook et al., 1971).

  • ↵3 Several reviews on the early history of P450 have recently appeared; in addition to those cited here (Lu, 1998; Coon, 2002; Klingenberg, 2003), personal accounts by Gil Mannering (Mannering, 2001) and Allan Conney (Conney, 2003), and an early account by David Cooper (Cooper, 1973) are also of interest.

  • Supported by National Science Foundation Grant MCB-9808636. A lecture and poster of this review were presented at the session honoring Minor J. Coon at the “12th International Conference on Cytochrome P450: Biochemistry, Biophysics and Molecular Biology” in La Grande Motte, France, in September 2001.

  • Todd D. Porter received a B.S. in Biochemistry from the University of Illinois in 1976 and his Ph.D. in Pharmacology from the same institution in 1981. His graduate work was with Martin Schulman on the induction of drug-metabolizing enzymes by ethanol feeding. He carried out postdoctoral research with Charles Kasper at the University of Wisconsin, working on cytochrome P450 reductase, and was an Assistant Professor under Jud Coon at Michigan from 1986 to 1991, where they pioneered the use of bacteria for the expression of cytochrome P450. He has continued his research in this area, publishing a number of articles on the use of bacteria for biotechnological and enzymological investigations of cytochrome P450 and cytochrome P450 reductase.
    Embedded Image

  • Dr. Porter is an Associate Professor in the College of Pharmacy at the University of Kentucky and also serves as the Director of Graduate Studies for the Graduate Center for Toxicology under Dr. Mary Vore. He is on the Editorial Board of the Journal of Biochemical and Molecular Toxicology.

    • Received August 14, 2003.
    • Accepted September 2, 2003.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

 

DMD articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 32 (1)
Drug Metabolism and Disposition
Vol. 32, Issue 1
1 Jan 2004
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
OtherMINIREVIEWS

JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY

Todd D. Porter
Drug Metabolism and Disposition January 1, 2004, 32 (1) 1-6; DOI: https://doi.org/10.1124/dmd.32.1.1

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
OtherMINIREVIEWS

JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY

Todd D. Porter
Drug Metabolism and Disposition January 1, 2004, 32 (1) 1-6; DOI: https://doi.org/10.1124/dmd.32.1.1
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • 1. Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes
    • 2. Purified Liver Microsomal Cytochrome P-450: Separation and Characterization of Multiple Forms
    • 3. Purified Liver Microsomal NADPH-Cytochrome P-450 Reductase: Spectral Characterization of Oxidation States
    • 4. Purification and Characterization of a Unique Isozyme of Cytochrome P-450 from Liver Microsomes of Ethanol-Treated Rabbits
    • 5. Alcohol-Inducible Cytochrome P-450IIE1 Lacking the Hydrophobic NH2-terminal Segment Retains Catalytic Activity and Is Membrane-Bound When Expressed in Escherichia coli
    • 6. Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • A Decade in the MIST
  • A Review of PK-Based DDIs in 2013–2016 NDAs
  • A review of drug disposition and DDIs in 2015 NDAs
Show more Minireviews

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics