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Research ArticleArticle

TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B5 AND OF SITE-DIRECTED MUTAGENESIS

Yoshitaka Yamaguchi, Kishore K. Khan, You Ai He, You Qun He and James R. Halpert
Drug Metabolism and Disposition January 2004, 32 (1) 155-161; DOI: https://doi.org/10.1124/dmd.32.1.155

Article Information

vol. 32 no. 1 155-161
DOI 
https://doi.org/10.1124/dmd.32.1.155
PubMed 
14709633
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 30, 2003
  • Accepted September 22, 2003
  • Published online January 6, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshitaka Yamaguchi,
  2. Kishore K. Khan1,
  3. You Ai He,
  4. You Qun He and
  5. James R. Halpert
  1. Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas
  1. Address correspondence to:
    Dr. Yoshitaka Yamaguchi, Department of Drug Metabolism and Pharmacokinetics, Development Research Laboratories, Shionogi & Co., LTD., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan. E-mail: yoshitaka.yamaguchi{at}shionogi.co.jp
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Research ArticleArticle

TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B5 AND OF SITE-DIRECTED MUTAGENESIS

Yoshitaka Yamaguchi, Kishore K. Khan, You Ai He, You Qun He and James R. Halpert
Drug Metabolism and Disposition January 1, 2004, 32 (1) 155-161; DOI: https://doi.org/10.1124/dmd.32.1.155
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